[Efficacy of enterocin S760 in treatment of mice with anthrax infection due to Bacillus anthracis M-71].

The therapeutic efficacy of enterocin S760, a broad spectrum antimicrobial peptide produced by Enterococcus faecium LWP760 was tested on mice infected with Bacillus anthracis M-71 to induce anthrax (second Tsenkovsky's vaccine). Intraperitoneal four-, two- or one-fold administration of the peptide in a dose of 25 mg/kg for 10 days for prophylactic (1 hour after the contamination) and therapeutic (24 hours after the contamination) purposes prevented or cured the infection in 90-100% of the mice versus the 100-percent lethality in the control (untreated animals). The antimicrobial activity of enterocin S760 against B. anthracis M-71 in vivo correlated with activity in vitro. Enterocin S760 is considered a novel promising antimicrobial for the treatment of grampositive and gramnegative infections.

[Use of enterocin S760 for prevention and treatment of experimental Salmonella infection in mice].

AIM: To demonstrate treatment efficacy of bacteriocin S760 synthesized by Enterococcus faecium 760 for septic Salmonella infection in mice. MATERIALS AND METHODS: One hundred mice, which were intraperitoneally inoculated with 100 LD50 of Salmonella enteritidis strain 92 Rif(r), received bacteriocin 1 hour (prevention) or 48 hours (treatment) after inoculation in doses 25, 50, or 100 mg/kg every 6 hours during 5 or 10 days. RESULTS: Use of peptide S760 for prophylaxis in dose 50 mg/kg during 10 days prevented lethal infection in 100% of animals, whereas its use for treatment cured 70% of animals with generalized salmonellosis. Shortening of treatment course from 10 to 5 days and reducing dose of bacteriocin led to less pronounced treatment effect but in all animals it was expressed by increase of mean length of life compared to control (not treated). CONCLUSION: Obtained results demonstrated high treatment efficacy of bacteriocin S760 during septic salmonellosis and perspectives of its use in medicine and animal health.

[Various indices of the infectious process in treatment of glanders in monkeys]. / Nekotorye pokazateli infektsionnogo protsessa pri terapii sapa u obez'ian.

The time course of the clinical, biochemical and serological indices was studied during the treatment of malleus in monkeys. The internal organs of the animals infected with Pseudomonas mallei were investigated pathomorphologically. The efficacy of the biseptol/oxalinic acid combination in the therapy of malleus was estimated.

[The efficacy of antibacterial preparations against Pseudomonas mallei in in-vitro and in-vivo experiments]. / Effektivnost' antibakterial'nykh preparatov v otnoshenii Pseudomonas mallei v opytakh in vitro i in vivo.

In vitro antibacterial activity of 43 antibiotics and chemotherapeutics against P. mallei Ts-5 was studied. The causative agent of malleus was highly susceptible to sulfanilamides, fluoroquinolones, tetracyclines, aminoglycosides, ceftazidime and imipenem. 15 antibiotics and chemotherapeutics were tested for their therapeutic efficacy on golden hamsters with experimental malleus. Combinations with trimetoprim (sulfaton and biseptol), 3rd generation quinolones (ciprofloxacin, enoxacin and ofloxacin) as well as minocycline, novobiocin and oxolinic acid were shown to be therapeutically highly efficient.