1.
Bioorg Med Chem Lett
; 12(1): 45-9, 2002 Jan 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11738570
RESUMEN
A series of structurally novel small molecule inhibitors of human alpha-thrombin was prepared to elucidate their structure-activity relationships (SARs), selectivity and activity in vivo. BMS-189664 (3) is identified as a potent, selective, and orally active reversible inhibitor of human alpha-thrombin which is efficacious in vivo in a mouse lethality model, and at inhibiting both arterial and venous thrombosis in cynomolgus monkey models.