[The action of an enzymatically stable Leu-enkephalin analog on the prostanoid content in the myocardium under stress- and adrenaline-induced damage]. / Vozdeistvie énzimoustoichivogo analoga lei-énkefalina na soderzhanie prostanoidov v miokarde pri stressornom i adrenalinom povrezhdenii.

The protective action of enzymatically stable analogue of Leu-enkephalin (D-ala-2-leu5-arg6), injected intraperitoneally, in the course of stress- and epinephrine induced myocardial damage was demonstrated in animal (129 white rats) experiments. Two effect of enkephalin were sufficient for the cardiac protection: enkephalin-stimulated prostacyclin biosynthesis and simultaneous inhibition of thromboxane production.

[Phenotypic correction of the immune response by L-tyrosine in mice reacting oppositely to sheep erythrocytes]. / Fenotipicheskaia korrektsiia immunnogo otveta L-tirozinom u myshei, oppozitno reagiruiushchikh na éritrotsity barana.

The possibility of transversion of low-reacting mice into high-reacting ones evaluated by the application of the natural immunostimulators. L-tyrosine and thymic polypeptides (taktivin) were compared by their ability for the phenotypical correction of the immune response of the oppositely reacting mice. It was established that under the application of L-tyrosine to oppositely reacting mice the phenotypical correction of the immune response is possible. The dramatic increase in AFC and the AFC-SI secreting IgM is observed in the mice, low-reacting to SRBC in comparison with the high-reacting lines.

[Comparative evaluation of the effect of kontrikal, 5-fluorouracil and the new Soviet peptide preparation dalargin on the course of experimental pancreonecrosis]. / Sravnitel'naia otsenka vliianiia kontrikala, 5-ftoruratsila i novogo otechestvennogo peptidnogo preparata dalargina na techenie éksperimental'nogo pankreonekroza.

The experiments on 24 dogs with experimental hemorrhagic pancreonecrosis showed that contrykal and 5-fluorouracil insignificantly decrease the area of the damaged parenchyma, fail to cease progression of the pancreas destruction. The peptide drug dalargin in these conditions increased the antitryptic activity and normalized BAEE esterase activity. Dalargin abolished erythrostasis and microthromboses in the vessels of the microcirculation, restored the blood supply throughout the area of the exocrine parenchyma, limited necrotic foci and suspended the development of pancreonecrosis.

[Dalargin--a peptide preparation with cytoprotective action]. / Dalargin--a peptidnyi preparat s tsitoprotektivnym deistviem.

The role and possible clinical use of regulatory peptides, a new type of regulatory substances, is discussed. Special attention is paid to the opioid peptides and their analogues. The new drug dalargin has been developed on the basis of the endogenous opioid peptide leucine-encephalin. Its action has been studied using experimental models. It has been established that the optimal dose (10 micrograms/kg) of dalargin is effective in preventing ulceration in the cystamine duodenal ulcer rat model and the development of stomach erosive lesions in immobilization stress, reducing the degree of liver degeneration in CCl4 poisoning, etc. With an increase of the dose of dalargin the effect "escapes". Dalargin is primarily bound by delta-receptors, it produces no analgetic effect and does not enter the brain. Dalargin exhibits a pronounced cytoprotective and regeneratory action and may take an important place in treating the internal organ diseases.

[Effect of met- and leu-enkephalins and their synthetic analog on stimulation and acupunture analgesia]. / Vliianie met- i lei-énkefalinov i ikh sinteticheskogo analoga na stimuliatsionnuiu i akupunkturnuiu anal'geziiu.

Experiments on unrestrained rats were carried out to study the effect of intraventricularly injected met- and leu-enkephalins and their synthetic analog Tyr-dAla-Cly-Phe-NH2 on analgesia induced by electrical stimulation of the central gray. It was shown that subanalgesic doses of enkephalins and their synthetic analog facilitated the appearance of analgesic action on subthreshold antinociceptive-brain stimulation and potentiated the analgesic effect of threshold central gray stimulation. Subanalgesic and low analgesic doses of the peptides increased antinociceptive effect of electroacupuncture. The data obtained are discussed from the standpoint of the implication of the peptidergic mechanisms in the realization of acupuncture and stimulation analgesia.

[Effect of enkephalins on central processes regulating hemodynamics]. / Vliianie énkefalinov na protsessy tsentral'noi reguliatsii gemodinamiki.

Intracisternal administration of leu- or met-enkephalins in a dose of 100 micrograms into unanesthetized cats evoked a short-lasting elevation of arterial pressure and tachycardia. After 1.5-2 minutes the blood pressure returned to normal and bradycardia developed (heart rate = 86 +/- 3.4% of initial). Alterations in the arterial pressure and heart rate were prevented by naloxon in a dose of 50-100 micrograms administered into the 4th ventricle. Leu-enkephalin inhibited the sensitivity of the baroreceptor reflex and increased by 69% the pressor reactions evoked by hypothalamus stimulation. Met-enkephalin was half as potent with respect to the baroreceptor reflex and exerted no effect on the hemodynamic reactions evoked by hypothalamus stimulation.