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Métodos Terapéuticos y Terapias MTCI
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Molecules ; 25(19)2020 Oct 06.
Artículo en Inglés | MEDLINE | ID: mdl-33036315

RESUMEN

Trypanosomiases are diseases caused by parasitic protozoan trypanosomes of the genus Trypanosoma. In humans, this includes Chagas disease and African trypanosomiasis. There are few therapeutic options, and there is low efficacy to clinical treatment. Therefore, the search for new drugs for the trypanosomiasis is urgent. This review describes studies of the trypanocidal properties of essential oils, an important group of natural products widely found in several tropical countries. Seventy-seven plants were selected from literature for the trypanocidal activity of their essential oils. The main chemical constituents and mechanisms of action are also discussed. In vitro and in vivo experimental data show the therapeutic potential of these natural products for the treatment of infections caused by species of Trypanosoma.


Asunto(s)
Enfermedad de Chagas/tratamiento farmacológico , Aceites Volátiles/uso terapéutico , Animales , Humanos , Extractos Vegetales/uso terapéutico , Tripanocidas/uso terapéutico , Trypanosoma brucei brucei/efectos de los fármacos , Trypanosoma brucei brucei/patogenicidad , Trypanosoma cruzi/efectos de los fármacos , Trypanosoma cruzi/patogenicidad , Tripanosomiasis Africana/tratamiento farmacológico
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