RESUMEN
Five young adult pet marmosets (Callithrix spp.) were presented with weight loss (5/5); fecal retention (3/5); diarrhea (2/5); impaired locomotion (3/5); anemia (4/4); hypoproteinemia or hypoalbuminemia (3/4); elevations of creatine phosphokinase, lactic dehydrogenase, and alanine aminotransferase (3/4); and renal failure with hypercholesterolemia (2/4). All anemic marmosets had low serum vitamin E levels. The anemia responded to vitamin E and selenium therapy in two marmosets. One of the five marmosets died before presentation, and two others died despite therapy. The two marmosets necropsied had degenerative myopathy, pyogranulomatous pansteatitis, and increased erythrophagocytosis and hemosiderosis. The striated muscle and adipose tissue of both marmosets were negative for coxsackievirus ribonucleic acid by in situ hybridization. These findings suggest that vitamin E deficiency may be involved in the development of anemia, myopathy, and steatitis in callitrichids; however, in some marmosets, underlying diseases such as chronic colitis may have influenced the development of anemia and impaired vitamin E status.
Asunto(s)
Anemia/veterinaria , Callithrix , Enfermedades de los Monos/patología , Enfermedades Musculares/veterinaria , Esteatitis/patología , Deficiencia de Vitamina E/veterinaria , Tejido Adiposo/patología , Anemia/complicaciones , Anemia/dietoterapia , Anemia/patología , Animales , Enterovirus/genética , Enterovirus/crecimiento & desarrollo , Femenino , Histocitoquímica/veterinaria , Hibridación in Situ/veterinaria , Masculino , Enfermedades de los Monos/dietoterapia , Músculo Esquelético/patología , Enfermedades Musculares/complicaciones , Enfermedades Musculares/dietoterapia , Enfermedades Musculares/patología , ARN Viral/química , ARN Viral/genética , Selenio/uso terapéutico , Esteatitis/dietoterapia , Esteatitis/metabolismo , Vitamina E/uso terapéutico , Deficiencia de Vitamina E/complicaciones , Deficiencia de Vitamina E/dietoterapia , Deficiencia de Vitamina E/patologíaRESUMEN
A squirrel monkey (Saimiri sciureus) presented with wasting, vomiting and diarrhoea. Haematology revealed elevation of creatinine phosphokinase, lactic dehydrogenase, alanine aminotransferase, amylase and lipase, together with azotaemia and hypoalbuminaemia. Prominent findings were chronic pancreatitis with acinar and ductal plugs, granulomatous and necrotizing peripancreatic steatitis, degenerative myopathy, testicular atrophy, candidiasis and bacterial necrotizing glossitis. Antioxidant analyses revealed low concentrations of serum vitamin E (and apparently A), hepatic selenium and hair zinc. Pancreatitis may have caused malabsorption and maldigestion, associated with deficiency of multiple antioxidants.