RESUMEN
A phytochemical investigation of the rhizomes of Curcuma zedoaria was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (1), together with four known compounds (2-5). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed α-glucosidase inhibitory activity, with the IC50 values ranging from 35.2 to 89.0 µM, more potent than that of the positive control acarbose (IC50, 214.5 µM).
Asunto(s)
Curcuma , Sesquiterpenos , Curcuma/química , Extractos Vegetales/química , Rizoma/química , Sesquiterpenos/químicaRESUMEN
From an ethyl acetate-soluble fraction of the leaves of Muntingia calabura, one new trimeric δ-tocopherol derivative named as tocomuntin A (1), together with three known δ-tocopherol derivatives (2-4) were isolated. Their structures were elucidated based on the interpretation of NMR and MS spectroscopic data. In this work, δ-tocopherol (3) was found to have α-glucosidase inhibitory activity for the first time (IC50, 47.3 µM).
Asunto(s)
Magnoliopsida , Extractos Vegetales , Hojas de la Planta , Tocoferoles , Extractos Vegetales/química , Hojas de la Planta/química , Magnoliopsida/química , Tocoferoles/química , Inhibidores de Glicósido Hidrolasas/químicaRESUMEN
From the methanol extract of the wood of Mangifera gedebe (Anacardiaceae), we had isolated a new secondary metabolite named gedebic acid (1) and six known compounds (2-7). Their chemical structures were determined by spectroscopic methods as well as comparing with data in the literature. All compounds were tested for α-glucosidase inhibitory activity. Compounds 4-7 showed more potent inhibitory activity, with IC50 values ranging from 45.3 to 142.6 µM, than that of a positive control acarbose (IC50, 214.5 µM).