RESUMEN
Melanoma is a primary reason of death from skin cancer and associated with high lethality. Photothermal therapy (PTT) has been developed into a powerful cancer treatment technique in recent years. Here, we created a low-cost and high-performance PTT agent, Ag@TiO2 NPs, which possesses a high photothermal conversion efficiency of ≈65 % and strong near-infrared (NIR) absorption about 808â nm. Ag NPs were synthesized using a two-step method and coated with TiO2 to obtain Ag@TiO2 NPs by a facile sol-gel method. Because of the oxide, Ag@TiO2 NPs exhibit remarkable high photothermal conversion efficiencies and biocompatibility in vivo and in vitro. Cytotoxicity and therapeutic efficiency of photothermal cytotoxicity of Ag@TiO2 NPs were tested in B16-F10 cells and C57BL/6J mice. Under light irradiation, the elevated temperature causes cell death in Ag NPs-treated (100â µg mL-1 ) cells in vitro (both p<0.01). In the case of subcutaneous melanoma tumor model, Ag@TiO2 NPs (100â µg mL-1 ) were injected into the tumor and irradiated with a 808â nm laser of 2â W cm-2 for 1â minute. As a consequence, the tumor volume gradually decreased by NIR laser irradiation with only a single treatment. The results demonstrate that Ag@TiO2 NPs are biocompatible and an attractive photothermal agent for cutaneous melanoma by local delivery.
Asunto(s)
Antineoplásicos/farmacología , Melanoma/terapia , Nanopartículas/química , Fototerapia , Plata/farmacología , Titanio/química , Animales , Antineoplásicos/química , Muerte Celular/efectos de los fármacos , Supervivencia Celular/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Ensayos de Selección de Medicamentos Antitumorales , Rayos Infrarrojos , Melanoma/patología , Ratones , Ratones Endogámicos C57BL , Tamaño de la Partícula , Plata/química , Relación Estructura-Actividad , Titanio/farmacología , Células Tumorales CultivadasRESUMEN
Hollow metallic nanostructures exhibit important applications in catalysis, sensing, and phototherapy due to their increased surface areas, reduced densities, and unique optical and electronic features. Here we report a facile photocatalytic process to synthesize and tune hollow platinum (Pt) nanostructures. Through hierarchically structured templates, well-defined hollow Pt nanostructures are achieved. These nanostructures possess interconnected nanoporous framework as shell with high surface area for enhanced catalytic performance/mass transport for methanol oxidation.