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1.
Nat Prod Res ; 34(22): 3205-3211, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-30663369

RESUMEN

Vicia sativa L. (common vetch) is a potential food source for both human beings and animals because of its abundant nutritional composition. There is a lack of phytochemical study on the whole plant, and thus the objective of this study was to investigate the isolation of phytochemicals and evaluate their biological activities. A new flavanol, (2R,3S)-3,3'-dihydroxy-4',7-dimethoxyflavanol (1), together with nine known compounds, two flavones (2-3), one coumarin (4), and six oleanane triterpenoids (5-10), was obtained from Vicia sativa L.. The structure of the new compound 1 was determined via its NMR spectra, IR and CD data. Compound 3 displayed the potential of the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging effect in antioxidant test. In terms of cytotoxic activities, compound 3 showed moderate cytotoxic activities against three human tumor cells, especially HeLa cells.


Asunto(s)
Antioxidantes/farmacología , Fitoquímicos/farmacología , Vicia sativa/química , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Antioxidantes/química , Dicroismo Circular , Flavonas/análisis , Células HL-60 , Células HeLa , Humanos , Espectroscopía de Resonancia Magnética , Estructura Molecular , Fitoquímicos/análisis , Fitoquímicos/química , Extractos Vegetales/química , Hojas de la Planta/química , Tallos de la Planta/química , Triterpenos/análisis
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