RESUMEN
A new compound, integracid (1), together with four known compounds were isolated from the dichloromethane (CH2Cl2) extract from Artemisia integrifolia L. The structures of compounds (1-5) were elucidated by spectroscopic methods, including ultraviolet, infrared (IR), high resolution-electrospray ionization-mass spectrometry (HR-ESI-MS) and extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) techniques, and by comparison with data reported in the references. Antibacterial activities of the compounds were evaluated against various bacteria.
Asunto(s)
Antiinfecciosos/química , Artemisia/química , Extractos Vegetales/química , Antiinfecciosos/farmacología , Bacillus cereus/efectos de los fármacos , Extractos Vegetales/farmacología , Staphylococcus aureus/efectos de los fármacos , Triterpenos/química , Triterpenos/farmacología , Yersinia enterocolitica/efectos de los fármacosRESUMEN
The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay. Two new flavone C-glycosides, named as Sacroroside A and B (Compounds 1 and 2) were isolated from the EtOAc crude extract of the aerial parts ofArtemisa sacrorum Ledeb. They showed significant analgesic effects. In conclusion, Compounds 1 and 2 are new natural products, which show significant analgesic effects in a dose-dependent manner.
Asunto(s)
Analgésicos/uso terapéutico , Artemisia/química , Disacáridos/uso terapéutico , Flavanonas/uso terapéutico , Flavonas/uso terapéutico , Dolor/tratamiento farmacológico , Fitoterapia , Extractos Vegetales/uso terapéutico , Analgésicos/química , Analgésicos/aislamiento & purificación , Analgésicos/farmacología , Animales , Disacáridos/química , Disacáridos/aislamiento & purificación , Disacáridos/farmacología , Flavanonas/química , Flavanonas/aislamiento & purificación , Flavanonas/farmacología , Flavonas/química , Flavonas/aislamiento & purificación , Flavonas/farmacología , Calor , Masculino , Estructura Molecular , Componentes Aéreos de las Plantas , Extractos Vegetales/química , Extractos Vegetales/farmacología , Presión , Ratas WistarRESUMEN
OBJECTIVE: To study the chemical constituents of the ethyl acetate extract from Panzeria alaschanica. METHODS: The chemical constituents of ethyl acetate extract from Panzeria alaschanica were isolated and purified by silica gel. Their structures were i- dentified by means of spectra. RESULTS: Nine compounds were obtained and identified as 7-Methoxy coumarin (1), Isorhamnetin (2), Caf- feic acid (3), 5-Hydroxy-7,3',4'-trimethoxyflavone (4), 5-Hydroxy-7,4'-dimethoxyflavone (5),Kaempferol (6), Isorhamnetin-3-O-ß-D- glucoside (7) Kaempferol-3-O-ß-D-glucoside (8), and Isorhamnetin-7-O-ß-D-glucuronyl-(1-->6)-O-α-L-rhamnoside (9). CONCLUSION: Compounds 1-4,6,7 and 9 are isolated from this plant for the first time.
Asunto(s)
Fitoquímicos/análisis , Extractos Vegetales/química , Plantas Medicinales/química , Glucósidos , Quempferoles , Monosacáridos , Quercetina/análogos & derivadosRESUMEN
AIM: To study the chemical constituents of Lomatogonium carinthiacum (Wulfen) Rchb. METHOD: The CHCl3-soluble fraction was separated by chromatography and the structures of the new compounds were elucidated by spectral experiments. RESULTS: Two new xanthones, 1, 8-dihydroxy-4, 5-dimethoxy-6, 7-methylenedioxyxanthone (1), 1, 4, 8-trimethoxyxanthone-6-O-ß-D-glucoronyl-(1â6)O-ß-D-glucoside (2) were isolated from the whole plant of Lomatogonium carinthiacum. CONCLUSION: Compounds 1 and 2 are new natural products.
Asunto(s)
Gentianaceae/química , Glucósidos/aislamiento & purificación , Extractos Vegetales/química , Xantonas/aislamiento & purificación , Glucósidos/química , Estructura Molecular , Xantonas/químicaRESUMEN
Two new lignans, syripinnalignans A and B (1 and 2), together with two known lignans, were isolated from the stem of Syringa pinnatifolia Hemsl. Var. alashanensis. The structures of 1 and 2 were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques.
Asunto(s)
Medicamentos Herbarios Chinos/aislamiento & purificación , Lignanos/aislamiento & purificación , Schisandra/química , Medicamentos Herbarios Chinos/química , Lignanos/química , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Tallos de la Planta/químicaRESUMEN
An investigation of the n-BuOH-soluble fraction from the aerial parts of Artemisia frigida has led to the isolation of two new flavonoid glycosides, named friginoside A and friginoside B. Their structures were characterized as 5,7-dihydroxy-3',4',5'-trimethoxy flavone 7-O-ß-d-glucuronide (1) and 5,7-dihydroxy-3',4',5'-trimethoxyflavone 7-O-ß-d-glucuronyl-(1 â 2)O-ß-d-glucuronide (2) on the basis of 1D and 2D NMR spectral analysis.