RESUMEN
A new triterpenoid saponin, 3-O-ß-D-glucopyranosyl-(1â2)-ß-D-glucopyranosyl subprogenin D (1), together with six known triterpenoids: subprogenin D (2), abrusgenic acid (3), triptotriterpenic acid B (4), abruslactone A (5), abrusogenin (6) and abrusoside C (7) were isolated from the leaves and stems of Abrus precatorius. Their structures were elucidated on the basis of physical and NMR analysis, respectively. Compounds 5 and 6 showed moderate cytotoxicity against MCF-7, SW1990, Hela, and Du-145 cell lines. Compounds 1, 2 and 4 were isolated from this plant for the first time.
Asunto(s)
Abrus/química , Antineoplásicos Fitogénicos/aislamiento & purificación , Extractos Vegetales/aislamiento & purificación , Saponinas/aislamiento & purificación , Triterpenos/aislamiento & purificación , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Línea Celular Tumoral , Supervivencia Celular/efectos de los fármacos , Humanos , Concentración 50 Inhibidora , Ácido Oleanólico/análogos & derivados , Ácido Oleanólico/química , Ácido Oleanólico/aislamiento & purificación , Extractos Vegetales/química , Extractos Vegetales/farmacología , Saponinas/química , Saponinas/farmacología , Triterpenos/química , Triterpenos/farmacologíaRESUMEN
The new triterpenoid taraxerol-3-beta-O-tridecyl ether was isolated from the aerial part of Derris triofoliata. The structure was established on the basis of spectral data.