RESUMEN
The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10-dynoic acid. The respective EC(50) values for melanin biosynthesis inhibition were 1.8 and 2.3 µg/mL for 1 and 2.
Asunto(s)
Artemisia/química , Melaninas/antagonistas & inhibidores , Melanoma Experimental/tratamiento farmacológico , Extractos Vegetales/farmacología , Alcamidas Poliinsaturadas , Neoplasias Cutáneas/tratamiento farmacológico , alfa-MSH/antagonistas & inhibidores , Animales , Supervivencia Celular/efectos de los fármacos , Humanos , Concentración 50 Inhibidora , Espectroscopía de Resonancia Magnética , Melaninas/biosíntesis , Melanoma Experimental/patología , Ratones , Extractos Vegetales/química , Alcamidas Poliinsaturadas/química , Alcamidas Poliinsaturadas/aislamiento & purificación , Alcamidas Poliinsaturadas/farmacología , Neoplasias Cutáneas/patología , Células Tumorales Cultivadas , alfa-MSH/metabolismoRESUMEN
An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobavachalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.