RESUMEN
1-[(3-chlorophenyl)phenylmethyl]urea--a compound possessing anticonvulsant activity, which has been selected by screening among 100 linear and cyclic urea derivatives, produces synchronization of spontaneous bioelectric activity, increased convulsion threshold in the motor cortex, dorsal hippocampus, and basolateral nuclei of amygdala, increased the index of low-frequency flicker acquisition, and reduced response to high-frequency oscillations in the visual cortex of rabbits. This compound also increased the extracellular content of sodium ions and reduced intracellular content of potassium ions in the motor cortex, dorsal hippocampus, and amygdala.
Asunto(s)
Anticonvulsivantes/farmacología , Potenciales Evocados Motores/efectos de los fármacos , Potenciales Evocados Visuales/efectos de los fármacos , Convulsiones/prevención & control , Urea/análogos & derivados , Animales , Complejo Nuclear Basolateral/efectos de los fármacos , Complejo Nuclear Basolateral/metabolismo , Complejo Nuclear Basolateral/fisiopatología , Cationes Monovalentes , Estimulación Eléctrica , Femenino , Hipocampo/efectos de los fármacos , Hipocampo/metabolismo , Hipocampo/fisiopatología , Transporte Iónico/efectos de los fármacos , Masculino , Microelectrodos , Corteza Motora/efectos de los fármacos , Corteza Motora/metabolismo , Corteza Motora/fisiopatología , Estimulación Luminosa , Potasio/metabolismo , Conejos , Convulsiones/metabolismo , Convulsiones/fisiopatología , Sodio/metabolismo , Técnicas Estereotáxicas , Urea/farmacología , Corteza Visual/efectos de los fármacos , Corteza Visual/metabolismo , Corteza Visual/fisiopatologíaRESUMEN
The effects of ethomersole (50 mg/kg orally during 10 days) on local cerebral blood flow and cerebral tissue impedance were investigated in rats after left carotid artery ligation and right carotid artery narrowing (blood flow was decreased to 50%). Under these conditions, ethomersole accelerated the blood flow recovery, levelled blood flow asymmetry between the hemispheres, decreased the development of brain edema. In in vitro experiments ethomersole demonstrated a pronounced limitation of cerebral lipid peroxidation.