RESUMEN
The microcapsules with entrapped herbal water-soluble extracts Plantago major and Calendula officinalis L. (HE) were prepared by LbL-adsorption of carrageenan and modificated chitosan onto CaCO3 microparticles with their subsequent dissolving after the treatment of EDTA. Entrapment of HE was performed by adsorption and co-precipitation techniques. The co-precipitation provided better entrapment of HE compared to adsorption. In vitro release kinetics in an artificial gastric juice (AGJ) was studied. The HE release was shown to accelerate gastric ulcer treatment in a rat model.
Asunto(s)
Calendula , Cápsulas/farmacología , Extractos Vegetales/farmacología , Plantago , Úlcera Gástrica/tratamiento farmacológico , Adsorción , Animales , Carbonato de Calcio/química , Calendula/química , Cápsulas/química , Cápsulas/farmacocinética , Carragenina/química , Carragenina/farmacocinética , Carragenina/farmacología , Quitosano/química , Quitosano/farmacocinética , Quitosano/farmacología , Modelos Animales de Enfermedad , Ácido Edético/química , Jugo Gástrico/química , Masculino , Extractos Vegetales/química , Extractos Vegetales/farmacocinética , Plantago/química , RatasRESUMEN
Wistar rats have been exposed to X-rays with a dose of 5 Gy. Significant decrease in dehydrogenase activity, energy-rich phosphate level and efficiency of antioxidant defence and significant increase in pyruvate amount were observed within 4 weeks. It was also found that the feeding of exposed rats with phycocyanin extract from blue-green algae Spirulina platensis lead to correcting effect. The same result was observed after injections of tocopherol or complex of six water-soluble vitamins. The combination of above mentioned compounds had more marked effect, especially at the presence unitiole and Na2Se.