RESUMEN
BACKGROUND: In 1979 in Taiwan, about 2000 people were poisoned by cooking oil contaminated with heat-degraded polychlorinated biphenyls (PCBs). Victims developed chloracne and other symptoms; the illness is called Yucheng (oil disease). The chemicals persist in the victims' bodies and some are toxic to the female reproductive system in experimental animals. METHODS: In 1993-1994, we identified the living Yucheng women and neighbourhood controls and interviewed them about their reproductive experience. Of the 596 living Yucheng women aged 30-59 years, we found 368, and interviewed 356. We identified 329 controls, and interviewed 312. RESULTS: Of the Yucheng women, 16% reported abnormal menstrual bleeding compared to 8% (P < 0.05) of control women; 4.2% versus 1.7% reported a stillbirth since 1979 (P = 0.068). Other characteristics of the menses, fertility, frequency of intercourse, and age at menopause appeared unaffected. More of the Yucheng women reported that one of their offspring had died during childhood (10.2% versus 6.1%, P < 0. 05), and that they had decided to limit childbearing because of health problems (7% versus 2%, P = 0.01). CONCLUSIONS: These findings suggest that high level PCB/polychlorinated dibenzofuran (PCDF) exposure has some effect on female endocrine and reproductive function.
Asunto(s)
Contaminación de Alimentos , Menstruación/efectos de los fármacos , Bifenilos Policlorados/envenenamiento , Reproducción/efectos de los fármacos , Adulto , Culinaria , Femenino , Estudios de Seguimiento , Humanos , Mortalidad Infantil , Recién Nacido , Persona de Mediana Edad , Aceites de Plantas , Intoxicación/epidemiología , Estudios Retrospectivos , Taiwán/epidemiologíaRESUMEN
In 1979, a mass poisoning of more than 2000 people occurred in central Taiwan due to consumption of rice-bran oil contaminated with PCBs and their heat-degraded byproducts. The incident was later referred to as Yucheng (oil disease). Serum samples from 56 women with the 1979 exposure were collected in February 1992 and analyzed for their contaminant content using sample enrichment and isotope dilution mass spectrometry. In most of the samples, levels of PCDFs and PCBs were detectable, and the median values of 2,3,4,7,8-PCDFs and 1,2,3,4,7,8-PCDFs were 1,030 and 2,220 ng/kg serum lipid, respectively. The median level of the total PCBs on a whole weight basis was 8,730 ng/kg. The PCB/PCDF concentrations in Yucheng women 14 years after the toxic exposure were still one to two orders of magnitude higher than controls. Concentrations of PCB levels in 1992 were positively correlated with the 1980-1981 measured PCB levels in these women and both PCBs and PCDFs were negatively correlated with the total duration when these women breast fed their children between 1979 and 1992. It is concluded that serum levels of congener-specific PCBs/PCDFs in exposed women are good indicators of previous exposure and may provide important information for more reliable estimation of dose-response relationship.
Asunto(s)
Benzofuranos/sangre , Contaminación de Alimentos , Aceites de Plantas/envenenamiento , Bifenilos Policlorados/sangre , Dibenzofuranos Policlorados , Femenino , Humanos , Oryza , Factores de TiempoRESUMEN
In 1979, a mass poisoning involving some 2,000 persons occurred in central Taiwan from cooking oil contaminated by polychlorinated biphenyls (PCBs) and their heat-degraded byproducts, including polychlorinated dibenzofurans (PCDFs). The responsible health department registered cases for clinical purposes between 1979 and 1983. The exposed persons are referred to as the "yucheng" (oil disease) cohort. PCBs and PCDFs are toxic chemicals widely dispersed in the environment and in human tissue, which persist long after exposure. The consequences of exposure to these agents are not well understood. We traced the cohort through December 31, 1991, and compared overall and cause-specific mortality of 1,837 "yucheng" subjects with age, gender, and calendar time-specific mortality rates for the Taiwan general population. Eighty-three deaths were identified from 23,404 observed person-years. Even though the overall standardized mortality ratio (SMR) was 0.8 (95% confidence interval (CI) 0.7-1.0), there was a substantial elevation in the mortality rate for chronic liver disease and cirrhosis (10 deaths, SMR = 2.7, 95% CI = 1.3-4.9). Mortality from malignant neoplasms and other causes was not significantly different from that of the Taiwan population. PCB/PCDF exposure appears to promote the development of severe liver disease, perhaps in combination with known risk factors such as infection with hepatitis B virus. Further follow-up of this young cohort is necessary to see if the consequences include hepatic cancer.
Asunto(s)
Benzofuranos/envenenamiento , Contaminación de Alimentos , Cirrosis Hepática/mortalidad , Hepatopatías/mortalidad , Oryza/envenenamiento , Aceites de Plantas/envenenamiento , Bifenilos Policlorados/envenenamiento , Adolescente , Causas de Muerte , Enfermedad Hepática Inducida por Sustancias y Drogas , Niño , Preescolar , Enfermedad Crónica , Intervalos de Confianza , Femenino , Estudios de Seguimiento , Humanos , Lactante , Recién Nacido , Cirrosis Hepática/inducido químicamente , Masculino , Persona de Mediana EdadRESUMEN
OBJECTIVE: To evaluate the health-related fitness of geriatric Tai Chi Chuan (TCC) practitioners. DESIGN: Case-control study of a TCC group and a group of sedentary controls. SETTING: Research project at a hospital-based exercise physiology laboratory. PARTICIPANTS: Seventy-six community-dwelling senior persons (mean age 69.3 +/- 3.9 yr), a TCC group that included 22 men and 19 women and a control group of sedentary subjects that included 18 men and 17 women with matched age and body size. INTERVENTION: The TCC group had practiced TCC regularly for 11.8 +/- 5.6 years, with an exercise frequency of 4.3 +/- 1.3 times per week. Each session included 20 minutes of warm-up, 24 minutes of TCC training, and 10 minutes of cool-down. Exercise intensity was estimated to exceed 70% of maximal heart rate (HRmax). MAIN OUTCOME MEASURE: Breath-by-breath measurement of cardiorespiratory function was obtained during the incremental exercise of leg cycling. Flexibility of thoracic/lumbar spine was measured by an electronic inclinometer. Percentages of body fat was calculated from biceps and subcapsular skinfolds. RESULTS: In the peak exercise, men in the TCC group showed 19% higher peak oxygen uptake (VO2peak) in comparison with their sedentary counterparts (26.9 +/- 4.7 mL/kg/min vs 21.8 +/- 3.1 mL/kg/min). Women in the TCC group also showed 18% higher VO2peak than in the sedentary group (20.1 +/- 2.9 mL/kg/ min vs 16.5 +/- 2.0 mL/kg/min). The TCC group also showed higher oxygen uptake at the ventilatory threshold. In addition, the TCC practitioners were characterized by greater flexibility and lower percentage of body fat in comparison with their sedentary counterparts. CONCLUSION: It is concluded that TCC training has benefits for health-related fitness, and it may be prescribed as a suitable conditioning exercise for the elderly.
Asunto(s)
Composición Corporal , Fenómenos Fisiológicos Cardiovasculares , Artes Marciales/fisiología , Respiración/fisiología , Anciano , Estudios de Casos y Controles , Prueba de Esfuerzo , Femenino , Humanos , Masculino , Pruebas de Función Respiratoria , Columna Vertebral/fisiología , Yin-YangRESUMEN
Three saponins have been isolated from the leaves of Panax japonicus ssp. elegantior var. major (Burkill) Wu et Feng collected in Sichuan, China. They were identified as ginsenoside-Rd (0.5%), ginsenoside-Rg2 (0.025%) and ginsenoside-Rg1 (0.016%), respectively, based on the chemical and spectral analytical data obtained.