Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros

Bases de datos
País/Región como asunto
Tipo del documento
Intervalo de año de publicación
1.
Int J Antimicrob Agents ; 54(5): 633-641, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31202921

RESUMEN

Ceftazidime/avibactam (CAZ-AVI) is a novel, fixed-dose combination antibiotic that has been approved in Europe and the United States for patients with complicated urinary tract infections (cUTIs) based on results of a Phase III, randomized, comparative study (RECAPTURE study). The present analysis evaluated cost-effectiveness of CAZ-AVI as an empirical treatment for hospitalized patients with cUTIs from the Italian publicly funded healthcare (third-party payer) perspective. A sequential, patient-level simulation model was developed that followed the clinical course of cUTI and generated 5000 pairs of identical patients (CAZ-AVI or imipenem as empirical treatment). The model included additional impact of resistant pathogens; patients who did not respond to empirical treatment were switched to second-line treatment of colistin+high dose carbapenem in both groups. The time horizon of the model was five years, with an annual discount rate of 3% applied to both costs and quality-adjusted life-years (QALYs). The analysis demonstrated that an intervention sequence (CAZ-AVI followed by colistin+high dose carbapenem) compared with a comparator sequence (imipenem followed by colistin+high dose carbapenem) was associated with a net incremental cost of €1015 per patient but provided better health outcomes in terms of clinical cure (97.65% vs. 91.08%; ∆ = 6.57%), shorter hospital stays (10.65 vs. 12.55 days; ∆ = 1.90 days), and QALYs gained per patient (4.190 vs. 4.063; ∆ = 0.126). The incremental cost-effectiveness ratio was €8039/QALY, which is well below the willingness-to-pay threshold of €30 000/QALY in Italy. The results showed that CAZ-AVI is expected to be a cost-effective treatment compared with imipenem for cUTI in Italy.


Asunto(s)
Antibacterianos/economía , Compuestos de Azabiciclo/economía , Ceftazidima/economía , Análisis Costo-Beneficio/métodos , Imipenem/economía , Tiempo de Internación/economía , Infecciones Urinarias/tratamiento farmacológico , Antibacterianos/uso terapéutico , Compuestos de Azabiciclo/uso terapéutico , Carbapenémicos/economía , Carbapenémicos/uso terapéutico , Ceftazidima/uso terapéutico , Colistina/economía , Colistina/uso terapéutico , Combinación de Medicamentos , Europa (Continente) , Bacterias Gramnegativas/efectos de los fármacos , Humanos , Imipenem/uso terapéutico , Programas Nacionales de Salud , Estados Unidos , Infecciones Urinarias/microbiología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA