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Métodos Terapéuticos y Terapias MTCI
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1.
Clin Nutr ; 36(3): 672-679, 2017 06.
Artículo en Inglés | MEDLINE | ID: mdl-27406859

RESUMEN

BACKGROUND & AIMS: The effect of lycopene-containing foods in prostate cancer development remains undetermined. We tested whether a lycopene-rich tomato intervention could reduce the levels of prostate specific antigen (PSA) in prostate cancer patients. METHODS: Prior to their curative treatment, 79 patients with prostate cancer were randomized to a nutritional intervention with either 1) tomato products containing 30 mg lycopene per day; 2) tomato products plus selenium, omega-3 fatty acids, soy isoflavones, grape/pomegranate juice, and green/black tea (tomato-plus); or 3) control diet for 3 weeks. RESULTS: The main analysis, which included patients in all risk categories, did not reveal differences in changes of PSA-values between the intervention and control groups. Post-hoc, exploratory analyses within intermediate risk (n = 41) patients based on tumor classification and Gleason score post-surgery, revealed that median PSA decreased significantly in the tomato group as compared to controls (-2.9% and +6.5% respectively, p = 0.016). In separate post-hoc analyses, we observed that median PSA-values decreased by 1% in patients with the highest increases in plasma lycopene, selenium and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium and C20:5 n-3 fatty acid (p = 0.003). Also, PSA decreased in patients with the highest increase in lycopene alone (p = 0.009). CONCLUSIONS: Three week nutritional interventions with tomato-products alone or in combination with selenium and n-3 fatty acids lower PSA in patients with non-metastatic prostate cancer. Our observation suggests that the effect may depend on both aggressiveness of the disease and the blood levels of lycopene, selenium and omega-3 fatty acids.


Asunto(s)
Carotenoides/administración & dosificación , Antígeno Prostático Específico/sangre , Neoplasias de la Próstata/sangre , Neoplasias de la Próstata/dietoterapia , Solanum lycopersicum/química , Anciano , Carotenoides/sangre , Dieta , Ácidos Grasos Omega-3/administración & dosificación , Ácidos Grasos Omega-3/sangre , Jugos de Frutas y Vegetales , Humanos , Isoflavonas/administración & dosificación , Licopeno , Lythraceae/química , Masculino , Persona de Mediana Edad , Selenio/administración & dosificación , Selenio/sangre , Glycine max/química , Vitis/química
2.
Nutr Cancer ; 63(6): 889-98, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21714686

RESUMEN

We conducted a placebo-controlled, block-randomized double-blind Phase 2 study to examine the effect of 30 mg synthetic genistein daily on serum and tissue biomarkers in patients with localized prostate cancer (CaP). Fifty-four study subjects were recruited and randomized to treatment with genistein (n = 23) or placebo (n = 24) for 3 to 6 wk prior to prostatectomy. Seven study subjects were noncompliant to the study protocol. Adverse events were few and mild. Serum prostate specific antigen (PSA) decreased by 7.8% in the genistein arm and increased by 4.4% in the placebo arm (P = 0.051). The PSA level was reduced in tumor tissue compared to normal tissue in the placebo arm. In the genistein arm, the PSA level in tumor and normal tissue was comparable. Total cholesterol was significantly lower in the genistein arm (P = 0.013). There were no significant effects on thyroid or sex hormones. Plasma concentrations of total genistein were on average 100-fold higher in the genistein arm after treatment (P < 0.001). Genistein at a dose that can be easily obtained from a diet rich in soy reduced the level of serum PSA in patients with localized CaP, without any effects on hormones. It was well tolerated and had a beneficial effect on blood cholesterol.


Asunto(s)
Genisteína/uso terapéutico , Fitoterapia , Extractos Vegetales/uso terapéutico , Prostatectomía , Neoplasias de la Próstata/tratamiento farmacológico , Biomarcadores/sangre , HDL-Colesterol/sangre , LDL-Colesterol/sangre , Dieta , Método Doble Ciego , Determinación de Punto Final , Genisteína/sangre , Humanos , Inmunohistoquímica , Masculino , Persona de Mediana Edad , Neoplasias de la Próstata/cirugía , Glycine max/química , Tirotropina/sangre
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