1.
Dearomative oxyphosphorylation of indoles enables facile access to 2,2-disubstituted indolin-3-ones.
Org Biomol Chem
; 20(29): 5721-5725, 2022 07 27.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35842851
RESUMEN
A highly efficient oxidative dearomatization of indoles with H-phosphorus oxides in the presence of TEMPO oxoammonium salt has been demonstrated. Through the intramolecular oxidative dearomatization of indoles and subsequent intermolecular nucleophilic addition with phosphorus nucleophile, a variety of structurally diverse arylphosphoryl and alkylphosphoryl indolin-3-ones were obtained in good yields with a broad substrate scope and high functional-group compatibility.