Influence of Group Training Based on Psychological Capital Theory on Nursing Staff's Occupational Benefits and Job Satisfaction in an Infusion Preparation Center.

Context: While they play an increasingly important role in medication safety, nursing staff in an infusion preparation center also face high work intensity and high occupational-exposure risks. Psychological capital for nurses manifests as ab ability to overcome difficulties; nurses' perceptions of occupational benefits can enable them to think and function in a constructive and rational way in a clinical environment; and job satisfaction can influence the nursing quality. Objective: The study intended to investigate and analyze the influence of group training based on psychological capital theory on the nursing staff's psychological capital, occupational benefits, and job satisfaction in an infusion preparation center. Design: The research team performed a prospective, randomized controlled study. Setting: The study took place at the First Medical Center of the Chinese People's Liberation Army (PLA) General Hospital in Beijing, People's Republic of China. Participants: Participants were 54 nurses working in the infusion preparation center at the hospital between September 2021 and November 2021. Intervention: The research team randomly divided the participants into an intervention and a control group, each with 27 participants, using a random number list. Nurses in the intervention group received group training based on the psychological capital theory, while those in the control group received a routine psychological intervention. Outcome Measures: At baseline and postintervention, the study compared the scores for psychological capital, occupational benefits, and job satisfaction between the two groups. Results: At baseline, no statistically significant differences existed between the intervention and control groups on their scores related to psychological capital, occupational benefits, or job satisfaction. Postintervention, the intervention group's scores were significantly higher (1) for psychological capital-hope (P = .004), resilience (P = .000), optimism (P = .001), self-efficacy (P = .000) and total psychological capital score (P = .000); (2) for occupational benefits-career perception (P = .021), sense of belonging to a team (P = .040), and career benefit total score (P = .013); and (3) for job satisfaction-occupational recognition (P = .000), personal development (P = .001), relationships with colleagues (P = .004), the work itself (P = .003), workload (P = .036), management (P = .001), family and work balance (P = .001), and total score for job satisfaction (P = .000). Postintervention, no significant differences existed between the groups (P > .05): (1) for occupational benefits-identity of relatives and friends, self-growth, or nurse-patient relationships or (2) for job satisfaction-salary and benefits. Conclusions: Implementing group training based on psychological capital theory can improve the psychological capital, occupational benefits, and job satisfaction of nurses in the infusion preparation center.

Analysis of pharmacological mechanisms and targets mining of Wuzi-Yanzong-Wan for treating non-obstructive oligoasthenospermia.

As a classical traditional Chinese medicine, Wuzi-Yanzong-Wan (WZYZW) has been widely applied for several centuries to treat non-obstructive oligoasthenozoospermia (NOA), although its pharmacological mechanisms remain largely unknown. In this study, both plasma and urine metabolomics profiling was first analysed to explore the therapeutic mechanisms of WZYZW in NOA rats induced by removal of the unilateral testicle. Then, 106 identified compounds comprising WZYZW (our previous work), for which putative targets were discovered using systems pharmacology, were systematically analysed via mRNA microarrays to validate their putative targets. Finally, metabolomics-tested WZYZW-regulated metabolites were connected with validated targets using Spearman correlation analysis to further confirm the targets from a biological perspective. The results suggested that WZYZW plays key roles in modulating the concentrations of 18 metabolites in the metabolism of amino acids, lipids and so on, normalizing the metabolic phenotype and regulating metabolic disorders. Moreover, 27 targets of WZYZW (23 compounds) against NOA were validated, and metabolomics-tested metabolites were also found to be significantly related to these identified targets, suggesting that these targets and compounds are worthy of further research. This work offers the first systematic investigation of the efficacy of WZYZW against NOA and illustrates a practicable approach for explaining the molecular mechanisms of multicomponent drugs.

A developmental toxicity assay of Carpesii Fructus on zebrafish embryos/larvae.

Carpesii Fructus, the dried fruit of Carpesium abrotanoides L., has been used as a traditional Chinese medicine for centuries to kill intestinal parasites in children. It has been recorded as a mildly toxic medicine in the Chinese pharmacopoeia. However, little proof of its toxicology has been reported in modern pharmacology. This study investigated for the first time its developmental toxicity on zebrafish embryos/larvae from 6 to 96 h post-fertilization (hpf). In addition, the enzymes and genes associated with oxidative stress and apoptosis were tested to investigate the potential toxicologic mechanism preliminarily. The observation of toxicologic endpoints showed the developmental toxicity of Carpesii Fructus. Pericardial edema, yolk sac edema, bleeding tendency, and enlarged yolk were the most commonly occurring morphological changes observed in our study. According to the results of acridine orange staining and morphological observation, the developing heart was speculated to be the target organ of toxicity. Furthermore, Carpesii Fructus exposure changed the activities of defense enzymes, increased malondialdehyde (MDA) content, decreased caspase-3 activity, and altered mRNA levels of related genes (ogg1, p53, Cu/Zn-Sod, Mn-Sod, and Cat↓; Gpx↑) in zebrafish larvae, indicating that oxidative stress and additional apoptosis should have roles in the developmental toxicity of Carpesii Fructus. This is the first study that provides proof of modern pharmacology on the teratogenicity and possible toxicologic mechanism of Carpesii Fructus.