Acupuncture versus pharmacological conversation in treatment of atrial fibrillation in a randomized controlled trial: a systemic review and meta-analysis.

OBJECTIVE: This study aimed to investigate the effect of conventional drugs combined with acupuncture therapy on the conversion of sinus rhythm in patients with atrial fibrillation. METHODS: We searched databases, such as PubMed, Embase, WOS, Cochrane, CNKI (China National Knowledge Infrastructure), Wan fang Data, VIP, and CBM to collect data in randomized controlled trials of acupuncture included patients with atrial fibrillation. Publication time was limited from the beginning to May 15, 2021. The primary outcome is the number of participants who converted successfully. RESULTS: A total of 11 papers were included in this study. The combined effect indicated that acupuncture significantly effectively benefitted the patients with atrial fibrillation (RR = 1.208, 95% CI 1.123, 1.298, P < 0.001). Further subgroup analysis of persistent and paroxysmal atrial fibrillation and the timing of acupuncture suggested that the addition of acupuncture was not statistically significant in the treatment of persistent AF compared to the control group (RR = 1.147, 95% CI 0.811, 1.623 P = 0.147). The combination of acupuncture was more effective in paroxysmal AF RR = 1.148 (95% CI 1.064, 1.239) P < 0.001. In addition, when the acupuncture time was limited to 20 min, it had the best treatment effect (RR = 1.510, 95% CI 1.25, 1.82). CONCLUSIONS: The combination of pharmacological resuscitation with acupuncture significantly improved the conversion of paroxysmal atrial fibrillation compared to pharmacological resuscitation only. The most significant benefit was achieved with an acupuncture duration of < 20 min. Thus, the combination of acupuncture could be considered in clinical practice for the resuscitation of patients with atrial fibrillation.

phoH-carrying virus communities responded to multiple factors and their correlation network with prokaryotes in sediments along Bohai Sea, Yellow Sea, and East China Sea in China.

Viruses carrying phoH genes are an important functional group that may boost phosphate metabolism of their prokaryote hosts and affect phosphorus cycle in the ocean. However, at present, very little is known about the phoH-carrying viruses' community structure and diversity in marine sediments, as well as their correlation network with prokaryotes and environment. Here, via a large spatial scale investigation along the Bohai Sea, Yellow Sea, and East China Sea, for the first time, diverse unknown benthic phoH-carrying viruses were uncovered, which were mainly affiliated to three clusters. Interestingly, these viruses presented a very distinct community structure compared to those in seawaters. Correlation network analysis implied that these viruses might mainly infect the prokaryotes of Gamm-/Delta-proteobacteria, Thaumarchaeota, and Cyanobacteria in sediments. Distinct virus-prokaryote correlation network modules were shown in different sea areas. These modules' highly nested feature implied their coevolution with prokaryotes during long-term arms race. Their distribution in sediments was influenced by multiple factors including geographic separation and the key environmental variables of total organic carbon and total phosphorus, and responded to terrestrial inputs and coastal aquaculture activities. The results of this study provide novel insights into the benthic virus communities potentially participating in phosphorus cycling in the ocean.

Environmental characteristics in three seamount areas of the Tropical Western Pacific Ocean: Focusing on nutrients.

Nutrients distribution and influencing factors in three seamount areas named Y3, M2 and C4 of the Tropical Western Pacific Ocean (TWPO) were investigated. Nutrients showed obvious uplifts around the three seamounts, consistent with the uplifts of isotherms and isohalines, indicating the existence of a bottom-up process of nutrients. Meanwhile, compared with the stations away from seamount and the reference stations in the TWPO, nutrients concentrations around seamount were much higher. Among the three seamounts, the average nutrients concentrations were highest in Y3, while they were lowest in C4. Moreover, compared with the obvious nitrogen limitation in Y3 and M2, the N:P (13.5:1) and Si:N (6.1:1) were closed to the Redfield ratio. The current-seamount interaction was the determining influencing factor on nutrients distribution, causing the hydrology dynamic changes such as uplifts and Taylor column. Meanwhile, T and S also affected nutrients distribution, especially nutrients and T showed significant negative correlations.

Occurrence and origins of biomarker aliphatic hydrocarbons and their indications in surface sediments of the East China Sea.

The composition, distribution, indexes and budget of saturated lipid biomarker aliphatic hydrocarbons (AHs) in sediments of the East China Sea (ESC) were analyzed to identify their indications and sources. The resolved n-alkane (R) contents were 0.70-2.89 µg/g, with long-chain n-alkanes as the dominant composition in the ECS. The high R values mainly appeared at south inner shelf and north outer upwelling area, corresponding to the high mud, total organic carbon (TOC) and Chl a contents there. The composition, distribution pattern, combined with indexes of AHs, suggested no petroleum contamination and predominant biogenic sources in the ECS. The biogenic sources mainly were the mixed terrestrial higher plant, marine plankton and bacteria and aquatic macrophyte origins. Biotic source apportionment suggested that terrestrial higher plants were the dominant source of AHs, followed by marine planktons, with the lowest of submerged/floating macrophytes. Quantitative evaluation of R sources suggested that the Changjiang River input was the primary terrestrial contributor, accounting for 67.9% of total terrestrial input. The burial flux of R was 1.11 × 103 t/yr, with inner shelf and estuary as main accumulation areas. Although there was a huge amount of R influx from terrestrial and marine sources, only 9.8% could be preserved in sediments.

[Release and supplement of carbon, nitrogen and phosphorus from jellyfish (Nemopilema nomurai) decomposition in seawater].

Abstract: Jellyfish bloom has been increasing in Chinese seas and decomposition after jellyfish bloom has great influences on marine ecological environment. We conducted the incubation of Nemopilema nomurai decomposing to evaluate its effect on carbon, nitrogen and phosphorus recycling of water column by simulated experiments. The results showed that the processes of jellyfish decomposing represented a fast release of biogenic elements, and the release of carbon, nitrogen and phosphorus reached the maximum at the beginning of jellyfish decomposing. The release of biogenic elements from jellyfish decomposition was dominated by dissolved matter, which had a much higher level than particulate matter. The highest net release rates of dissolved organic carbon and particulate organic carbon reached (103.77 ± 12.60) and (1.52 ± 0.37) mg · kg⁻¹ · h⁻¹, respectively. The dissolved nitrogen was dominated by NH4⁺-N during the whole incubation time, accounting for 69.6%-91.6% of total dissolved nitrogen, whereas the dissolved phosphorus was dominated by dissolved organic phosphorus during the initial stage of decomposition, being 63.9%-86.7% of total dissolved phosphorus and dominated by PO4³â»-P during the late stage of decomposition, being 50.4%-60.2%. On the contrary, the particulate nitrogen was mainly in particulate organic nitrogen, accounting for (88.6 ± 6.9) % of total particulate nitrogen, whereas the particulate phosphorus was mainly in particulate. inorganic phosphorus, accounting for (73.9 ±10.5) % of total particulate phosphorus. In addition, jellyfish decomposition decreased the C/N and increased the N/P of water column. These indicated that jellyfish decomposition could result in relative high carbon and nitrogen loads.

Environmental radionuclides in a coastal wetland of the Southern Laizhou Bay, China.

The radioactivity concentration of (238)U, (232)Th, (226)Ra, (40)K, and (137)Cs in soil samples collected in a coastal wetland of the Southern Laizhou Bay, China were measured. Mean activity concentrations were 54.4±11.7, 57.9±9.7, 28.6±4.3, 542±21, and 10.2±2.9Bqkg(-1) dry weight for (238)U, (232)Th, (226)Ra, (40)K and (137)Cs, respectively. Statistical analyses suggested significant correlations between clay content and (40)K as well as (137)Cs. The radium equivalent activity, the absorbed dose rate in the air at 1m above the ground surface, and the external hazard index were calculated. The result showed that the radioactivity level in the wetland was in normal range. But sites along the river tended to have higher radiological hazard indexes. The vertical distributions of radionuclides in profiles illustrated some phenomena, such as vertical transport of (238)U, disequilibrium between (238)U and (226)Ra, and change in material sources.

Jellyfish (Cyanea nozakii) decomposition and its potential influence on marine environments studied via simulation experiments.

A growing body of evidence suggests that the jellyfish population in Chinese seas is increasing, and decomposition of jellyfish strongly influences the marine ecosystem. This study investigated the change in water quality during Cyanea nozakii decomposition using simulation experiments. The results demonstrated that the amount of dissolved nutrients released by jellyfish was greater than the amount of particulate nutrients. NH4(+) was predominant in the dissolved matter, whereas the particulate matter was dominated by organic nitrogen and inorganic phosphorus. The high N/P ratios demonstrated that jellyfish decomposition may result in high nitrogen loads. The inorganic nutrients released by C. nozakii decomposition were important for primary production. Jellyfish decomposition caused decreases in the pH and oxygen consumption associated with acidification and hypoxia or anoxia; however, sediments partially mitigated the changes in the pH and oxygen. These results imply that jellyfish decomposition can result in potentially detrimental effects on marine environments.

Linking the toxic metals to benthic community alteration: a case study of ecological status in the Bohai Bay.

Ecological effects and quality status of sediments in the Bohai Bay (North China) were studied by incorporating the traditional chemical analysis and benthic community structure. In the present study, paired sediments from 20 stations were sampled for chemical analysis and benthic assemblages. The overall results demonstrated that sediment impairment mainly appeared in the southern part of the Bay. The results obtained from the principal component analysis regarding benthic data and potential explanatory factors indicated that As, Hg and petroleum hydrocarbons (PHs) were responsible for the distribution of macrofaunal assemblages. Canonical correspondence analysis further showed As was significantly correlated to the benthic alteration, which provided evidence of ecological relevance to chemical substances of concern. Overall, this study revealed the metal contamination in the Bohai Bay was not as severe as previously regarded. Yet, further investigation is still needed considering the complexity of sediment matrices.

[Causes of jellyfish blooms and their influence on marine environment].

Jellyfish blooms have damaged the normal composition and function of marine ecosystem and ecological environments, which have been one of the new marine ecological disasters. In this study, we summarized the possible inducements of jellyfish blooms, and the influences of jellyfish blooms on biogenic elements, dissolved oxygen, seawater acidity and biological community were discussed emphatically. The results showed that jellyfish blooms had a close contact with its physiological structure and life history, which had favorable characteristics including simple body struc- ture, rapid growth, thriving reproduction and short generation interval to tolerate harsh environment better. Jellyfish abundance increased rapidly when it encountered suitable conditions. The temperature variations of seawater might be the major inducing factor which could result in jellyfish blooms. Jellyfish blooms may benefit from warmer temperature that could increase the food availability of jellyfish and promote jellyfish reproduction, especially for warm temperate jellyfish species. Eutrophication, climate change, overfishing, alien invasions and habitat modification were all possible important contributory factors of jellyfish blooms. Jellyfish could significantly influence the form distribution and biogeochemical cycling of biogenic elements. Jellyfish excreted NH4+ and P04(3-) at a rate of 59.1-91.5 micromol N x kg(-1) x h(-1) and 1.1-1.8 micromol P x kg(-1) x h(-1), which could meet about 8%-10% and 21.6% of the phytoplankton primary production requirement of N and P, respectively. Live jellyfish released dissolved organic carbon (DOC) at a rate of 1.0 micromol C x g(-1) x d(-1). As jellyfish decomposing, the effluxes of total N and total P were 4000 micromol N x kg(-1) x d(-1) and 120 micromol P x kg(-1) x d(-1), respectively, while the efflux of DOC reached 30 micromol C x g(-1) x d(-1). Jellyfish decomposition could cause seawater acidification and lowered level of dissolved oxygen and finally made the ambient water become acidic and hypoxic. The pH decreased by 1.3, while the mean dissolved oxygen demand reached 32.8 micromol x kg(-1) x h(-1). Jellyfish blooms also influenced the marine organism community, which might reduce the biomass of some fish and zooplankton, increase the amount of bacterioplankton, indirectly .increase the quantity of phytoplankton and lead to abnormal primary production.

Astragalus injection protects cerebral ischemic injury by inhibiting neuronal apoptosis and the expression of JNK3 after cerebral ischemia reperfusion in rats.

BACKGROUND: Astragalus is a widely used traditional Chinese medicine and has been proven beneficial for many aspects of human health. It is important to explore the neuroprotective effect and mechanism of astragalus injection in cerebral ischemia reperfusion injury. METHODS: The focal cerebral ischemic model with middle cerebral artery occlusion (MCAO) reperfusion was established by Longa's method in healthy adult male Wistar rats, and treated by injecting intraperitoneally astragalus injection (3 ml/kg). The neurobehavioral function of rats was evaluated by Longa's test. The cerebral blood flow (CBF) was measured by laser Doppler flowmetry and the cerebral infarct volume was calculated by tetrazolium chloride (TTC) stain. The shape and structure of neurons in parahippocampal area was observed by HE stain and the neuronal apoptosis was detected by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) and flow cytometry. The expressions of c-jun N-terminal kinase 3 (JNK3) mRNA and protein were determined by RT-PCR and immunohistochemical assay and Western blotting respectively. RESULTS: After treatment with astragalus injection, the expressions of JNK3 mRNA and protein reduced significantly, the number of neuronal apoptosis minus, the cerebral infarct volume shrink, the neuronal shape-structure and animal neurobehavioral function improved significantly than those in model rats. CONCLUSIONS: It is suggested that astragalus injection could inhibit neuronal apoptosis, reduce infarct volume and improve neurobehavioral function by down-regulating the expression of JNK3 gene after cerebral ischemia reperfusion injury in rats.

Environmental significance of biogenic elements in surface sediments of the Changjiang Estuary and its adjacent areas.

Biogenic elements and six phosphorus (P) fractions in surface sediments from the Changjiang Estuary and adjacent waters were determined to investigate the governing factors of these elements, and further to discuss their potential uses as paleo-environment proxies and risks of P release from sediment. Total organic carbon (TOC) and leachable organic P (Lea-OP) showed high concentrations in the estuary, Zhejiang coast and offshore upwelling area. They came from both the Changjiang River and marine biological input. Biogenic silicon (BSi) exhibited a high concentration band between 123 and 124 degree E. BSi mainly came from diatom production and its concentration in the inshore area was diluted by river sediment. Total nitrogen (TN) was primarily of marine biogenic origin. Seaward decreasing trends of Fe-bound P and Al-bound P revealed their terrestrial origins. Influenced by old Huanghe sediment delivered by the Jiangsu coastal current, the maximum concentration of detrital P (Det-P) was observed in the area north of the estuary. Similar high concentrations of carbonate fluorapatite (CFA-P) and CaCO3in the southern study area suggested marine calcium-organism sources of CFA-P. TOC, TN and non-apatite P were enriched in fine sediment, and Det-P partially exhibited coarse-grain enrichment, but BSi had no correlation with sediment grain size. Different sources and governing factors made biogenic elements and P species have distinct potential uses in indicating environmental conditions. Transferable P accounted for 14%-46% of total P. In an aerobic environment, there was low risk of P release from sediment, attributed to excess Fe oxides in sediments.

Petroleum hydrocarbons and their effects on fishery species in the Bohai Sea, North China.

Systematic studies on the changes in concentrations of petroleum hydrocarbons (PHs) and their effects on fishery species in the Bohai Sea during 1974-2004 are presented. Changes in PHs concentrations were closely related to Yellow River runoff. Concentrations of PHs accumulated in fish and shrimp increased by about 0.712 mg/kg dry weight when trophic level of fish and shrimps increased by 1. Attention should also be paid to the high PHs concentrations in mollusks along the coastal waters of the Bohai Sea. Average concentration of PHs in the adjacent coastal waters of Tianjin City during 1996-2005 decreased the population growth rates of fish, crustaceans and mollusks in the Bohai Sea by 2.58%, 6.59% and 2.33%, respectively. Therefore, PHs have significantly contributed to the decline in fisheries in the Bohai Sea, and they must be reduced to realize the sustainable fisheries.

[Sediment record of phosphorus and the primary study of its bioavailability in Jiaozhou Bay sediments].

The geochemical characteristics of phosphorus forms in different grain size sediments, the influencing factors as well as the bioavailability of phosphorus in Jiaozhou Bay were investigated employing the sequential extraction method. The results showed that inorganic phosphorus was the dominant form of total phosphorus and organic phosphorus was only the minor part. The detrital carbonate-bound phosphorus was the largest part of total phosphorus. The grain size, organic carbon, temperature, pH and etc. are the main controlling factors of phosphorus in sediments. Except for Ca-P, most of other phosphorus forms contents increased as the grain size decreased. The bioavailability research showed that the bioavailable phosphorus was mainly the exchangeable phosphorus, phosphorus bound to Al and Fe and organic phosphorus. Moreover, the potential bioavailable phosphorus proportion in total phosphorus increased as the grain size decreased. The bioavailable phosphorus in different grain size sediments has positive correlationship with phytoplankton abundance and phosphate in overlying water.

[Phosphorus and its environmental marker function in Jiaozhou Bay sediments].

Phosphorus is a key biogenic element and plays an essential role in global biogeochemical cycles. The geochemical characteristics of phosphorus as well as the controlling factors and the environmental marker function in Jiaozhou Bay sediments were presented. The different forms of sedimentary phosphorus were studied in three sediment cores, which are forms of inorganic phosphorus, exchangeable phosphorus, phosphorus bound to Al-Fe, and calcium, occluded phosphorus as well as total phosphorus and organic phosphorus, respectively. The vertical profiles of various forms of phosphorus in response to 210Pb chronological studies of sediment cores were investigated in order to reveal sedimentary environment changes. The results showed that inorganic phosphorus was the dominant form of total phosphorus and organic phosphorus was only the minor part. The detrital carbonate-bound phosphorus was the largest part of total phosphorus. The concentrations and burial fluxes of phosphorus were controlled by source and environmental factors including pH, salinity, temperature and grain size of sediments etc. Moreover, the analysis of OC/OP ratios suggested that the terrestrial inputs were the dominant source of Jiaozhou Bay sediments. The sedimentation fluxes of phosphorus increased in the past two decades, as a result, the pollution was still serious from the 1980 to 2000. But the state has greatly improved since 2000. The Fe-P, Al-P and Oc-P have close relationships with the degree of pollution and may act as good indicators for environment pollution in Jiaozhou Bay.