Asunto(s)
Analgésicos Opioides/uso terapéutico , Hiperalgesia/tratamiento farmacológico , Meperidina/uso terapéutico , Oxicodona/uso terapéutico , Receptores de Quimiocina/antagonistas & inhibidores , Animales , Bencilaminas , Ciclamas , Evaluación Preclínica de Medicamentos/métodos , Sinergismo Farmacológico , Quimioterapia Combinada , Compuestos Heterocíclicos/uso terapéutico , Masculino , Maraviroc/uso terapéutico , Ratas Sprague-DawleyRESUMEN
Planarians are traditional animal models in developmental and regeneration biology. Recently, these organisms are arising as vertebrate-relevant animal models in neuropharmacology. Using an adaptation of published behavioral protocols, we have described the alleviation of cocaine-induced planarian seizure-like movements (pSLM) by a naturally-occurring sesquiterpene lactone, parthenolide. Interestingly, parthenolide does not prevent the expression of pSLM induced by amphetamines; in vertebrates, amphetamines interact with the same protein target as cocaine. Parthenolide is also unable to prevent pSLM elicited by the cholinergic com-pounds nicotine and cytisine or by the glutamatergic agents L- or D- glutamic acid or NMDA. Thus, we conclude that parthenolide is a specific anti-cocaine agent in this experimental organism.