RESUMEN
OBJECTIVE: To isolate and elucidate the chemical constituents in the roots of Rabdosia japonica. METHOD: The constituents were extracted by ether and isolated by chromatography on silica gel and ODS. The structures were determined by IR, H NMR, 13C NMR and MS spectra respectively. RESULT: Four compounds were elucidated as glaucocalgxin A, oleanolic acid, ursolic acid and daucosterol. CONCLUSION: Oleanolic acid and daucosterol were isolated from this plant for the first time.
Asunto(s)
Medicamentos Herbarios Chinos/aislamiento & purificación , Isodon/química , Ácido Oleanólico/aislamiento & purificación , Plantas Medicinales/química , Diterpenos de Tipo Kaurano , Medicamentos Herbarios Chinos/química , Ácido Oleanólico/química , Raíces de Plantas/química , Sitoesteroles/química , Sitoesteroles/aislamiento & purificación , Triterpenos/química , Triterpenos/aislamiento & purificación , Ácido UrsólicoRESUMEN
Objective. To observe the improved effect of syndromes of blood stasis by taking Chinese medicine during bed-rest simulated weightlessness. Method. Ten subjects were randomly divided into two groups: Chinese medicine group and control group. Both of them were exposed to HDBR -6 degrees for a week. The Chinese medicine group took Chinese medicine during the bed rest, and the control group took sugar water. Result. Syndromes of blood stasis of Chinese medicine group had a significant relief. And some physiological parameters, such as blood pressure, pulse graph, and amount of urine, maintained the level of pre-bed rest. While the control group was more severe than the Chinese medicine group in syndromes of blood stasis. Conclusion. Chinese medicine can be a measure in preventing the effect of weightlessness.
Asunto(s)
Presión Sanguínea/efectos de los fármacos , Medicamentos Herbarios Chinos/farmacología , Orina/fisiología , Simulación de Ingravidez , Adolescente , Adulto , Medicina Aeroespacial , Reposo en Cama , Circulación Sanguínea , Inclinación de Cabeza , Humanos , Pulso Arterial , Medidas contra la IngravidezRESUMEN
Objective. To observe the counteracting effect of a Chinese herb-compound on "insufficiency of spleen qi" induced by simulated weightlessness. Methods. Animal and human experiment were carried out to the Chinese herb-compound (Dangshen, Baizhu, Fuling etc). Result. This compound protected the tail suspended rats from atrophy of spleen, thymus, soleus and gastrocnemius muscles, prevented excessive decrease of body weight effectively; at the same time it relieved the symptoms of the subjects greatly. Conclusion. It demonstrated that the compound decreased the "insufficiency of spleen qi" of both animals and human subjects.
Asunto(s)
Medicamentos Herbarios Chinos/farmacología , Qi , Bazo/efectos de los fármacos , Timo/efectos de los fármacos , Simulación de Ingravidez , Medicina Aeroespacial , Animales , Peso Corporal/efectos de los fármacos , Suspensión Trasera , Humanos , Músculo Esquelético/efectos de los fármacos , Músculo Esquelético/fisiología , Ratas , Ratas Wistar , Bazo/fisiología , Timo/fisiología , Medidas contra la IngravidezRESUMEN
Experiments were carried out on mice and the subjects irradiated for cancer therapy to evaluate the protective efficacy of a Chinese medicinal herb-compound (CMHC). The lethality and the degree of leucopenia caused by radiation in mice medicated with CMHC were significantly less in comparison with control mice (p less than 0.01 and p less than 0.001, respectively). CMHC significantly improved the WBC and the thrombocytes in irradiated workers (p less than 0.01 and p less than 0.001, respectively). The WBC count of 40 patients under radiotherapy while treated with CMHC recovered from 3450 +/- 77/c.mm to 5425 +/- 264/c.mm (p less than 0.001); whereas, in the control group, without any medication, the WBC count dropped significantly (p less than 0.001). Our results revealed the applicabilities of CMHC in protection against radiation damage in spaceflight and in other fields.