Studies on newly recognized chronic sialadenitis / 北京大学学报(医学版)

Some kinds of chronic sialadenitis were recognized during the recent years. They have specific pathogenesis, clinical and histopathologic appearances, and require specific treatment. IgG4-related sialadenitis (IgG4-RS) is one of the immune-mediated diseases, characterized by tumefactive lesions. The incidence of IgG4-RS obviously increased during the past 30 years. The study on the potential relationship between occupational exposure to chemical substances and the incidence of IgG4-RS showed that subjects with occupational exposure to agents known to cause IgG4-RD had an increased risk for IgG4-RS. Surgical excision of involved SMG could not control the disease progression, which is not recommended for treatment of IgG4-RS. The combination of glucocorticoid and steroid-sparing agents is effective for treating IgG4-RS, and restores salivary gland function. Radioiodine induced sialadenitis (RAIS) is one of the common complications of postoperative adjuvant treatment of differentiated thyroid cancer by 131I. The incidence of the disease is related to radiation dosage. Clinically, the patients suffered from swelling and tenderness in the buccal or submandibular regions, especially during the mealtime. Imaging appearances are similar to those of chronic obstructive sialadenitis. Conservative managements, such as gland massage, sialagogues, are the mainstream methods in the treatment of RAIS. Sialendoscopy is feasible for RAIS, but not as effective as conventional obstructive sialadenitis (COS). Therefore the prevention of RAIS is crucial. Eosinophilic sialodochitis (ES) is a new type of chronic inflammatory disease of the salivary gland related to allergy. It has characteristics of swelling of multiple major salivary glands, strip-like gelatinous plugs discharged from the duct orifice of the gland, elevated level of serum IgE and eosinophils in peripheral blood, infiltration of eosinophils and IgE positive plasma cells in the tissues, allergic history, increased expression of allergy-related cytokines, such as IL-4, IL-5, IL-13, and eotaxin, which suggest allergic reactions as a potential pathogenesis of the disease. The clinical, laboratory, histological, and immunohistochemical characteristics of ES are significantly different from conventional obstructive sialadenitis (COS). Therefore, it is suitable to separate ES from COS. Conservative managements, such as self-maintenance therapy and anti- allergic modality are the choices of treatment for ES. Based on the results of our comprehensive studies a new classification of chronic sialadenitis is suggested.

Study on Identification Characteristics of Dichrocephala auriculata(Thunb.) Druce / 广州中医药大学学报

Objective To identify the pharmacognosy features of Dichrocephala auriculata(Thunb.)Druce,and to summarize its identification characteristics,so as to lay a foundation for further study and development of the drug. Methods By original plant identification and microscopic identification methods,we observed the features of the whole plant of Dichrocephala auriculata(Thunb.)Druce. Results The morphological characteristics of the original plant showed as follows:the whole aerial part was covered with tomentum;roots belonged to taproot root system;the alternate leaves were long oval-shaped, pinnatipartite, or divided;flowers were small, presented as capitulum, arranging in umbrella-shape, with several outer layers of white flowers and several inner layers of yellow green flowers. Microstructure characteristics showed as follows:root vascular bundle was broad,and pericycle fiber bundles were found outside;stem vascular bundle had 8-25 cyclocytics,pericycle fibers were found outside, and the medulla was broad with myelinated fibers around;the upper and below epidermis of leaves had stomata and non-tentacle, and the main vein vascular of the leaf was collateral with vascula bundles upside and downside;the nonglandular hairs,starch grains,fibers,pollen grains,and tubes were shown in the powder of whole plant. Conclusion The above results are stable and reliable, and can be applied for pharmacognosy identification of Dichrocephala auriculata(Thunb.)Druce.

Medicine-separated moxibustion combined with healthy guidance for improving human sub-healthy state / 中国针灸

<p><b>OBJECTIVE</b>To observe results of medicine-separated moxibustion combined with healthy guidance for improving human sub-healthy state and to probe the mechanism.</p><p><b>METHODS</b>Fifty-two sub-healthy persons from community were selected with health valuation method of traditional Chinese medicine and were treated with healthy guidance and medicine-separated moxibustion at selected points according to causes of disease, syndrome, clinical manifestations. At the same time, changes of clinical physical and chemical indexes and clinical symptoms before and after treatment were monitored.</p><p><b>RESULTS</b>After treatment, clinical symptoms and natural killer cells (NK) activity significantly increased (P<0.05); complement C3 and C4 levels significantly decreased and IgG level significantly increased (both P<0.05).</p><p><b>CONCLUSION</b>Medicine-separated moxibustion combined with healthy guidance direction can regulate functions of zang- and fu-organs and elevate immunity in the people of sub-healthy state, so as to improve sub-healthy state and increase quality of life.</p>