Clinical effect of pantoprazole combined with traditional Chinese medicine in the treatment of gastroesophageal reflux / 中华消化内镜杂志

To investigate the clinical effect of pantoprazole combined with traditional Chinese medicine for gastroesophageal reflux. A total of 50 cases of gastroesophageal reflux selected from January 2019 to December 2019 in Aviation General Hospital were randomly divided into the control group and the observation group. The control group was given pantoprazole, and the observation group was given traditional Chinese medicine combined with pantoprazole. Both groups were treated for 28 days. The recovery of clinical symptoms, status of esophageal mucosa by endoscopy and the incidence of adverse reactions were compared between the two groups. The clinical symptoms and status of esophageal mucosa in both group were obviously improved. Efficiency of the observation group was significantly higher than that of the control group( P<0.05). No serious adverse reactions happened during treatment. Pantoprazole combined with traditional Chinese medicine has definite clinical effects in the treatment of gastroesophageal reflux, which can improve the clinical symptoms and the recovery of esophageal mucosa of patients with high safety.

Clinical Observation of Electroacupuncture at Jiaji (EX-B2) Points for Primary Trigeminal Neuralgia / 上海针灸杂志

Objective With ordinary acupuncture as the control, to observe the feasibility and effectiveness of electroacupuncture at Jiaji (EX-B2) points in treating primary trigeminal neuralgia.Method Forty patients with primary trigeminal neuralgia were randomized into a group of electroacupuncture at Jiaji points and an ordinary acupuncture group, 20 cases in each group. In the electroacupuncture group, Jiaji of C2and T1on the affected side were selected, while the points were selected by following the Acupuncture-moxibustion Therapeuticsin the ordinary acupuncture group. Carbamazepine (CBZ) was taken as the basic treatment for the two groups. A treatment course (3 weeks) was observed, and follow-up study was conducted every 4 weeks for a total of 12 weeks. The dose of CBZ, Visual Analogue Scale (VAS) and Short-form McGill Pain Questionnaire (SF-MPQ) scores at each time point were recorded. The changes of the index in the two groups at each time point were compared.ResultAt the end of the treatment (the third week), the dose of CBZ, VAS and SF-MPQ scores all declined in the two groups, and the between-group differences were statistically insignificant (P>0.05). The follow-up study in the 7th week showed that the data of the observed indexes all decreased in the two groups, while the electroacupuncture group presented a more significant efficacy, and the between-group differences were statistically significant (P<0.05). The follow-up studies in the 11th and 15th weeks showed that the data of the observed indexes continued to decline in the electroacupuncture group but began to increase in the ordinary acupuncture group, and the between-group differences were statistically significant (P<0.001).Conclusion Electroacupuncture at Jiaji points and ordinary acupuncture both can reduce the dose of CBZ for patients with primary trigeminal neuralgia, improve pain and other discomforts as well as the negative emotions, but electroacupuncture at Jiaji can produce a more significant long-term efficacy compared to the ordinary acupuncture.

Effect of liraglutide combined with insulin on HbA1c, T lymphocyte subsets and islet function in patients with type 1 diabetes / 中国生化药物杂志

Objective To investigate the effect of liraglutide combined with insulin on the HbA1c, T lymphocyte subsets and islet function in patients with type 1 diabetes.Methods 46 cases from endocrinology department of Tangshan Traditional Chinese Medicine Hospital with type 1 diabetes were selected and randomly divided into two groups each group had 23 patients.Control group were given recombinant human insulin to control blood sugar according to the blood glucose level, and experimental group were given liraglutide on the basis of control group.HbA1c, T lymphocyte subsets, C-Peptide ( CP) and islet function were compared after treatment.ResuIts Compared with control group after treatment, HBAlc level in experimental group was lower (P<0.05); CD4 +T was higher, CD8 +T was lower, and CD4 +/CD8 +T was higher (P<0.05); the fasting plasma glucose (FPG) level was lower (P<0.05);2-hour postprandial blood glucose (2 hPG) was lower (P<0.05); CP and 2-hour postprandial C-Peptide (2 hCP) were higher (P<0.05).There was no significant difference in liver and kidney function between two groups.ConcIusion Liraglutide combined with insulin could significantly reduce serum glycated hemoglobin level, increase CD4 +T level and reduce CD8 +T level, improve islet function in patients with type 1 diabetic.

Stevioside protects LPS-induced acute lung injury in mice.

Stevioside, a diterpene glycoside component of Stevia rebaudiana, has been known to exhibit anti-inflammatory properties. To evaluate the effect and the possible mechanism of stevioside in lipopolysaccharide (LPS)-induced acute lung injury, male BALB/c mice were pretreated with stevioside or dexamethasone 1 h before intranasal instillation of LPS. Seven hours later, tumor necrosis factor-α, interleukin-1ß, and interleukin-6 in bronchoalveolar lavage fluid (BALF) were measured by using enzyme-linked immunosorbent assay. The number of total cells, neutrophils, and macrophages in the BALF were also determined. The right lung was excised for histological examination and analysis of myeloperoxidase activity and nitrate/nitrite content. Cyclooxygenase 2 (COX-2), inducible NO synthase (iNOS), nuclear factor-kappa B (NF-κB), inhibitory kappa B protein were detected by western blot. The results showed that stevioside markedly attenuated the LPS-induced histological alterations in the lung. Stevioside inhibited the production of pro-inflammatory cytokines and the expression of COX-2 and iNOS induced by LPS. In addition, not only was the wet-to-dry weight ratio of lung tissue significantly decreased, the number of total cells, neutrophils, and macrophages in the BALF were also significantly reduced after treatment with stevioside. Moreover, western blotting showed that stevioside inhibited the phosphorylation of IκB-α and NF-κB caused by LPS. Taken together, our results suggest that anti-inflammatory effect of stevioside against the LPS-induced acute lung injury may be due to its ability of inhibition of the NF-κB signaling pathway. Stevioside may be a promising potential therapeutic reagent for acute lung injury treatment.

Clinical study on the method of reinforcing qi nourishing yin and promoting blood circulation to remove blood stasis in the treatment of restenosis after percutaneous coronary intervention / 国际中医中药杂志

Objective To observe the clinical effects of the method of reinforcing qi,nourish ing yin and promoting blood circulation to remove blood stasis in the treatment of restenosis after percutaneous coronary intervention.Methods 60 coronary heart disease patients who had accepted PCI treatment and occurred restenosis were randomly recruited into a control group and a treatment group,30 eases in each group.The control group received conventional therapy.The treatment group was treated with conventional therapy combined with TCM of reinforcing qi,nourishing yin and promoting blood circulation to remove blood stasis.Both groups were treated for 6 months.The clinical symptoms,coronary angiography or coronary artery CTA,blood lipids were observed.Results The total effective rate was 93.33％ and 66.67％ in the treatment group and the control group respectively,showing statistical difference (x2=8.787,P＜0.05).The patients' clinical symptoms in the treatment group were improved,such as chest pain,chest tightness,shortness of breath,fatigue,dry mouth [The scores were respectively(1.07± 1.01)、(1.33±1.21)、(1.47±1.17)、(1.53±1.14)、(1.53± 1.01),(P＜0.05) ].The treatment group demonstrated a significantly better therapeutic results than the control group [Thescoreswererespectively(2.07±1.53)、(2.27±1.46)、(3.73±1.46)、(3.73±1.87)、(3.13±1.63),(P＜0.05) ].The results of coronary angiography or coronary artery CTA showed that the narrow degree in the treatment group was no more aggravating and it had no new restenosis.After the treatment,the level of CHOL、TG、HDL-C、LDL-C in the treatment group was improved [They were respectively (4.55±0.44)mmol/L、(1.81±0.56)mmol/L、(1.26±0.38)mmol/L、(2.25±0.49)mmol/L,(P＜0.05) ].The improvement in CHOL、TG、LDL-C of the treatment group was better than that of the control group [They were respectively (4.86±0.63)mmol/L、(2.29±1.06)mmol/L,(2.60±0.73)mmol/L,(P＜0.05)].Conclusion The method of reinforcing qi,nourishing yin and promoting blood circulation to remove blood stasis could improve the patients clinical symptoms and blood lipids,and therefore spreventing restenosis.

Effects of Jiaji Electroacupuncture on Cortical Somatosensory Evoked Potentials in Rats with Spinal Cord Injury / 中国康复理论与实践

@#Objective To explore the effects of Jiaji electroacupuncture on the cortical somatosensory evoked potentials(CSEP) and promotion of the function recovery in rats with spinal cord injury(SCI).Methods The experiment was performed in the Medical Experimental Center of Heilongjiang University of Chinese Medicine from November 2008 to February 2009. ①Allen's injury model of T10 spinal cord was established in SD rats with strike force of 50 g·cm. Fifty SD rats were divided into sham operated group (group A), only SCI group (group B), MP treatment group (group C), MP treatment+6 hours after SCI electroacupuncture treatment group (group D) and MP treatment+2 weeks after SCI electroacupuncture treatment group (group E) by means of random number table, ten rats in each group. For groups C, D and E first administration of MP (30 mg/kg) was taken within half hour after SCI, followed by 23 successive administration of MP(5.4 mg/kg·h) for every each hour. Equal amount of normal saline was given group B as that for group B. For groups D and E, electroacupuncture treatment was began 6 hours and 2 weeks after SCI respectively. ② Acupuncture method: The filiform needles of 0.25 mm×25 mm were vertically inserted into the acupoints 5 mm deeply, which were located at 4 mm away from the bilateralis of the lower margin of T8 and T12spinous process. KWD-808Ⅱ Electroacupuncture instrument was adopted with dilatational wave of AC PULSE current. The current intensity was 2 mA and the frequency was 2/100 Hz. Needles were kept in muscles for 30 minutes once a day, until the 8th week. ③Observation index: BBB score was used once a week at 1st, 2nd, 4th, 6th, 8th weeks and CSEP was observed once a week at 2nd, 4th, 6th, 8th weeks after SCI. Results 50 SD rats were all involved in the result analysis. The BBB score and the latency period of P1 in CSEP in each group were normal, there was no significant difference among them(P>0.05); The BBB score was less and the latency period was longer in SCI groups than that in group A, the difference was significant(P<0.05); At 1st week after SCI: The score was less than 7 in SCI groups (P>0.05); At 2nd week: the score in groups C, D and E was more than that in group B (P<0.05),but there was no significant difference among groups C, D and E (P>0.05); There was no significant difference among the latency period of SCI groups (P>0.05); From 4th to 8th weeks the score was the most and the latency period was the shortest in group D among SCI groups (P<0.05); At 4th week: The score was more and the latency period was shorter in groups E and C than that in group B (P<0.05), but there was no significant difference between groups C and E (P>0.05); At 6th week: The score was more and the latency period was shorter in group E than that in groups C and B (P<0.05), the score was the fewest and the latency period was longest in group B among SCI groups (P<0.05); At 8th week: The score was more and the latency period was shorter in group E than that in groups C and B (P<0.05), but there was no significant difference among group C and B (P>0.05).Conclusion The Jiaji electroacupuncture has promotion of the function recovery in rats with SCI and the effects of early electroacupuncture intervention are better than the later stage.