RESUMEN
A new diarylhexane, kneglobularone B (1) and two new diarylpropanols, kneglobularols A - B (2 - 3) along with seven known compounds (4 - 10) were isolated and characterized from the roots of Knema globularia. It is the first time to find arylpropyl quinone (4) and isoflavone (8) in Myristicaceae family. In addition, 5 was found for the first time in Knema genus. Their structures were elucidated by UV, IR, MS, 1 D and 2 D NMR techniques. Compound 4 exhibited strong cytotoxicity against the NCI - H187 and MCF - 7 cell lines with IC50 values of 3.08 and 6.68 µg/mL, respectively.
Asunto(s)
Myristicaceae , Plantaginaceae , Línea Celular Tumoral , Humanos , Células MCF-7 , Estructura Molecular , Myristicaceae/química , Extractos Vegetales/química , Raíces de Plantas/químicaRESUMEN
Four new compounds, microminutin B (1), microminutin C (2), micromarinate (3), and secomicromelin (4) as well as 17 known compounds were isolated from the fruits of Micromelum falcatum. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. P. insidiosum is a fungus-like microorganism for which antifungal agents now available are not effective. The results show that four compounds including secomicromelin (4), 7-methoxy-8-(4'-methyl-3'-furanyl)coumarin (10), micromarin B (17), and isomicromelin (19) could inhibit the mycelia growth of P. insidiosum.
Asunto(s)
Antifúngicos/química , Cumarinas/química , Extractos Vegetales/química , Pythium/efectos de los fármacos , Rutaceae/química , Antifúngicos/aislamiento & purificación , Antifúngicos/farmacología , Cumarinas/aislamiento & purificación , Cumarinas/farmacología , Relación Dosis-Respuesta a Droga , Frutas/química , Espectroscopía de Resonancia Magnética , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/farmacología , Pythium/crecimiento & desarrolloRESUMEN
Three new lignan esters, alyterinates A-C (1-3), as well as 10 known compounds were isolated from the roots of Alyxia schlechteri. Antifungal activity against Pythium insidiosum of all lignan derivatives was evaluated using disk diffusion assay. P. insidiosum is not a true fungus since its cell walls do not contain ergosterol as usual fungi, so the antifungals available now are not effective. From activity testing, it was found that compounds 3, 4 and 5 could inhibit the mycelia growth of P. insidiosum.
Asunto(s)
Antifúngicos/farmacología , Apocynaceae/química , Lignanos/farmacología , Extractos Vegetales/farmacología , Pythium/efectos de los fármacos , Antifúngicos/aislamiento & purificación , Lignanos/aislamiento & purificación , Extractos Vegetales/aislamiento & purificación , Raíces de Plantas/químicaRESUMEN
A new carbazole alkaloid named clauraila E (1) together with 8 known compounds were isolated from the methanol extract of the roots of Clausena harmandiana. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. Pythium insidiosum is a fungus-like microorganism, for which antifungals available now are not effective. It was found that compounds 3, 6, 7 and 9 could inhibit the mycelia growth of P. insidiosum. The results show convincingly that they may be lead to compounds for the development of probiotic or novel antifungal drugs.