1.
Fitoterapia
; 130: 265-271, 2018 Oct.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30243779
RESUMEN
Gracilistones A (1) and B (2), two new eudesmane-type sesquiterpenoids with an unusual tetrahydrofuran-fused 6/6/5 tricyclic ring system, were obtained from Acanthopanax gracilistylus under the guidance of LC-MS investigation. Their structures and absolute configurations were assigned by extensive spectroscopic analyses and quantum calculation methods. Compounds 1 and 2 showed potent inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages, compared with the positive control L-NMMA. In addition, compounds 1 and 2 were also evaluated for their antioxidant (DPPH⢠and ABTSâ¢+) and xanthine oxidase (XO) inhibitory activities, and they exhibited weak inhibitory effects at 100⯵M.