Tenacissoside H repressed the progression of glioblastoma by inhibiting the PI3K/Akt/mTOR signaling pathway.

Glioblastoma (GBM) is one of the most common intracranial primary malignancies with the highest mortality rate, and there is a lack of effective treatments. In this study, we examined the anti-GBM activity of Tenacissoside H (TH), an active component isolated from the traditional Chinese medicine Marsdenia tenacissima (Roxb.) Wight & Arn (MT), and investigated the potential mechanism. Firstly, we found that TH decreased the viability of GBM cells by inducing cell cycle arrest and apoptosis, and inhibited the migration of GBM cells. Furthermore, combined with the Gene Expression Omnibus database (GEO) and network pharmacology as well as molecular docking, TH was shown to inhibit GBM progression by directly regulating the PI3K/Akt/mTOR pathway, which was further validated in vitro. In addition, the selective PI3K agonist 740 y-p partially restored the inhibitory effects of TH on GBM cells. Finally, TH inhibited GBM progression in an orthotopic transplantation model by inactivating the PI3K/Akt/mTOR pathway in vivo. Conclusively, our results suggest that TH represses GBM progression by inhibiting the PI3K/Akt/mTOR signaling pathway in vitro and in vivo, and provides new insight for the treatment of GBM patients.

CDs-ICG@BSA nanoparticles for excellent phototherapy and in situ bioimaging.

For the diagnosis and treatment of cancer, a great challenge is the fabrication of straightforward, non-toxic, multifunctional green nanomaterials. In this study, carbon quantum dots self-assembled with indocyanine green dye at bovine serum albumin for phototherapy and in situ bioimaging are produced by a flexible hydrothermal method. We find that the synthesized nanoparticles have high tumor photothermal therapeutic activity when exposed to 808 nm light, with a photothermal conversion efficiency up to 61 %. The phototoxicity study revealed the excellent phototherapy of the nanoparticles mainly arises from photothermal therapeutic effect other than photodynamic therapy effect. Simultaneously, it allows biological imaging in the visible and near-infrared ranges because of the significant absorption at 365 nm and 840 nm. The current work offers a simple, environmentally friendly, and reasonable method for developing photothermal drugs with a high photothermal conversion efficiency in the near-infrared region, as well as good biosafety for multifunctional nanomaterials for bioimaging tumor diagnosis and direct phototherapy.

Research progress of music therapy in lung cancer surgery / 中国胸心血管外科临床杂志

@#Music has a powerful influence on people’s psychology and emotions. Many clinical research reports confirm that music therapy can directly affect and improve people’s psychological and physiological status, alleviate patients’anxiety and other adverse physiological emotions, improve the effectiveness of surgical treatment, and promote rapid recovery. Lung cancer surgery has the characteristics of great trauma, high incidence of postoperative complications and poor prognosis. Therefore, music therapy has its unique advantages for lung cancer. With the rapid development of thoracic surgery (ERAS), as an important part of psychological intervention, music therapy plays an irreplaceable role in the surgical treatment of lung cancer. This article reviews the impact of music therapy on anxiety in lung cancer surgery.