Brain-Heart Interactions Underlying Traditional Tibetan Buddhist Meditation.

Despite accumulating evidence suggesting improvement in one's well-being as a result of meditation, little is known about if or how the brain and the periphery interact to produce these behavioral and mental changes. We hypothesize that meditation reflects changes in the neural representations of visceral activity, such as cardiac behavior, and investigated the integration of neural and visceral systems and the spontaneous whole brain spatiotemporal dynamics underlying traditional Tibetan Buddhist meditation. In a large cohort of long-term Tibetan Buddhist monk meditation practitioners, we found distinct transient modulations of the neural response to heartbeats in the default mode network (DMN), along with large-scale network reconfigurations in the gamma and theta bands of electroencephalography (EEG) activity induced by meditation. Additionally, temporal-frontal network connectivity in the EEG theta band was negatively correlated with the duration of meditation experience, and gamma oscillations were uniquely, directionally coupled to theta oscillations during meditation. Overall, these data suggest that the neural representation of cardiac activity in the DMN and large-scale spatiotemporal network integrations underlie the fundamental neural mechanism of meditation and further imply that meditation may utilize cortical plasticity, inducing both immediate and long-lasting changes in the intrinsic organization and activity of brain networks.

Three-Dimensional Brain-Computer Interface Control Through Simultaneous Overt Spatial Attentional and Motor Imagery Tasks.

OBJECTIVE: While noninvasive electroenceph-alography (EEG) based brain-computer interfacing (BCI) has been successfully demonstrated in two-dimensional (2-D) control tasks, little work has been published regarding its extension to practical three-dimensional (3-D) control. METHODS: In this study, we developed a new BCI approach for 3-D control by combining a novel form of endogenous visuospatial attentional modulation, defined as overt spatial attention (OSA), and motor imagery (MI). RESULTS: OSA modulation was shown to provide comparable control to conventional MI modulation in both 1-D and 2-D tasks. Furthermore, this paper provides evidence for the functional independence of traditional MI and OSA, as well as an investigation into the simultaneous use of both. Using this newly proposed BCI paradigm, 16 participants successfully completed a 3-D eight-target control task. Nine of these subjects further demonstrated robust 3-D control in a 12-target task, significantly outperforming the information transfer rate achieved in the 1-D and 2-D control tasks (29.7 ± 1.6 b/min). CONCLUSION: These results strongly support the hypothesis that noninvasive EEG-based BCI can provide robust 3-D control through endogenous neural modulation in broader populations with limited training. SIGNIFICANCE: Through the combination of the two strategies (MI and OSA), a substantial portion of the recruited subjects were capable of robustly controlling a virtual cursor in 3-D space. The proposed novel approach could broaden the dimensionality of BCI control and shorten the training time.