RESUMEN
Endothelial dysfunction is the major cause of vascular complications in diabetes. Teucrium polium L. is traditionally used for the production of antidiabetic herbal medicine. The cardiovascular effects of T. polium, has also been reported. As a result of this, the present study was conducted to evaluate the impacts of T. polium hydroalcoholic extract on the vasoreactivity and endothelial nitric oxide synthase (eNOS) and vascular cell adhesion molecule (VCAM)-1 genes expression as well in streptozotocin (STZ)-induced diabetic rat aorta. Male Wistar rats were randomly divided into six groups: control, diabetic, metformin, and three groups of T. polium (TP 100, TP 200, and TP 400). The control and diabetic groups were given normal saline; metformin group was given 300â¯mg/kg metformin; and T. polium groups were given 100, 200, and 400â¯mg/kg T. polium extract, daily by gavage for 6 weeks. T. polium extract was found to significantly reduce serum glucose level. It was also observed that metformin and T. polium extract significantly improved vasorelaxant response of aortic rings to acetylcholine (Ach). Real-time polymerase chain reaction (PCR) analysis showed that T. polium and metformin significantly increased eNOS expression, while it decreased VCAM-1 expressions in aortic tissue of diabetic rats. The results showed that T. polium extract could improve endothelial dysfunction by ameliorating the vasoreactivity and regulating eNOS and VCAM-1 gene expressions as well in STZ-induced diabetic rats' aorta.
Asunto(s)
Diabetes Mellitus Experimental/tratamiento farmacológico , Endotelio Vascular/fisiopatología , Regulación de la Expresión Génica , Óxido Nítrico Sintasa de Tipo III/genética , Extractos Vegetales/uso terapéutico , Teucrium/química , Molécula 1 de Adhesión Celular Vascular/genética , Vasodilatación/genética , Acetilcolina/farmacología , Animales , Aorta/efectos de los fármacos , Aorta/fisiopatología , Glucemia/metabolismo , Diabetes Mellitus Experimental/sangre , Diabetes Mellitus Experimental/genética , Diabetes Mellitus Experimental/fisiopatología , Regulación de la Expresión Génica/efectos de los fármacos , Masculino , Metformina/farmacología , Metformina/uso terapéutico , Óxido Nítrico Sintasa de Tipo III/metabolismo , Fitoterapia , Extractos Vegetales/farmacología , Ratas Wistar , Estreptozocina , Molécula 1 de Adhesión Celular Vascular/metabolismo , Vasodilatación/efectos de los fármacosRESUMEN
Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease. NAFLD is considered a multifactorial disease and a clinically relevant hepatic manifestation of metabolic syndrome. NAFLD is often accompanied by a constellation of metabolic and non-metabolic alterations, like dyslipidemia, insulin resistance in the liver and peripheral tissues, inflammation and oxidative stress; therefore, treatment of NAFLD should be directed at correcting all of these disturbances. The natural polyphenol curcumin has been the subject of increasing research for the treatment of NAFLD due to its lipid-modifying, antioxidant, anti-inflammatory, insulinsensitizing, anti-steatotic, and anti-fibrotic properties. The therapeutic efficacy of curcumin has been demonstrated in several experimental models of NAFLD, however, clinical evidence is still scarce. The present review summarizes the current knowledge on the impact of curcumin supplementation on different biochemical and histopathological features of NAFLD.