RESUMEN
In this issue of Blood, complementary studies by Amin et al and Linley et al demonstrate that sugar moieties linked to surface immunoglobulin (sIg) of follicular lymphoma (FL) cells directly interact with endogenous lectins within the lymphoma niche and lead to activation of downstream B-cell receptor (BCR) signaling pathways. In addition to providing further insight into the role of the microenvironment in lymphomagenesis, these findings expose a unique molecular interaction that may represent a viable target for therapeutic intervention.
Asunto(s)
Linfocitos B/metabolismo , Señalización del Calcio , Moléculas de Adhesión Celular/inmunología , Moléculas de Adhesión Celular/metabolismo , Regulación de la Expresión Génica/inmunología , Inmunoglobulina M/inmunología , Región Variable de Inmunoglobulina/metabolismo , Lectinas Tipo C/inmunología , Lectinas Tipo C/metabolismo , Linfoma Folicular/inmunología , Linfoma Folicular/metabolismo , Sistema de Señalización de MAP Quinasas , Macrófagos/inmunología , Receptores de Antígenos de Linfocitos B/inmunología , Receptores de Superficie Celular/inmunología , Receptores de Superficie Celular/metabolismo , Transducción de Señal/inmunología , Femenino , Humanos , MasculinoRESUMEN
Although the majority of published cases of lead poisoning come from occupational exposures, some traditional remedies may also contain toxic amounts of lead. Ayurveda is a system of traditional medicine that is native to India and is used in many parts of world as an alternative to standard treatment regimens. Here, we report the case of a 58-year-old woman who presented with abdominal pain, anemia, liver function abnormalities, and an elevated blood lead level. The patient was found to have been taking the Ayurvedic medicine Jambrulin prior to presentation. Chemical analysis of the medication showed high levels of lead. Following treatment with an oral chelating agent, the patient's symptoms resolved and laboratory abnormalities normalized. This case highlights the need for increased awareness that some Ayurvedic medicines may contain potentially harmful levels of heavy metals and people who use them are at risk of developing associated toxicities.