RESUMEN
A new diarylhexane, kneglobularone B (1) and two new diarylpropanols, kneglobularols A - B (2 - 3) along with seven known compounds (4 - 10) were isolated and characterized from the roots of Knema globularia. It is the first time to find arylpropyl quinone (4) and isoflavone (8) in Myristicaceae family. In addition, 5 was found for the first time in Knema genus. Their structures were elucidated by UV, IR, MS, 1 D and 2 D NMR techniques. Compound 4 exhibited strong cytotoxicity against the NCI - H187 and MCF - 7 cell lines with IC50 values of 3.08 and 6.68 µg/mL, respectively.
Asunto(s)
Myristicaceae , Plantaginaceae , Línea Celular Tumoral , Humanos , Células MCF-7 , Estructura Molecular , Myristicaceae/química , Extractos Vegetales/química , Raíces de Plantas/químicaRESUMEN
A new flavonoid, atalantraflavone (1) as well as eight known compounds including atalantoflavone (2), racemoflavone (3), 5,4'-dihydroxy-(3â³,4â³-dihydro-3â³,4â³-dihydroxy)-2â³,2â³-dimethylpyrano-(5â³,6â³:7,8)-flavone (4), lupalbigenin (5), anabellamide (6), citrusinine I (7), p-hydroxybenzaldehyde (8), and frideline (9), were isolated from the leaves of Atalantia monophylla (L.) DC. Focusing on Alzheimer's disease, acetylcholine esterase (AChE) inhibition and antioxidant activity were evaluated using the modified Ellman's method and the ABTS scavenging assay, respectively. It was found that isoflavonoid 5, lupalbigenin, showed 79% inhibition to AChE and was 1.4-fold stronger than the tacrine standard. In addition, acridone 7, citrusinine I, displayed 90.68% antioxidant activity.
Asunto(s)
Antioxidantes/farmacología , Inhibidores de la Colinesterasa/farmacología , Flavonoides/farmacología , Rutaceae/química , Acridonas/química , Acridonas/farmacología , Alcaloides/química , Alcaloides/farmacología , Antioxidantes/química , Inhibidores de la Colinesterasa/química , Evaluación Preclínica de Medicamentos/métodos , Flavonoides/química , Isoflavonas/química , Isoflavonas/farmacología , Espectroscopía de Resonancia Magnética , Estructura Molecular , Extractos Vegetales/farmacología , Hojas de la Planta/químicaRESUMEN
Two new compounds, derrivanone (1) and derrischalcone (2), were isolated from the crude hexane extract of the fruits of Derris indica. In addition, 14 known compounds were isolated from the fruits of this plant. Chalcones 2-4 showed strong cytotoxicity against cholangiocarcinoma cell line (M156) and human hepatoma HepG2 cells. In addition, flavanones 15 and 16 exhibited potent and high cytotoxic efficacy.
Asunto(s)
Antineoplásicos/química , Antineoplásicos/toxicidad , Derris/química , Antineoplásicos/uso terapéutico , Neoplasias de los Conductos Biliares/tratamiento farmacológico , Conductos Biliares Intrahepáticos , Línea Celular Tumoral , Chalconas/química , Colangiocarcinoma/tratamiento farmacológico , Flavanonas/química , Flavanonas/toxicidad , Frutas/química , Células Hep G2 , Humanos , Extractos Vegetales/químicaRESUMEN
Four new compounds, microminutin B (1), microminutin C (2), micromarinate (3), and secomicromelin (4) as well as 17 known compounds were isolated from the fruits of Micromelum falcatum. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. P. insidiosum is a fungus-like microorganism for which antifungal agents now available are not effective. The results show that four compounds including secomicromelin (4), 7-methoxy-8-(4'-methyl-3'-furanyl)coumarin (10), micromarin B (17), and isomicromelin (19) could inhibit the mycelia growth of P. insidiosum.