Asunto(s)
Antitrombinas/efectos adversos , Bencimidazoles/efectos adversos , Monitoreo de Drogas/métodos , Trastornos Hemorrágicos/inducido químicamente , Piridinas/efectos adversos , Tromboelastografía , Antitrombinas/sangre , Antitrombinas/farmacología , Bencimidazoles/sangre , Bencimidazoles/farmacología , Coagulación Sanguínea/efectos de los fármacos , Factores de Coagulación Sanguínea/farmacología , Dabigatrán , Evaluación Preclínica de Medicamentos , Factor VIIa/farmacología , Fibrina/biosíntesis , Trastornos Hemorrágicos/sangre , Humanos , Técnicas In Vitro , Sistemas de Atención de Punto , Piridinas/sangre , Piridinas/farmacología , Proteínas Recombinantes/farmacología , Trombina/antagonistas & inhibidores , Tiempo de Coagulación de la Sangre TotalRESUMEN
OBJECTIVE: This case study reports on selected measures of locomotion (running) in a 5-year-old patient with xeroderma pigmentosum after chiropractic care. CLINICAL FEATURE: A 5-year-old female patient (16.4 kg, 99.1 cm) with xeroderma pigmentosum (type A) volunteered to participate in the experiment with the consent of her parents. The patient had well-documented signs of delayed fine motor (eg, difficulty with writing, coloring, cutting) and gross motor control (eg, balance and coordination dysfunction and falling while running), and delayed speech. INTERVENTION AND OUTCOMES: Trunk forward lean angles, step lengths, and hip horizontal translations were assessed by video as the participant ran as fast as possible down a laboratory runway. After chiropractic manipulation (adjustments), the patient reduced the trunk forward lean angle to become more vertical (P = .000). In addition, the patient experienced an increase in step length (P = .031). No significant change in lateral translation was observed after the intervention. CONCLUSION: For this patient with xeroderma pigmentosum, chiropractic manipulation (adjustments) resulted in immediate changes in running performance. Further investigation is needed to examine the effect of chiropractic on locomotion in both symptomatic and asymptomatic patients.
Asunto(s)
Marcha/fisiología , Manipulación Quiropráctica , Carrera/fisiología , Xerodermia Pigmentosa/terapia , Preescolar , Femenino , Humanos , Trastornos de la Destreza Motora/etiología , Equilibrio Postural/fisiología , Trastornos del Habla/etiología , Xerodermia Pigmentosa/complicaciones , Xerodermia Pigmentosa/fisiopatologíaRESUMEN
In industrialized countries, over-the-counter dietary supplements have become popular in preventing and treating an expanding list of medical conditions. Although most commercially available supplements have not been rigorously tested for safety and efficacy, they have found an enlarging market because they are considered natural. Oral supplements containing green tea extract have been marketed as effective for weight loss and to prevent and cure some solid tumors. Although there is little scientific evidence of the effectiveness of green tea extracts to improve the quality of health of regular consumers, there is an increasing body of medical literature supporting the hypothesis that they can cause serious side effects. Our experience adds to previous reports of acute liver toxicity observed in individuals consuming supplements containing green tea extract. We highlight the importance of obtaining a detailed history of dietary supplement consumption when evaluating a patient presenting with acute liver dysfunction.