Asunto(s)
Fluorouracilo/administración & dosificación , Neoplasias/tratamiento farmacológico , Adulto , Anciano , Plaquetas/efectos de los fármacos , Ensayos Clínicos como Asunto , Relación Dosis-Respuesta a Droga , Fluorouracilo/farmacología , Fluorouracilo/uso terapéutico , Humanos , Infusiones Parenterales , Leucocitos/efectos de los fármacos , Persona de Mediana Edad , Cuidados PaliativosRESUMEN
Six patients with chronic granulocytic leukaemia (CGL) in transformation were treated with cytotoxic drugs or cytotoxic drugs plus total body irradiation, followed by infusion of reconstituted autologous peripheral blood cells that had been collected from them at diagnosis and stored in liquid nitrogen for up to 58 months. In four cases the blood and bone-marrow appearances were rapidly restored to those of typical chronic-phase disease. In three of these patients transformation recurred at 74, 32, and 26 weeks respectively. One patient was still in second chronic phase at eight weeks. One of the patients who entered a second transformation was restored to a third chronic phase by further treatment with cytotoxic drugs and a second autograft. Cryopreserved autologous blood cells may thus restore some patients with CGL in transformation to chronic-phase disease and so may help to prolong life.