[The clinical value of China Savin pollen extract used for skin prick test].

Objective:The aim of this study is to evaluate the effectiveness and safety of China Savin pollen extract which was used for skin prick test (SPT) in the diagnosis of China Savin pollen allergy. Method:Patients with diagnosis of allergic diseases were collected from Allergy Department of Peking Union Medical College Hospital. All patients were given SPT with China Savin pollen extract, and the mean wheal diameter (MWD) was measured after 15 minutes. Receiver operating characteristic curve (ROC) analysis was performed based on the results of serum specific immunoglobulin E (sIgE). The effectiveness of SPT in the diagnosis of China Savin pollen allergy was evaluated under different diagnostic cutoff values. Adverse events were also recorded to evaluate the safety. Result:A total of 1 029 patients were enrolled in this study without drop out case. There were 1 007 patients in full analysis set (FAS) and 765 patients in per protocol analysis set (PPS). The elimination rate was 25.66%. The area under the ROC curve of FAS is 0.814 (95%CI: 0.788-0.839); which of PPS is 0.829 (95%CI: 0.801-0.857). Based on the ROC curve of PPS, the optimal and the 95% specificity diagnostic cutoff values of MWD were 3.25 mm and 4.75 mm respectively. Based on different diagnostic cutoff value (3.00, 3.25 and 4.75 mm), the sensitivities of SPT with China Savin pollen extract were 0.740 0 (95%CI: 0.701 6-0.778 4), 0.700 (95%CI: 0.659 8-0.740 2) and 0.532 (95%CI: 0.488 3-0.575 7) respectively, whereas the specificity was gradually increased in sequence, which was 0.769 8 (95%CI: 0.719 1-0.820 5), 0.826 4 (95%CI: 0.780 8-0.872 0) and 0.950 9 (95%CI: 0.924 9-0.976 9) respectively. There were 7 adverse events observed among 6 patients (rate: 0.583%, 6/1 029). The manifestation was mild. There was no severe adverse event. Conclusion:SPT with China Savin pollen extract is an effective and safe tool for the diagnosis of China Savin pollen allergy. The effectiveness of diagnosis could be improved based on integration of medical history and different diagnostic threshold values of SPT.

[Experimental study on kidney invigorating and lipid reducing decoction-yishen jiangzhi tang in the treatment of chronic renal failure].

In exploring the effect of treatment of supporting the body resistance on chronic renal failure, a chronic renal failure model of rat was created by gastroperfusion of adenine and evaluation was made on the therapeutic effect of Kidney Invigorating and Lipid Reducing Decoction (KILRD). The mental state and body weight of the treated group have recovered well with polyuria and proteinurea improving, BUN and Creatinine decreasing, which appeared to be superior to the naturally recovered group. Renal pathological examination showed that: although the renal parenchymal damage was not reversed but its compensation was satisfactory with compensatory hypertrophy appearing in unaffected nephron. The dominant reaction in the affected area was polynucleomacrocytosis, foreign body granulamatosis, and interstitial lymphocytic infiltration, the fibrosis was inevident, while the above-mentioned condition in the naturally recovered group was relatively more serious, with fibrosis being observed. It was indicated that KILRD could increase the compensatory capacity and immunity, promote protein synthetization and improve renal function. The study on KILRD proved to be a significant conservative medical treatment for chronic renal failure.

[Clinical and CT analysis of 35 cases of lumbar disc herniation before and after non-operative treatment].

35 cases of lumbar disc herniation were examined by clinical diagnosis and CT scanning. The results showed that there were 36 disc herniation (1 case of dual disc herniation). The radius vector of disc was 6.3 mm and the transverse diameter was 18.6 mm. There were 30 cases with sac of dura mater of spinal cord or nerve roots pressed and adhesive, yellow ligaments pachismus, lateral recessus filling and narrow bony lumbar vertebral canal. All patients were treated by means of manipulation. The clinical results showed that 29 cases (82.8%) had superior effects and 33 cases were effective. The clinical effective rate was 94.2%. CT re-scanning showed that disc reposition completely returned was 6 cases, and partially returned was 24 cases. The successful rate of the reposition by manipulation was 83.3%. The clinical analysis and CT showed that herniation of lumbar disc could be repositioned by means of manipulation. The reposition of herniation of disc was a key factor in clinical results but was by no means the only one. With regard to long duration of illness, repeated invasion, combined narrow bony lumbar vertebral canal, and non-improved central type herniation after a long period of treatment, the herniation of disc should be treated by operation.