RESUMEN
RATIONALE AND OBJECTIVE: Although loudness dependence of auditory evoked potentials (LDAEPs) had been suggested as a noninvasive measure of central serotonin functions, recent studies suggest that LDAEP may be modulated by multiple neuromodulatory systems, such as dopamine. Here, we explore the relationship between LDAEP and dopamine and serotonin in the level of monoamine transporter availability. METHODS: Forty-nine healthy volunteers received LDAEP and single-photon emission computed tomography (SPECT) using [(99m)Tc] TRODAT and [(123)I] ADAM to approximate the availability of dopamine transporters (DATs) and serotonin transporters (SERTs). RESULTS: LDAEP was found to be positively associated with DAT, after adjusting for age and gender, and the log-transformed slope of loudness dependence at Cz was negatively associated with SERT. CONCLUSION: Our findings provide further evidence for the possible involvement of dopamine and serotonins in the genesis of LDAEP.
Asunto(s)
Encéfalo/diagnóstico por imagen , Encéfalo/fisiología , Proteínas de Transporte de Dopamina a través de la Membrana Plasmática/metabolismo , Potenciales Evocados Auditivos/fisiología , Percepción Sonora/fisiología , Proteínas de Transporte de Serotonina en la Membrana Plasmática/metabolismo , Estimulación Acústica/métodos , Adulto , Mapeo Encefálico , Cinanserina/análogos & derivados , Femenino , Humanos , Masculino , Persona de Mediana Edad , Compuestos de Organotecnecio , Radiofármacos , Análisis de Regresión , Tomografía Computarizada de Emisión de Fotón Único/métodos , Tropanos , Adulto JovenAsunto(s)
Benzofuranos/envenenamiento , Contaminación de Alimentos , Oligospermia/epidemiología , Oryza/envenenamiento , Aceites de Plantas/envenenamiento , Bifenilos Policlorados/envenenamiento , Espermatozoides/efectos de los fármacos , Adulto , Benzofuranos/farmacología , Dibenzofuranos Policlorados , Exposición a Riesgos Ambientales/efectos adversos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Oligospermia/etiología , Bifenilos Policlorados/farmacología , Embarazo , Efectos Tardíos de la Exposición Prenatal , Sistema de Registros , Capacitación Espermática/efectos de los fármacos , Motilidad Espermática/efectos de los fármacos , Taiwán/epidemiologíaRESUMEN
BACKGROUND: Researchers have hypothesized that bone mineral density (BMD) may be influenced by chemical compounds such as caffeine, phytoestrogen, fluoride, and many compounds that are contained in tea extracts. Hence, the relationship between habitual tea consumption and BMD is an interesting issue. METHODS: Based on an epidemiological survey, we enrolled 497 men and 540 women, 30 years and older, in our study. All subjects were questioned about their habit of tea consumption and other lifestyle characteristics by means of a structured questionnaire. Dual-energy x-ray absorptiometry was used to measure the BMD of the total body, lumbar spine (L1-L4), hip neck, and Ward triangle regions. RESULTS: Five hundred two subjects (48.4%) were habitual tea drinkers, with a mean duration of tea consumption of approximately 10 years. Compared with nonhabitual tea drinkers, subjects with habitual tea consumption of 6 to 10 years showed higher lumbar spine BMDs, and those with consumption of more than 10 years showed the highest BMDs of all measured regions. Under the multiple stepwise regression models, sex, age, body mass index, total physical activity, and habit of tea consumption were the major significant variables for the different BMD regions. Regarding the behavioral characteristics of tea consumption, the duration of tea consumption was the only independent determinant for the BMDs. CONCLUSION: Habitual tea consumption, especially for more than 10 years, has significant beneficial effects on BMD of the total body, lumbar spine, and hip regions in adults.