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1.
West Indian med. j ; 62(3): 201-204, Mar. 2013. tab
Artículo en Inglés | LILACS | ID: biblio-1045626

RESUMEN

AIM: Hypocalcaemia evaluation of the clinical, biochemical and radiological features of 91 infants with rickets who presented as hypocalcaemic convulsions. SUBJECTS AND METHODS: Ninety-one hypocalcaemic infants who were brought to hospital with convulsion and diag-nosed with rickets related to vitamin D deficiency according to their clinical, biochemical and radio-logical features were retrospectively reviewed. RESULTS: Mean values of the laboratory data were as follows: calcium 5.55 ± 0.79 mg/dL, phosphorus 4.77 ± 1.66 mg/dL, alkaline phosphatase 1525.5 ± 925.4 U/L and parathormone 256.8 ± 158.3 pg/mL. Serum 25-OH vitamin D levels were below normal (< 20 ng/mL) in 37 infants. CONCLUSION: Vitamin D deficiency should be considered in infants presenting with hypocalcaemia. To avoid complications such as convulsions, clinicians should give vitamin D supplementation to such infants.


OBJETIVO: Evaluación hipocalcémica de los aspectos clínicos, bioquímicos y radiológicos de 91 lactantes con raquitismo, que presentaron convulsiones por hipocalcemia. PACIENTES Y MÉTODOS: Noventa y un lactantes hipocalcémicos llevados al hospital con convulsiones y a quienes se les diagnosticó raquitismo asociado a la deficiencia de vitamina D de acuerdo con sus características, bioquímicas y radiológicas, fueron revisados retrospectivamente. RESULTADOS: Los valores medios de los datos de laboratorio fueron los siguientes: calcio 5.55 ± 0.79 mg/dL, fósforo 4.77 ± 1.66 mg/dL, fosfatasa alcalina 1525.5 ± 925.4 U/L, y paratohormona 256.8± 158.3 pg/mL. Los niveles séricos de la vitamina 25 (OH) D estuvieron por debajo de lo normal en 37 lactantes (< 20 ng/mL). CONCLUSIÓN: La deficiencia de vitamina D debe considerarse en los infantes que se presentan con hipocalcemia. A fin de evitar complicaciones tales como convulsiones, se les debe dar suplementos de vitamina D.


Asunto(s)
Humanos , Masculino , Femenino , Recién Nacido , Lactante , Preescolar , Raquitismo/etiología , Convulsiones/etiología , Deficiencia de Vitamina D/complicaciones , Hipocalcemia/etiología , Hormona Paratiroidea/sangre , Fósforo/sangre , Convulsiones/sangre , Vitamina D/sangre , Biomarcadores/sangre , Calcio/sangre , Estudios Retrospectivos , Fosfatasa Alcalina/sangre
2.
West Indian Med J ; 62(3): 201-4, 2013 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-24564040

RESUMEN

AIM: Hypocalcaemia evaluation of the clinical, biochemical and radiologicalfeatures of 91 infants with rickets who presented as hypocalcaemic convulsions. SUBJECTS AND METHODS: Ninety-one hypocalcaemic infants who were brought to hospital with convulsion and diag-nosed with rickets related to vitamin D deficiency according to their clinical, biochemical and radio-logicalfeatures were retrospectively reviewed. RESULTS: Mean values of the laboratory data were as follows: calcium 5.55 +/- 0.79 mg/dL, phosphorus 4.77 +/- 1.66 mg/dL, alkaline phosphatase 1525.5 +/- 925.4 U/L and parathormone 256.8 +/- 158.3 pg/mL. Serum 25-OH vitamin D levels were below normal (< 20 ng/mL) in 37 infants. CONCLUSION: Vitamin D deficiency should be considered in infants presenting with hypocalcaemia. To avoid complications such as convulsions, clinicians should give vitamin D supplementation to such infants.


Asunto(s)
Hipocalcemia/etiología , Raquitismo/complicaciones , Convulsiones/etiología , Fosfatasa Alcalina/sangre , Calcio/sangre , Preescolar , Femenino , Humanos , Hipocalcemia/sangre , Lactante , Recién Nacido , Masculino , Hormona Paratiroidea/sangre , Fósforo/sangre , Estudios Retrospectivos , Raquitismo/sangre , Convulsiones/sangre , Vitamina D/análogos & derivados , Vitamina D/sangre , Deficiencia de Vitamina D/sangre , Deficiencia de Vitamina D/complicaciones
4.
Arch Orthop Trauma Surg ; 121(7): 426-8, 2001 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-11510911

RESUMEN

The benefits of various minerals and vitamins on fracture healing have been demonstrated in animal models. Vitamin C is an essential substance in fracture healing but has not been studied previously on an experimental basis. Sixteen rats were grouped randomly into control and vitamin C-supplemented groups. The right tibias of all rats were fractured by digital manipulation. One group received single high dose of vitamin C intramuscularly. On the 5th, 10th, 15th, and 20th days, two rats from each group were killed and the tibias examined under light microscopy. It was seen that the vitamin C-supplemented group went through the stages of fracture healing faster compared with the control group.


Asunto(s)
Ácido Ascórbico/administración & dosificación , Curación de Fractura/efectos de los fármacos , Fracturas Óseas/tratamiento farmacológico , Animales , Fracturas Óseas/patología , Ratas , Ratas Wistar
5.
Eat Weight Disord ; 3(1): 46-9, 1998 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-11234255

RESUMEN

UNLABELLED: Acarbose is an alpha-glucosidase inhibitor which reversibly inhibits oligosaccharidase and disaccharidase at the brush border of the small intestine. The aim of this study was to observe its effectiveness in the treatment of obesity. METHODS: Two groups of 25 obese women were put on a 15 kcal/kg/day low-calorie diet for 12 weeks. One group (the study group) received 150 mg/day acarbose for the first 2 weeks and 300 mg/day acarbose for the remaining 10 weeks. The second group (controls) received no additional treatment. Body weight, BMI, skinfold thickness, serum lipids, OGTT, and insulin and C-peptide responses to OGTT were assessed before and after the study. RESULTS: Body weight, BMI and skinfold thickness decreased significantly in both groups. Basal insulin and triglyceride levels in the study group, total and LDL cholesterol and triglyceride levels in the control group decreased significantly. No difference was found between the two groups when these decrements were compared, but the triglyceride level fell more in the control group. CONCLUSION: Additional acarbose therapy is not more beneficial than low-calorie diet therapy alone.


Asunto(s)
Acarbosa/administración & dosificación , Obesidad/tratamiento farmacológico , Acarbosa/efectos adversos , Adolescente , Adulto , Índice de Masa Corporal , Péptido C/metabolismo , LDL-Colesterol/sangre , Terapia Combinada , Dieta Reductora , Relación Dosis-Respuesta a Droga , Esquema de Medicación , Prueba de Tolerancia a la Glucosa , Humanos , Insulina/sangre , Persona de Mediana Edad , Obesidad/sangre , Grosor de los Pliegues Cutáneos , Triglicéridos/sangre
6.
Eat Weight Disord ; 3(3): 136-40, 1998 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-10728163

RESUMEN

OBJECTIVE: Acarbose, a potent alpha-glucosidase inhibitor, provides a new concept for the treatment of metabolic disorders, and particularly diabetes mellitus. It reduces the postprandial blood glucose increment and insulin response. For this reason the drug has been successfully used not only in the treatment of type 1 and type 2 diabetes, but also in the management of reactive hypoglycemia and dumping syndrome. The primary aim of the present study is to evaluate the long-term effect of acarbose in reducing hypoglycemic symptoms and influencing laboratory measurements in patients with the diagnosis of reactive hypoglycemia. DESIGN AND METHODS: 21 non-obese (BMI < 27 kg/m2) patients (6 males, 15 females) complaining of postprandial symptoms suggesting hypoglycemia and who showed blood glucose values of < 54 mg/dl on one or more occasions during a 5 h oral glucose tolerance test (OGTT) were selected. RESULTS: Before treatment, ingestion of glucose decreased plasma glucose levels at the 3rd and 4th hours, the lowest levels being 39 mg/dl and 45 mg/dl respectively. Eighteen patients had hypoglycemic symptoms during OGTT. Following 3 months of acarbose treatment, the lowest plasma glucose levels at the 3rd and 4th hours increased to 67 mg/dI and 75 mg/dI respectively. Plasma insulin and c-peptide levels were reduced between the 1st and 5th hours, but only the 1st and 2nd hour decrements were statistically significant. The area under the curve (AUC) between 0-300 minutes for insulin was not significant. Plasma glucose levels were significantly increased during the last 3 hours. The AUC for glucose was not significantly changed. Frequency of hypoglycemic attacks was reduced from 4 times a week to 1. C-peptide levels in 24-hour urine collection did not change significantly: 45 micrograms/I and 56 micrograms/I respectively before and after treatment. CONCLUSIONS: These results confirm that acarbose may be of value in preventing reactive hypoglycemia by reducing the early hyperglycemic stimulus to insulin secretion, and in the treatment of reactive hypoglycemia.


Asunto(s)
Acarbosa/administración & dosificación , Inhibidores Enzimáticos/administración & dosificación , Inhibidores de Glicósido Hidrolasas , Hipoglucemia/tratamiento farmacológico , Acarbosa/efectos adversos , Adulto , Péptido C/sangre , Inhibidores Enzimáticos/efectos adversos , Femenino , Prueba de Tolerancia a la Glucosa , Humanos , Hipoglucemia/sangre , Insulina/sangre , Masculino , Persona de Mediana Edad
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