RESUMEN
BACKGROUND/PURPOSE: Isoflavones, one main group of phytoestrogens, have antioxidative and photoprotective effects in cellular and mouse studies. The aim of this study is to obtain a more comprehensive understanding of the isoflavone-mediated photoprotection with the pig skin model, a more human-resembling model. METHODS: The pig skin was treated with five well-known isoflavone compounds (genistein, equol, daidzein, biochanin A, and formononetin) and one antioxidant combination solution of 15% vitamin C and 1% vitamin E and 0.5% ferulic acid (CEF) daily for 4 days. Skin was irradiated with solar-simulated UV irradiation, 1 to 5 minimal erythema dose (MED) at 1-MED intervals. Evaluation was carried out 24 h later by colorimeter-measured erythema and sunburn cell numbers. RESULTS: Topical application of 0.5% solutions of three individual phytoestrogens - genistein, daidzein, biochanin A - are better than similar solutions of equol or formononetin in protecting pig skin from solar-simulated ultraviolet (SSUV)-induced photodamage, as measured by sunburn cell formation and/or erythema. However, the protection was less than that provided by a topical combination antioxidant standard containing 15% L-ascorbic acid, 1%alpha-tocopherol, and 0.5% ferulic acid. CONCLUSION: Isoflavones provide effective photoprotection and are good candidate ingredients for protection against ultraviolet (UV) photodamage.
Asunto(s)
Isoflavonas/farmacología , Fitoterapia , Plantas Medicinales , Piel/efectos de los fármacos , Quemadura Solar/prevención & control , Protectores Solares/farmacología , Administración Cutánea , Animales , Ácido Ascórbico/administración & dosificación , Ácido Ascórbico/farmacología , Ácido Ascórbico/uso terapéutico , Ácidos Cumáricos/administración & dosificación , Ácidos Cumáricos/farmacología , Ácidos Cumáricos/uso terapéutico , Relación Dosis-Respuesta a Droga , Combinación de Medicamentos , Equol , Genisteína/administración & dosificación , Genisteína/farmacología , Genisteína/uso terapéutico , Isoflavonas/administración & dosificación , Isoflavonas/uso terapéutico , Piel/efectos de la radiación , Quemadura Solar/patología , Luz Solar/efectos adversos , Protectores Solares/administración & dosificación , Protectores Solares/uso terapéutico , Porcinos , Vitamina E/administración & dosificación , Vitamina E/farmacología , Vitamina E/uso terapéuticoRESUMEN
BACKGROUND AND OBJECTIVES: There are many treatment modalities for psoriasis including topical therapy, ultraviolet light therapy, systemic agents, and more recently the advent of the biologic agents. STUDY DESIGN/MATERIALS AND METHODS: In addition, selective treatment using lasers and light sources that target the individual psoriatic plaques have also been employed. RESULTS/CONCLUSION: This article will highlight and review the employment of laser-assisted devices in the treatment of plaque psoriasis.