RESUMEN
Fourteen new sulphur-containing amides, glycocramides A-N (1-14), as well as nine known analogues (15-23) were isolated and characterized from Glycosmis craibii Tanaka. The chemical structures of new sulphur-containing amides 1-14 were ambiguously elucidated by extensive spectroscopic methods, while the known compounds 15-23 were identified by the comparison of their experimental spectral data with those described data in the literatures. The antiproliferative effects of all isolated sulphur-containing amides were evaluated in vitro. As a result, part of sulphur-containing amides showed remarkable inhibitory effects against MGC-803 cell line with IC50 values ranging from 13.12 ± 0.10 to 20.03 ± 0.13 µM. These research results suggest that the sulphur-containing amides are potentially to be developed as a new natural anti-tumor drugs.
Asunto(s)
Amidas , Rutaceae , Amidas/farmacología , Amidas/química , Estructura Molecular , Azufre , Extractos Vegetales/química , Rutaceae/química , Línea Celular TumoralRESUMEN
Two new cycloartane glycosides, cyprotusides A (1) and B (2), were isolated from the rhizomes of Cyperus rotundus. Their chemical structures were elucidated on the basis of IR, MS, NMR spectroscopic analyses coupled with chemical degradation. The potential antidepressant activity of the two compounds was evaluated. In the despair mice models, compounds 1 and 2 showed significant antidepressant activity.
Asunto(s)
Antidepresivos/aislamiento & purificación , Antidepresivos/farmacología , Cyperus/química , Medicamentos Herbarios Chinos/aislamiento & purificación , Medicamentos Herbarios Chinos/farmacología , Glicósidos/aislamiento & purificación , Glicósidos/farmacología , Rizoma/química , Triterpenos/aislamiento & purificación , Triterpenos/farmacología , Animales , Antidepresivos/química , Medicamentos Herbarios Chinos/química , Glicósidos/química , Ratones , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Triterpenos/químicaRESUMEN
A new steroidal saponin, named pumilum A (1), and a new phenolic glycoside, threo-1-(4'-hydroxy-2'-methoxyphenyl)-2-(2",4"-dihydroxyphenyl)-1,3-propanediol-4'-O-ß-D-glucopyranoside (7) were isolated from the methanolic extract of the bulbs of Lilium pumilum DC, along with five known steroidal saponins. Their chemical structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. In addition, the inhibitory activity of all the isolates on Na(+)/K(+) ATPase was evaluated.
Asunto(s)
Medicamentos Herbarios Chinos , Glicósidos , Lilium/química , Raíces de Plantas/química , ATPasa Intercambiadora de Sodio-Potasio/antagonistas & inhibidores , Medicamentos Herbarios Chinos/química , Medicamentos Herbarios Chinos/aislamiento & purificación , Medicamentos Herbarios Chinos/farmacología , Inhibidores Enzimáticos/química , Inhibidores Enzimáticos/aislamiento & purificación , Inhibidores Enzimáticos/farmacología , Glicósidos/química , Glicósidos/aislamiento & purificación , Glicósidos/farmacología , Espectroscopía de Resonancia Magnética , Estructura Molecular , Extractos Vegetales/química , Extractos Vegetales/farmacologíaRESUMEN
OBJECTIVE: To study aporphine alkaloids from Fissistigma oldhamii (Hemsl.) Merr. which is a characteristic plant of Guangxi. METHODS: Various chromatographic techniques were used to separate and purify the aporphine alkaloids. Their physical and chemical properties and spectral data were measured for structural elucidation. RESULTS: Four aporphine alkaloids were isolated from the fraction of total alkaloids of Fissistigma oldhamii (Hemsl.) Merr. They were identified as romucosine(I), xylopine(II), O-methylmoschatolineIII), oxoxylopine(IV). CONCLUSION: Compounds I is obtained from this plant for the first time.