RESUMEN
Versicolactones A-D (1-4), four new butyrolactones, along with four known butyrolactones (5-8) were isolated from the fermentation products of the endophytic fungus Aspergillus versicolor. The structures of compounds 1-4, including absolute configuration, were elucidated by interpretation of the NMR and CD data. Compound 2 was further confirmed by single-crystal X-ray diffraction analysis. In particular, compound 1 is the first naturally occurring butyrolactone possessing an unusual 2-oxopropyl group. More importantly, compounds 1 and 8 displayed significant antitobacco mosaic virus activities with inhibition rates of 46.4â% and 35.4â%, even more potent than the positive control ningnanmycin (30.8â%). Compound 1 also showed moderate cytotoxicity against A549 and MCF7 cells with IC50 values of 3.2 and 2.5 µM, respectively.
Asunto(s)
Antivirales/farmacología , Aspergillus/química , Productos Biológicos/farmacología , Lactonas/farmacología , Sesquiterpenos/farmacología , Virus del Mosaico del Tabaco/efectos de los fármacos , Adenocarcinoma/tratamiento farmacológico , Adenocarcinoma del Pulmón , Antineoplásicos/química , Antineoplásicos/aislamiento & purificación , Antineoplásicos/farmacología , Antineoplásicos/uso terapéutico , Antivirales/química , Antivirales/aislamiento & purificación , Productos Biológicos/química , Productos Biológicos/uso terapéutico , Neoplasias de la Mama/tratamiento farmacológico , Fermentación , Humanos , Concentración 50 Inhibidora , Lactonas/química , Lactonas/aislamiento & purificación , Lactonas/uso terapéutico , Neoplasias Pulmonares/tratamiento farmacológico , Células MCF-7 , Estructura Molecular , Sesquiterpenos/química , Sesquiterpenos/aislamiento & purificación , Sesquiterpenos/uso terapéuticoRESUMEN
Two new 7,8-secolignans, neglectahenols E and F (1 and 2), together with four known 7,8-secolignans (3-6), were isolated from the fruits of Schisandra neglecta. The structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities at the concentration of 20 µM. Compounds 1 and 6 showed high anti-TMV activities with inhibition rates of 38.2% and 32.7%, respectively. These rates are higher than that of a positive control. Compounds 2-5 also showed modest anti-TMV activities with inhibition rates in the range of 22.8-28.7%. These rates are close to that of a positive control.