RESUMEN
<b>Background and Objective:</b> Increased glucose levels in diabetes mellitus patients affect angiogenesis which triggers the duration of the wound to heal. <i>Rhodomyrtus tomentosa</i> leaves (haramonting) and <i>Zanthoxylum acanthopodium </i>fruits (andaliman) are an endemic plant with an antioxidant in Indonesia. This study was aimed to determine histology changes of diabetic wound healing in FGF expression by Nano herbal of haramonting and andaliman. <b>Materials and Methods:</b> This study consisted of 4 groups for each treatment, K<sub>1</sub>: Negative control, K<sub>2</sub>: MEBO, K<sub>3</sub>: Nano herbal of andaliman and K<sub>4</sub>: Nano herbal of haramonting. The treatments were observed on days 0, 4, 8, 12 and 16. Diabetic model rats with alloxan injection (120 mg kg<sup>1</sup>. IP) and rats were declared diabetes mellitus when blood glucose levels reached <u>></u>200 mg dL<sup>1</sup>. The tissue was prepared on paraffin blocks and given Immunohistochemistry staining for FGF analysis. <b>Results:</b> There was a significant difference between all groups (p<0.001) in FGF expression. The proliferation of fibroblasts and collagen was formed by administering nano herbal andaliman and haramonting in rat's skin. The proliferation of cells that occur in the injured skin layer indicates the compounds contained in the nano herbal haramonting and andaliman stimulate cell division and growth to form wound tissue. <b>Conclusion:</b> Nano herbal andaliman and haramonting can be developed into herbs that can be used to treat wounds in diabetes. Another molecular gene analysis is required to get higher yields to further study for diabetic wounds against these two herbs.