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BMJ Case Rep ; 20162016 Jan 28.
Artículo en Inglés | MEDLINE | ID: mdl-26823359

RESUMEN

We present a case series of three patients with sodium valproate-induced Fanconi's syndrome, with ages ranging from 5 years to 12 years. The most important diagnostic features of this syndrome include hypophosphataemia, glycosuria and proteinuria, which are also noted in our series. Furthermore, also added is that clinical fractures representing an underlying osteopaenia may provide an opportunity for early intervention as it raises the suspicion of Fanconi's syndrome. Previous case reports suggest there is a subpopulation of individuals who are at risk of developing this condition. These individuals share similar characteristics, including being non-ambulatory, developmentally delayed and/or tube fed. Withdrawing sodium valproate therapy is the ultimate treatment for valproate-induced Fanconi's syndrome and from previous case series, normalised renal function occurs in approximately 6 months. Often, supplement support is also required for deranged electrolyte balance.


Asunto(s)
Anticonvulsivantes/efectos adversos , Síndrome de Fanconi/inducido químicamente , Ácido Valproico/efectos adversos , Acidosis Tubular Renal/diagnóstico , Niño , Preescolar , Diagnóstico Diferencial , Síndrome de Fanconi/diagnóstico , Humanos , Masculino , Convulsiones/tratamiento farmacológico
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