1.
Systematic Identification of Thiosemicarbazides for Inhibition of Toxoplasma gondii Growth In Vitro.
Molecules
; 24(3)2019 Feb 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30744161
RESUMEN
One of the key stages in the development of new therapies in the treatment of toxoplasmosis is the identification of new non-toxic small molecules with high specificity to Toxoplasma gondii. In the search for such structures, thiosemicarbazide-based compounds have emerged as a novel and promising leads. Here, a series of imidazole-thiosemicarbazides with suitable properties for CNS penetration was evaluated to determine the structural requirements needed for potent anti-Toxoplasma gondii activity. The best 4-arylthiosemicarbazides 3 and 4 showed much higher potency when compared to sulfadiazine at concentrations that are non-toxic to the host cells, indicating a high selectivity of their anti-toxoplasma activity.