Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program.

AIMS: The aim of the present study was to evaluate the oral resveratrol effects associated with diet and physical training changes on anthropometric and biochemical parameters. MAIN METHODS: 25 individuals aged from 30 to 60 years old; with Body Mass Index (BMI) ≥ 30 kg/m2 were included in the study. Following the primary evaluation (anthropometric and clinical), the patients were randomly divided into 2 groups: (1) Placebo: Physical activity program + Diet + Placebo; (2) Resveratrol: Physical activity program + Diet + Resveratrol (RVS) (250 mg/day) for three months. Anthropometric and biochemical parameters were evaluated at baseline and after the treatment period. KEY FINDINGS: The main findings showed that the resveratrol supplementation improved total cholesterol (TC), High-density Lipoprotein cholesterol (HDL-c), Very-low density Lipoprotein cholesterol (VLDL-c), urea, creatinine and albumin serum levels. SIGNIFICANCE: These findings indicate that this polyphenol may be an option to potentiate the beneficial effects induced by dietary and physical activity programs in the Metabolic Syndrome (MetS) treatment.

Metabólitos sanguíneos de vacas de corte suplementadas ou não com sais de cálcio de ácidos graxos durante o período pré e/ou pós-parto / Blood metabolites from beef cows supplemented or not with calcium salts of fatty acids during pre and/or postpartum period

Avaliou-se a concentração de metabólitos sanguíneos de vacas de corte mantidas em pastagem natural recebendo suplementação com sais de cálcio de ácidos graxos (SCAG) durante 45 dias antes do parto (PRE), suplementação com SCAG durante 45 dias antes do parto e 63 dias pós-parto (PREPOS), suplementação com SCAG durante 63 dias pós-parto (POS) e de vacas não suplementadas (PN). As coletas de sangue foram realizadas em média 64 dias antes do parto, e aos 21, 42 e 63 dias pós-parto. Não ocorreu interação significativa entre tratamentos e períodos. As concentrações plasmáticas de β-hidroxibutirato (βHB), triglicerídeos (TRIG), colesterol, glicose e ureia não foram afetadas significativamente pela suplementação de gordura protegida. A análise de regressão mostrou queda linear significativa da concentração de TRIG no sangue com o aumento da produção de leite (PL) para as vacas do tratamento PN (TRIG = 23,10 - 2,18*PL, R² = 0,31) e efeito quadrático para as vacas do PRE (TRIG = 6,54 - 1,75*PL + 0,30*PL², R² = 0,62). Nos animais dos tratamentos POS e PREPOS, não houve efeito da produção de leite sobre a concentração de TRIG, indicando que a suplementação durante o período de produção de leite auxilia na manutenção de um balanço energético positivo. As concentrações de colesterol plasmático aumentaram, e as de triglicerídeos e ureia diminuíram linearmente até o final do experimento.

The study evaluated the blood metabolites of beef cows maintained on native pasture supplemented with calcium salts of fatty acids (CSFA) during 45 days pre-partum (PRE); supplemented with CSFA during 45 days pre-partum and 63 days post-partum (PREPOS); supplemented with CSFA during 63 days post-partum (POS) and cows not supplemented (PN): without supplementation. Blood samples were taken 64 days pre-partum, and at 21, 42 and 63 days post-partum. No significant interaction was observed between treatment and period. Plasma concentrations of β-hydroxybutyrate (βHB), triglycerides, cholesterol, glucose and urea were not affected by protected fat supplementation. The regression analysis showed significant linear decline of blood triglycerides (TRIG) concentration with the increase of milk production (PL) for PN cows (TRIG= 23.10 - 2.18*PL, R²= 0.31) and quadratic effect for PRE cows (TRIG= 6.54 - 1.75*PL + 0.30*PL², R²= 0.62). For cows submitted to the POS and PREPOS treatments there was no effect of milk production on blood triglycerides concentration, indicating that CSFA during milk production aids the maintenance of a positive energetic balance. The concentration of plasma cholesterol increased while the concentrations of triglycerides and urea decreased linearly until the end of the experiment.