RESUMEN
The major non-azadirachtin limonoids such as gedunin (1), epoxyazadiradione (3), nimbocinol (4), and nimolicinol (5) from Azadirachta indica A. Juss ('neem') and their derivatives were evaluated for their toxic action against fourth instar larvae of Aedes aegypti L. and Culex quinquefasciatus Say. Gedunin exhibited 100% toxic action against both the mosquito larvae at 50 and 10 ppm. Epoxyazadiradione and epoxynimolicinol also showed significant toxicities (> or =50%) against larvae of both mosquito species at 50 ppm. These neem limonoids can have benefits in mosquito-control programs.
Asunto(s)
Aedes/efectos de los fármacos , Culex/efectos de los fármacos , Insecticidas/química , Limoninas/química , Animales , Azadirachta/química , Insecticidas/aislamiento & purificación , Insecticidas/toxicidad , Larva/efectos de los fármacos , Limoninas/aislamiento & purificación , Limoninas/toxicidad , Extractos Vegetales/química , Semillas/química , Relación Estructura-ActividadRESUMEN
The larvicidal activities of various fractions of the hexane extract of the seeds of Sterculia guttata against larvae of Aedes aegypti and Culex quinquefasciatus were determined. Bis(2-ethylhexyl) benzene-1,2-dicarboxylate (1) was identified as one of the active principles, displaying chronic toxicity against both types of larvae, with LD50 values of 79 and 64 ppm, respectively.
Asunto(s)
Aedes/efectos de los fármacos , Benceno/farmacología , Culex/efectos de los fármacos , Ácidos Dicarboxílicos/farmacología , Insecticidas/farmacología , Semillas , Sterculia , Aedes/fisiología , Animales , Benceno/química , Benceno/aislamiento & purificación , Culex/fisiología , Culicidae , Ácidos Dicarboxílicos/química , Ácidos Dicarboxílicos/aislamiento & purificación , Insecticidas/química , Insecticidas/aislamiento & purificación , Larva/efectos de los fármacos , Larva/fisiología , Control de Mosquitos/métodos , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/farmacología , Especificidad de la EspecieRESUMEN
Extracts and purified extracts of seeds of two plant species, Madhuca latifolia and Calophyllum inophyllum when evaluated against the 2nd instar larvae of Helicoverpa armigera reared on synthetic diet, exhibited high larval mortality, prolongation of developmental period, morphological deformities and highly significant reduction in adult emergence. The reduction in larval weights in the treatments was also highly significant.