RESUMEN
PURPOSE: To show an association between T2-weighted signal intensity (T2-SI) variation and missegmentation in the putamen of healthy adults, using 3.0-tesla magnetic resonance scanner and voxel-based morphomery (VBM). MATERIALS AND METHODS: Contiguous sagittal T1-weighted images and axial T2-weighted images of the brain were obtained from 1380 healthy participants using a 3.0 Tesla (T) MR scanner. After image preprocessing with Statistical Parametric Mapping 5, the association between T2-SI ratio (= A/B, where A is the mean of the T2-SI in the putamen, and B is that in the thalamus) variation and gray matter missegmentation was assessed using VBM. RESULTS: A significant positive correlation was revealed between T2-SI ratio and bilateral putamen volume on the gray matter images. In addition, we found a significant negative correlation between T2-SI ratio and bilateral putamen volume on the white matter images. We consider that these results show the influence of missegmentation. CONCLUSION: To the best of our knowledge, this is the first VBM study to demonstrate an association between T2-SI variation and gray matter missegmentation. These results indicate the possibility that VBM may be more affected by individual differences in iron content levels than by individual differences in tissue volumes if detected-regions with VBM contained substantial iron deposition.
Asunto(s)
Ganglios Basales/patología , Encéfalo/patología , Hierro/química , Imagen por Resonancia Magnética , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Persona de Mediana Edad , Putamen/patología , Reproducibilidad de los Resultados , Tálamo/patologíaRESUMEN
PURPOSE: To evaluate the safety of using iodized oil in chemoembolization for liver tumors in patients with previous adverse reactions to iodinated contrast media. MATERIALS AND METHODS: Records were retrospectively reviewed for all patients with a history of an adverse reaction to iodinated contrast media who underwent angiography using gadolinium-based contrast media and/or carbon dioxide at our institution from January 1998 to September 2006. Patients who underwent chemoembolization or hepatic artery infusion for liver tumors using iodized oil were identified. RESULTS: There were 84 procedures with use of iodized oil performed in 36 patients. Mild adverse reactions potentially related to iodized oil were seen in two procedures (2.4%). There were no moderate or severe adverse reactions (0.0%). CONCLUSION: Iodized oil can be safely used in patients with previous adverse reactions to iodinated contrast media.
Asunto(s)
Carcinoma Hepatocelular/epidemiología , Carcinoma Hepatocelular/terapia , Quimioembolización Terapéutica/estadística & datos numéricos , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/epidemiología , Aceite Yodado/uso terapéutico , Neoplasias Hepáticas/epidemiología , Neoplasias Hepáticas/terapia , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma Hepatocelular/diagnóstico por imagen , Medios de Contraste , Femenino , Hemostáticos/uso terapéutico , Humanos , Incidencia , Yodo , Japón/epidemiología , Neoplasias Hepáticas/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Radiografía , Estudios Retrospectivos , Medición de Riesgo , Factores de RiesgoRESUMEN
A case of cerebral lipiodol embolism after transcatheter arterial chemoembolization (TACE) of hepatocellular carcinoma is presented. A 76-year-old man underwent TACE for advanced hepatocellular carcinoma. Immediately after chemoembolization, his level of consciousness deteriorated. Computed tomography revealed deposition of iodized oil in the cerebral cortex, basal ganglia, and thalami. Magnetic resonance imaging showed restricted diffusion within the thalami and basal ganglia. The patient's level of consciousness gradually improved, and all neurologic symptoms disappeared over 6 weeks.