RESUMEN
Five new triterpenoid saponins, nipponosides A-E (1, 3-6), were isolated from Acanthopanax nipponicus leaves, along with a known saponin, kalopanaxsaponin G (2). Nipponosides A-E were characterized as the 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta -D-glucopyranosyl ester of 3-oxohederagenin, oleanolic acid 3-O-beta-D-glucopyranoside, gypsogenin 3-O-beta-D-glucopyranoside, 3beta,23,29-trihydroxyolean-12-en-28-oic acid, and 3beta,20alpha, 23-trihydroxy-30-nor-olean-12-en-28-oic acid, respectively. The structures of these new compounds were based on chemical and spectral methods.
Asunto(s)
Plantas Medicinales/química , Saponinas/química , Triterpenos/química , Secuencia de Carbohidratos , Espectroscopía de Resonancia Magnética , Datos de Secuencia Molecular , Hojas de la Planta/química , Saponinas/aislamiento & purificación , Espectrometría de Masa Bombardeada por Átomos Veloces , Triterpenos/aislamiento & purificaciónRESUMEN
Two new saponins (cirensenoside Q and R) were isolated from the leaves of Oplopanax elatus. Their structures were elucidated as follows: Q, gypsogenin 3-O-beta-glucopyranosyl-28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D- glucopyranosyl(1-->6)-beta-D-glucopyranoside; R, 3 beta-hydroxylup-20(29)-ene-23-al-28-oic acid 3-O-beta-D-glucopyranosyl-28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D- glucopyranosyl(1-->6)-beta-D-glucopyranoside, respectively.
Asunto(s)
Ácido Oleanólico/análogos & derivados , Plantas Medicinales/química , Saponinas/aislamiento & purificación , Triterpenos , Magnoliopsida/química , Estructura Molecular , Hojas de la Planta/química , Saponinas/químicaRESUMEN
In a continuation of phytochemical studies on the underground organs of Liriope spicata var. prolifera, four new steroidal glycosides, lirioproliosides A-D, along with two known compounds, 25(S)-ruscogenin 1-O-[alpha-L-rhamnopyranosyl(1-->2)[beta-D-xylopyranosyl (1-->3)]-beta-D-fucopyranoside and ophiopogonin A, were identified. The structures of lirioproliosides A-D were established by a combination of spectroscopic and chemical methods as 25(S)-ruscogenin 1-O-[alpha-L-rhamnopyranosyl(1-->2)][beta-D-xylopyranosyl (1-->3)]-beta-D-fucopyranoside-3-O-alpha-L-rhamnopyranoside, 25(S)-ruscogenin 1-O-[3-O-acetyl-alpha-L-rhamnopyranosyl(1-->2)]-beta-D-fucopyranoside, 25(S)-ruscogenin (1-O-[2-O-acetyl-alpha-L-rhamnopyranosyl (1-->2)]-beta-D-fucopyranoside and ruscogenin (1-O-[2-O-acetyl-alpha-L-rhamnopyranosyl(1-->2)]-beta-D-fucopyranoside, respectively. Among these steroidal glycosides, ophiopogonin A and lirioprolioside B, and lirioproliosides C and D, were isolated as epimeric pairs.
Asunto(s)
Glicósidos/aislamiento & purificación , Raíces de Plantas/química , Plantas Medicinales/química , Glicósidos/química , Espectroscopía de Resonancia Magnética , Metilación , Espectrometría de Masa Bombardeada por Átomos VelocesRESUMEN
Two new triterpenoid saponins were isolated from the leaves of Oplopanax elatus Nakai. By measuring physical and chemical constants and spectral data, their structures were elucidated as 3-epi-oleanolic acid 28-O-alpha-L-rhamnopyranosyl (1-->4)-beta-D- glucopyranosyl (1-->6)-beta-D-glucopyranoside; 3-O-beta-D-glucopyranosyl betulinic acid 28-O-beta-D-glucopyranosyl (1-->6)-beta-D-glucopyranoside and named as cirensenosides O and P, respectively.
Asunto(s)
Plantas Medicinales/química , Saponinas , Triterpenos/aislamiento & purificación , Magnoliopsida/química , Estructura Molecular , Hojas de la Planta/química , Triterpenos/químicaRESUMEN
Three new oleanolic acid glycosides, tarasaponins I-III, were isolated as their methyl esters from the root bark of Aralia elata together with four known glycosides, the methyl esters of chikusetsusaponins IVa, IV, 28-desglucosyl-chikusetsusaponin IV and pseudoginsenoside RT1. Tarasaponins I-III were characterized as oleanolic acid 3-O-[beta-D-glucopyranosyl(1-->3)][alpha-L-arabinofuranosyl(1-->4)[- beta-D-glucuronopyranoside, oleanolic acid 3-O-[beta-D-xylopyranosyl(1-->2)][beta-D-galactopyranosyl(1-->3)]-beta- D-glucuronopyranoside and beta-D-glucopyranosyl oleanolate 3-O-beta-D-galactopyranosyl(1-->3)-beta-D-glucuronopyranoside, respectively.
Asunto(s)
Ácido Oleanólico/aislamiento & purificación , Plantas Medicinales/química , Saponinas/aislamiento & purificación , Secuencia de Carbohidratos , Japón , Espectroscopía de Resonancia Magnética , Datos de Secuencia Molecular , Ácido Oleanólico/química , Saponinas/químicaRESUMEN
Two new triterpenoid saponins named sieboldianoside A and B were isolated from the leaves of Acanthopanax sieboldianus together with five known triterpenoid saponins, kalopanax-saponins A and B, saponin A, CP3, sapindoside B, and a known flavonol glycoside, kaempferol 3-O-rutinoside. On the basis of chemical and spectral evidence, the structures of the new saponins (sieboldianoside A and B) were concluded to be alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)- beta-D-glucopyranosyl esters of hederagenin and oleanolic acid 3-O-beta-D- xylopyranosyl(1-->3)-alpha-L-rhamnopyranosyl(1-->2)-alpha-L-arabinopy ranosides, respectively.
Asunto(s)
Medicamentos Herbarios Chinos/química , Ácido Oleanólico/análogos & derivados , Saponinas/aislamiento & purificación , Triterpenos/aislamiento & purificación , Secuencia de Carbohidratos , Espectroscopía de Resonancia Magnética , Datos de Secuencia Molecular , Estructura Molecular , Ácido Oleanólico/química , Ácido Oleanólico/aislamiento & purificación , Saponinas/química , Triterpenos/químicaRESUMEN
Six new triterpenoid glycosides called julibrosides A1-A4, B1 and C1 were isolated from Albizziae Cortex, the dried stem bark of Albizzia julibrissin Durazz. Their structures were determined based on spectral and chemical evidence. Julibrosides B1 and C1 had new sapogenols, designated julibrogenin B and C, respectively, while julibrosides A3 included N-acetyl-D-glucosamine as a sugar component.
Asunto(s)
Medicamentos Herbarios Chinos/química , Glicósidos/química , Plantas Medicinales/química , Sapogeninas/química , Secuencia de Carbohidratos , Medicamentos Herbarios Chinos/aislamiento & purificación , Glicósidos/aislamiento & purificación , Datos de Secuencia Molecular , Extractos Vegetales/química , Sapogeninas/aislamiento & purificaciónRESUMEN
A new phenazine antibiotic, DOB-41, was isolated from the culture broth of a Pseudomonas strain. The antibiotic obtained as yellow crystals showed UV maxima at 255 nm and 370 nm. A molecular formula, C19H18N2O6, was indicated by elemental analysis and mass spectrometry. The structure was elucidated by X-ray diffraction analysis. The antibiotic exhibited inhibitory activity against Gram-positive bacteria, and antitumor effect against leukemia P388 in mice.
Asunto(s)
Antibacterianos/aislamiento & purificación , Antibióticos Antineoplásicos/aislamiento & purificación , Animales , Antibacterianos/uso terapéutico , Antibióticos Antineoplásicos/uso terapéutico , Evaluación Preclínica de Medicamentos , Bacterias Grampositivas/efectos de los fármacos , Leucemia P388/tratamiento farmacológico , Ratones , Fenazinas/aislamiento & purificación , Fenazinas/farmacología , Fenazinas/uso terapéutico , Pseudomonas/análisis , Pseudomonas/clasificación , Análisis Espectral , Difracción de Rayos XAsunto(s)
Antineoplásicos Fitogénicos/análisis , Glicósidos/análisis , Plantas Medicinales/análisis , Pregnenos/análisis , Animales , Antineoplásicos Fitogénicos/farmacología , Fenómenos Químicos , Química , Glicósidos/farmacología , Masculino , Ratones , Ratones Endogámicos ICR , Pregnenos/farmacología , Sarcoma 180/tratamiento farmacológicoRESUMEN
The antihepatotoxic effects of ginsenosides, saponins from PANAX GINSENG, and their aglycones were investigated utilizing carbon tetrachloride (CCl (4))- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes. Prominent protective actions were found with 20( S)-ginsenoside-Rh (2), 20( R)-ginsenoside-Rg (3) and prosapogenin of ginsenoside-Ro, 20( R)- and 20( S)-ginsenoside-Rs in CCl (4)-produced cytotoxicity, and 20( S)-ginsenoside-Rh (1) and prosapogenin of 20( S)-ginsenoside-Rs were effective in preventing GalN-induced liver cell damage. The antihepatotoxic effects of chikusetsusaponins, saponins of PANAX JAPONICUS, were also examined. The structure-activity relationship is discussed.