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Métodos Terapéuticos y Terapias MTCI
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1.
Phytother Res ; 17(6): 688-90, 2003 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-12820243

RESUMEN

The strongly basic alkaloidal fraction of the traditional medicinal plant Rhazya stricta (RS) was given orally to mice, in a single dose of 10 mg/kg (group 1) or, twice daily for 3 days at the same dose (group 2). A third group (control) received normal saline. Liver homogenates from all animals were used to assess the microsomal activity of cytochrome P450 and its isoforms as well as its catalytic activity (using theophylline as a substrate). RS alkaloidal fraction had no significant effect on the total amount of microsomal cytochrome P450, but it caused a significant increase in the cytochrome P450 isoforms CYPs 1A1 and 1A2. It also significantly increased the concentrations of some metabolites of theophylline. These results suggest that RS has the potential to interact with other drugs that are biotransformed by cytochrome P450, when given concomitantly with it.


Asunto(s)
Apocynaceae , Sistema Enzimático del Citocromo P-450/metabolismo , Microsomas Hepáticos/efectos de los fármacos , Fitoterapia , Extractos Vegetales/farmacología , Teofilina/farmacocinética , Administración Oral , Animales , Interacciones Farmacológicas , Masculino , Ratones , Microsomas Hepáticos/metabolismo
2.
Phytomedicine ; 9(6): 501-7, 2002 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-12403158

RESUMEN

The analgesic activity of the methanol and acetone extracts of Leucas inflata L. (family Labiatae) was evaluated in mice using different experimental models. The effect of the two extracts on pentobarbitone-sleeping time, motor activity, sensorimotor coordination, carrageen induced inflammation, and brewer's yeast-induced pyrexia has also been investigated. The two crude extracts have been phytochemically analyzed and some constituents isolated and characterized. These included stigmasterols, a chromone and coumarins. Extracts of L. inflata L., given at single oral doses of 0.25, 0.5, 1.0 or 2.0 g/kg, significantly and dose-dependently, reduced formalin-induced pain, acetic acid induced abdominal constrictions and increased the reaction time in the hot-plate test. Both extracts caused significant and dose-related impairment in the sensorimotor control and ambulatory and total motor activity of treated mice. Both extracts exhibited anti-inflammatory action by reducing paw edema of treated mice. The extracts did not significantly affect the rectal temperature of normothermic mice. However, they were effective in preventing Brewers yeast induced pyrexia. It is concluded that the crude methanol and acetone extract of L. inflata has CNS depressant properties, manifested as antinociception and sedation. Both extracts have anti-inflammatory and antipyretic actions.


Asunto(s)
Fármacos del Sistema Nervioso Central/farmacología , Lamiaceae , Extractos Vegetales/farmacología , Analgésicos/farmacología , Analgésicos/uso terapéutico , Analgésicos no Narcóticos/farmacología , Analgésicos no Narcóticos/uso terapéutico , Animales , Antiinflamatorios no Esteroideos/farmacología , Antiinflamatorios no Esteroideos/uso terapéutico , Temperatura Corporal/efectos de los fármacos , Carragenina/administración & dosificación , Fármacos del Sistema Nervioso Central/uso terapéutico , Cumarinas/farmacología , Cumarinas/uso terapéutico , Relación Dosis-Respuesta a Droga , Edema/inducido químicamente , Edema/tratamiento farmacológico , Inflamación/inducido químicamente , Inflamación/tratamiento farmacológico , Masculino , Ratones , Actividad Motora/efectos de los fármacos , Fitoterapia , Extractos Vegetales/uso terapéutico , Desempeño Psicomotor/efectos de los fármacos , Estigmasterol/farmacología , Estigmasterol/uso terapéutico , Pruebas de Toxicidad Aguda
3.
J Ethnopharmacol ; 81(1): 121-7, 2002 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-12020936

RESUMEN

Salvia aegyptiaca L. is used for treating various unrelated conditions that include nervous disorders, dizziness, trembling, diarrhoea and piles. This work examines some effects of the crude acetone and methanol extracts of the plant given at single oral doses of 0.25, 0.5, 1 or 2 g/kg, on the central nervous system (CNS) in mice. The extracts were also tested for anti-inflammatory and antipyretic actions. Several models of nociception have been used to examine the analgesic effect of the extract. In treated mice, the extracts caused dose-related inhibition of acetic acid-induced abdominal constriction, and significantly reduced formalin-induced pain. Treatment with the extracts at doses of 0.5 and 1 g/kg significantly increased the reaction time in the hot-plate test. In treated mice both extracts caused significant and dose-related impairment of the sensorimotor control and motor activity. Treatment with both extracts did not significantly affect the rectal temperature of normothermic mice. The methanol extract (0.5 and 1.0 g/kg) did not affect the rectal temperature of hyperthermic mice, but the acetone extract was effective in significantly reducing the rectal temperature of hyperthermic mice, 0.5 and 1 h after administration of the extract at doses of 0.25-2 g/kg. It is concluded that the crude methanol and acetone extracts of S. aegyptiaca have CNS depressant properties, manifested as antinociception and sedation. Both extracts have some anti-inflammatory and antipyretic actions. On the whole, the acetone extract appeared to be slightly more effective than the methanol extract in this regard.


Asunto(s)
Sistema Nervioso Central/efectos de los fármacos , Extractos Vegetales/farmacología , Salvia/química , Acetona , Analgésicos no Narcóticos/administración & dosificación , Analgésicos no Narcóticos/farmacología , Analgésicos no Narcóticos/uso terapéutico , Animales , Antiinflamatorios/administración & dosificación , Antiinflamatorios/farmacología , Antiinflamatorios/uso terapéutico , Temperatura Corporal/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Masculino , Metanol , Ratones , Actividad Motora/efectos de los fármacos , Dolor/inducido químicamente , Dolor/tratamiento farmacológico , Fitoterapia , Extractos Vegetales/administración & dosificación , Extractos Vegetales/uso terapéutico , Desempeño Psicomotor/efectos de los fármacos
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