RESUMEN
We investigated the effect of fish oil (FO) supplementation, at 4 g/day, on the respiratory performance and blood lipid profile of 32 patients with breast cancer at the beginning of chemotherapy. They were randomized into two groups: control (C) and FO supplemented (S). Both groups underwent three respiratory evaluations and blood harvest (before chemotherapy-Day 0, and 30 and 60 days after supplementation). The S group showed a significant increase in the maximal inspiratory and expiratory pressure (P ≤ 0.05 vs. Day 0) and in the maximum voluntary ventilation (P ≤ 0.05). In the treadmill 6-min-walk test, the S group had a significant increase in the walked distance (P ≤ 0.05). Blood lactate concentration was significantly lower in the S group after 60 days, at rest, when compared to C (P ≤ 0.05). Plasma high-density lipoprotein (HDL) cholesterol concentration remained the same after 60 days of supplementation, while in the C group, it decreased significantly (P ≤ 0.05 Day 0 vs. Day 60). Triacylglycerol (TAG) plasma concentration in the S group was lower when compared to the C group (P ≤ 0.05 Day 60S vs. Day 60). Supplementation with FO caused improvement in the respiratory muscle strength and endurance, ameliorated functional performance, and kept TAG, HDL cholesterol, and lactate plasma concentration at normal levels.
Asunto(s)
Antineoplásicos/efectos adversos , Neoplasias de la Mama/tratamiento farmacológico , Suplementos Dietéticos , Aceites de Pescado/uso terapéutico , Pulmón/efectos de los fármacos , Resistencia Física/efectos de los fármacos , Insuficiencia Respiratoria/prevención & control , Adulto , Antineoplásicos/uso terapéutico , Brasil , Neoplasias de la Mama/sangre , Neoplasias de la Mama/dietoterapia , Neoplasias de la Mama/cirugía , Quimioterapia Adyuvante/efectos adversos , HDL-Colesterol/sangre , Suplementos Dietéticos/efectos adversos , Prueba de Esfuerzo , Femenino , Aceites de Pescado/efectos adversos , Humanos , Ácido Láctico/sangre , Pulmón/fisiopatología , Persona de Mediana Edad , Fuerza Muscular/efectos de los fármacos , Cuidados Posoperatorios , Complicaciones Posoperatorias/inducido químicamente , Complicaciones Posoperatorias/fisiopatología , Complicaciones Posoperatorias/prevención & control , Reproducibilidad de los Resultados , Insuficiencia Respiratoria/inducido químicamente , Insuficiencia Respiratoria/etiología , Insuficiencia Respiratoria/fisiopatología , Músculos Respiratorios/efectos de los fármacos , Músculos Respiratorios/fisiopatología , Triglicéridos/sangreRESUMEN
PURPOSE: This study compared acute exercise responses during arm cranking, functional electrical stimulation (FES)-assisted leg cycling, and combined arm and leg ("hybrid") cycling in individuals with spinal cord injury during maximal and submaximal exercise. METHODS: Nine male subjects with long-standing neurological lesions from C7 to T12 were recruited. All subjects performed arm crank ergometry (ACE), FES leg cycle exercise (FES-LCE), combined ACE + FES-LCE, and cycling on a hybrid FES tricycle (HYBRID). They were assessed for their peak exercise responses in all four modalities. Subsequently, their submaximal heart rates (HR), cardiac outputs (Q), stroke volumes (SV), and arteriovenous oxygen extractions (Ca-Cv)O2 were measured at 40%, 60%, and 80% of mode-specific VËO2peak. RESULTS: Arm exercise alone and arm + leg exercise resulted in significantly higher VËO2peak and HRpeak compared with FES-LCE (P < 0.05). Submaximal VËO2 during FES-LCE was significantly lower than all other modalities across the range of exercise intensities (P < 0.05). ACE elicited 70%-94% higher steady-state VËO2, and HYBRID evoked 99%-148% higher VËO2 compared with FES-LCE. Steady-state FES-LCE also produced significantly lower Q, HR, and (Ca-Cv)O2. ACE evoked 31%-36% higher Q and 19%-47% greater HR than did FES-LCE. HYBRID elicited 31%-49% greater Q and 23%-56% higher HR than FES-LCE. CONCLUSIONS: Combined arm and leg exercise can develop a higher oxygen uptake and greater cardiovascular demand compared with ACE or FES-LCE alone. These findings suggested that combined arm + leg FES training at submaximal exercise intensities may lead to greater gains of aerobic fitness than would arm exercise alone. These data also proffered that FES leg cycling exercise by itself may be insufficient to promote aerobic fitness in the spinal cord injury population.
Asunto(s)
Terapia por Estimulación Eléctrica , Terapia por Ejercicio/métodos , Traumatismos de la Médula Espinal/terapia , Adolescente , Adulto , Anciano , Brazo , Vértebras Cervicales , Prueba de Esfuerzo , Humanos , Pierna , Masculino , Persona de Mediana Edad , Aptitud Física , Traumatismos de la Médula Espinal/fisiopatología , Vértebras Torácicas , Resultado del Tratamiento , Adulto JovenRESUMEN
BACKGROUND: Obesity is commonly associated with diabetes, cardiovascular diseases and cancer. The purpose of this study was to determinate the effect of a lower dose of fish oil supplementation on insulin sensitivity, lipid profile, and muscle metabolism in obese rats. METHODS: Monosodium glutamate (MSG) (4 mg/g body weight) was injected in neonatal Wistar male rats. Three-month-old rats were divided in normal-weight control group (C), coconut fat-treated normal weight group (CO), fish oil-treated normal weight group (FO), obese control group (Ob), coconut fat-treated obese group (ObCO) and fish oil-treated obese group (ObFO). Obese insulin-resistant rats were supplemented with fish oil or coconut fat (1 g/kg/day) for 4 weeks. Insulin sensitivity, fasting blood biochemicals parameters, and skeletal muscle glucose metabolism were analyzed. RESULTS: Obese animals (Ob) presented higher Index Lee and 2.5 fold epididymal and retroperitoneal adipose tissue than C. Insulin sensitivity test (Kitt) showed that fish oil supplementation was able to maintain insulin sensitivity of obese rats (ObFO) similar to C. There were no changes in glucose and HDL-cholesterol levels amongst groups. Yet, ObFO revealed lower levels of total cholesterol (TC; 30%) and triacylglycerol (TG; 33%) compared to Ob. Finally, since exposed to insulin, ObFO skeletal muscle revealed an increase of 10% in lactate production, 38% in glycogen synthesis and 39% in oxidation of glucose compared to Ob. CONCLUSIONS: Low dose of fish oil supplementation (1 g/kg/day) was able to reduce TC and TG levels, in addition to improved systemic and muscle insulin sensitivity. These results lend credence to the benefits of n-3 fatty acids upon the deleterious effects of insulin resistance mechanisms.
Asunto(s)
Conducta Alimentaria/efectos de los fármacos , Aceites de Pescado/administración & dosificación , Aceites de Pescado/farmacología , Resistencia a la Insulina , Insulina/metabolismo , Lípidos/sangre , Obesidad/metabolismo , Animales , Dieta , Ácidos Grasos/análisis , Insulina/sangre , Masculino , Músculo Esquelético/metabolismo , Obesidad/sangre , Ratas , Ratas Wistar , Glutamato de Sodio/administración & dosificaciónRESUMEN
Many studies have shown that addition of fish oil (FO) to the diet reduces tumor growth but the mechanism(s) of action involved is (are) still unknown. In this study, we examine some possible mechanisms in tumor-bearing rats chronically supplemented with FO. Male Wistar rats (21 days old) were fed with regular chow and supplemented with coconut or FO (1g/kg body weight) until they reached 70 days of age. Then, they were inoculated with a suspension of Walker 256 ascitic tumor cells (2 x 10(7)ml) and after 14 days they were killed. Supplementation with FO resulted in significantly lower tumor weight, greater tumor cell apoptosis, lower ex vivo tumor cell proliferation, a higher tumor content of lipid peroxides, lower expression of cyclooxygenase-2 (COX-2) in tumor tissue and a lower plasma concentration of prostaglandin E2 than observed in rats fed regular chow or supplemented with coconut oil. These results suggest that reduction of tumor growth by FO involves an increase in apoptosis and of lipid peroxidation in tumor tissue, with a reduction in tumor cell proliferation ex vivo, COX-2 expression and PGE2 production. Thus, FO may act simultaneously through multiple effects to reduce tumor growth. Whether these effects are connected through a single underlying mechanism remains to be seen.