RESUMEN
Five compounds were isolated from the traditional Chinese medicine Qianhu, roots of Peucedanum praeruptorum. Their structures were identified as 3'-angeloyloxykhellactone (IX), qianhucoumarin B (X), qianhucoumarin C (XI), Pd-III (XIII) and peucedanocoumarin III (XV). Among them, X and XI are new compounds, their absolute configurations were elucidated by chemical correlation with khellactones, as 3'(S)-acetoxy-4'(S)-hydroxy-3',4'-dihydroseselin(X) and 3'(S)-hydroxy-4'(S)-acetoxy-3',4'-dihydroseselin (XI). Compound IX was isolated from plants for the first time.
Asunto(s)
Cumarinas/aislamiento & purificación , Medicamentos Herbarios Chinos/química , Cumarinas/química , Estructura MolecularRESUMEN
Seven compounds were isolated from the traditional Chinese Medicine Qianhu, roots of Peucedanum praeruptorum Dunn. Their structures were identified as psoralen (II), 5-methoxypsoralen (III), 8-methoxypsoralen (IV), pteryxin (V), peucedanocoumarin II (VI), beta-sitosterol (VII) and qianhucoumarin A (VIII) by physico-chemical constants and spectral analyses (UV, IR, 1HNMR, 13CNMR, EIMS). VIII is a new compound with the structure of 3'(R)-hydroxy-4'(R)-tigloyloxy-3',4'-dihydroseslin. Its absolute configurations were determined by chemical correlation with known compounds. II, III, IV and VII were first isolated from this plant.
Asunto(s)
Cumarinas/aislamiento & purificación , Medicamentos Herbarios Chinos/química , Cumarinas/química , Furocumarinas/aislamiento & purificación , Estructura MolecularRESUMEN
Two new compounds hancogenin B (V) and hancoside A (VI) and four known compounds glucogenin C (I), cynatratoside A (II), glaucogenin A (III) and anhydrohirundigenin (IV) were isolated from the roots of Cynanchum hancockianum (Maxim) Al. Iljinski. Their structures were identified on the basis of spectral evidence. The fragmentation ways of 13:14, 14:15-secopregnenes in EIMS were outlined and the antitumor activity of II and the antiendotoxic activity of VI were also preliminarily tested in vitro.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Compuestos Bicíclicos con Puentes/aislamiento & purificación , Medicamentos Herbarios Chinos/química , Naftalenos/aislamiento & purificación , Pregnenolona/análogos & derivados , Saponinas/aislamiento & purificación , Secoesteroides/aislamiento & purificación , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Compuestos Bicíclicos con Puentes/química , Compuestos Bicíclicos con Puentes/farmacología , Humanos , Estructura Molecular , Naftalenos/química , Naftalenos/farmacología , Pregnenolona/química , Pregnenolona/aislamiento & purificación , Pregnenolona/farmacología , Saponinas/química , Saponinas/farmacología , Secoesteroides/química , Secoesteroides/farmacologíaRESUMEN
Four naphthoic acid esters including a new compound were isolated from the roots of Rubia cordifolia L. The new one was named as rubilactone and its structure was elucidated as 3'-carbomethoxy-4'-hydroxy-naphtho[1',2'-2,3] pyran-6-one (I) based on the physicochemical properties and spectrometric analyses (UV, IR, MS, 1HNMR and 13CNMR). The other three were 3'-carbomethoxy-4'-hydroxy-naphtho [1',2'-2,3] furan (II), dihydromollugin (III) and 3-carbomethoxy-2-(3'-hydroxy)isopentyl-1,4-naphthohydroquinone-1-O -beta-D-glucoside (IV).
Asunto(s)
Medicamentos Herbarios Chinos/química , Naftoles/aislamiento & purificación , Pironas/aislamiento & purificaciónRESUMEN
Seven anthraquinones were isolated from the ethyl alcohol extracts of the roots of Rubia Cordifolia L. By means of spectrometric data combined with physico-chemical properties, six of them were identified as 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone (I), 1-hydroxy-9,10-anthraquinone(II), 1,2,4-trihydroxy-9,10-anthrequinone(III), 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-beta-D-glucoside(IV), 1,2-dijhydroxy-9,10-anthraquinone-2-O-beta-D-xylosyl(1-->6)-beta-D -glucoside(V) and 1,3-dihydroxy-2-hydroxymethyl1-9,10-anthraquinone-3-O-beta-D- xylosyl(1-->6)-beta-D-glucoside(VI). VII is a new compound. Its structure was elucidated to be 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-beta-D-xylosyl(1-->2)-b eta-D- (6'-O-acetyl)glucoside.
Asunto(s)
Antraquinonas/aislamiento & purificación , Disacáridos/aislamiento & purificación , Medicamentos Herbarios Chinos/química , Glicósidos , Antraquinonas/química , Disacáridos/química , Estructura MolecularRESUMEN
Five monoterpenoids have been isolated from the roots of Cynanchum hancockianum (Maxim) AI. Iljinski. Their structures were determined on the basis of spectral evidence. The three new compounds are: 4-p-menthane-1,7,8-triol (III), neohancoside A (IV), neohancoside B (V), and the two knowns: 4-p-menthene-1-8, 9-diol (I), and 4-p-menthane-1,8, 9-triol (II). Compound V was purified by acetylation.
Asunto(s)
Medicamentos Herbarios Chinos/química , Mentol/análogos & derivados , Terpenos/aislamiento & purificación , Monoterpenos Ciclohexánicos , Mentol/química , Mentol/aislamiento & purificación , Estructura Molecular , Terpenos/químicaRESUMEN
Four new triterpenoids have been isolated from the petroleum ether extract of Cyananchum hancockianum (Maxim) Al. Iljinski (Asclepiadaceae). On the basis of spectral data (1HNMR, 13CNMR, 1H-1H COSY, 1H-13C COSY, longrange 1H-13C COSY, MS, X-Ray analysis) and chemical connections, they were identified as hancockinol (Ia), hancolupenol (IIa), hancolupenone (IIc), and hancolupenol octacosanate (IId). They are of new skeletons with B/C cis, C/D trans, D/E cis junctures for Ia and with A/B trans, C/D trans, D/E cis junctures for IIa, IIc and IId.
Asunto(s)
Medicamentos Herbarios Chinos/química , Triterpenos/aislamiento & purificación , Conformación Molecular , Triterpenos/químicaRESUMEN
Twelve compounds were isolated from the roots of Rubia cordifolia L.. Nine of them were established by chemical and spectroscopic methods to be alizarin (I),1-hydroxy-2-methyl-9,10-anthraquinone(II),1,3,6-trihydroxy-2-methyl- 9,10-anthra-quinone-3-O-(6'-O-acetyl)-alpha-L-rhamnosyl(1--- -2)-beta-D- glucoside(III),1,3,6-trihydroxy-2-methyl-9,10-anthraqueinone-3-O-a lpha- L-rhamnosyl(1----2)-beta-D-glucoside(IV),1,3,6-trihydrozy-2- methyl-9,10- anthraquinone-3-O-(6'-O-acetyl)-beta-D-glucoside(V),2-carbomethyoxy++ +-3-prenyl- 1,4-naphthohydroquinone di-beta-D-glucoside(VI),rubimallin(VII),beta- sitosterol(VIII) and daucosterol(IX), among them, V is a nwe compound and IX was obtained from this genus for the first time, III, VI and VII showed certain antibacterial activities.
Asunto(s)
Antraquinonas/farmacología , Medicamentos Herbarios Chinos/química , Glucósidos/farmacología , Antraquinonas/química , Antraquinonas/aislamiento & purificación , Escherichia coli/efectos de los fármacos , Glucósidos/química , Glucósidos/aislamiento & purificación , Pruebas de Sensibilidad Microbiana , Staphylococcus aureus/efectos de los fármacosRESUMEN
Three compounds were isolated from benzene and acetone extracts of the root-sprouts of Agrimonia pilosa Ledeb. On the basis of physicochemical properties, spectroscopy (UV, IR, NMR, MS, CD, GC) and chemical degradation, two known compounds were identified as palmitic acid (VIII) and daucosterol (IX), one new compound was elucidated as (2S,3S)-(-)-taxifolin-3-O-beta-D-glucopyranoside (X).
Asunto(s)
Medicamentos Herbarios Chinos/química , Glucósidos/aislamiento & purificación , Ácidos Palmíticos/aislamiento & purificación , Quercetina/análogos & derivados , Sitoesteroles/aislamiento & purificación , Quercetina/aislamiento & purificaciónRESUMEN
Four compounds were isolated from the root-sprouts of Agrimonia pilosa Ledeb. On the basis of physico-chemical properties, spectroscopy (UV, IR, NMR, MS) and chemical degradation, a new compound was elucidated as ellagic acid-4-O-beta-D-xylopyranoside (XV), and three known compounds were identified as agrimonolide (XIII), tormentic acid (XIV), and ellagic acid (XVI).
Asunto(s)
Ácido Elágico/análogos & derivados , Ácido Elágico/aislamiento & purificación , Plantas Medicinales/análisis , Benzopiranos/química , Benzopiranos/aislamiento & purificación , Ácido Elágico/química , Isocumarinas , Medicina Tradicional China , Triterpenos/química , Triterpenos/aislamiento & purificaciónRESUMEN
The structures and identification of five flavonoids from Oxytropis glabra are described. The five flavonoids are kaempferol, quercetin, kaempferol-3-beta-D-glucoside, kaempferol-7-alpha-L-rhamnoside and kaempferol-3-diglucoside. All of them were isolated from this plant for the first time.
Asunto(s)
Medicamentos Herbarios Chinos/análisis , Fabaceae , Flavonoides/aislamiento & purificación , Quempferoles , Plantas Medicinales , Quercetina/aislamiento & purificaciónRESUMEN
Thirteen compounds have been isolated from Gerbera anandria (L.) Sch Bip. Among them, three new compounds were elucidated by chemical correlations and spectral analyses. They are 3.8-dihydroxy-4-methoxy-coumarin (XIX), 3,8-dihydroxy-4-methoxy-2-oxo-2H-1-benzopyran-5-carboxylic acid (XVII), and 5,8-dihydroxy-7-(4-hydroxy-5-methyl-coumarin-3-)coumarin (XXI).
Asunto(s)
4-Hidroxicumarinas/aislamiento & purificación , Antiinfecciosos/aislamiento & purificación , Medicamentos Herbarios Chinos/análisis , Fenómenos Químicos , QuímicaRESUMEN
Trans-p-hydroxycinnamic esters VI and an isocoumarin glucoside VII were isolated from the benzene and acetone extracts of the root sprouts of Agrimonia pilosa Ledeb. On the basis of physicochemical properties, spectral data (UV, IR, NMR, MS, CI-MS-MS), GC and chemical degradation, VI was elucidated as trans-p-hybroxycinnamic esters of n-C22, n-C24-32, n-C34, alcohols, VII was elucidated as agrimonolide-6-Q-beta-D-glucopyranoside. VII and trans-p-hydroxycinnamic esters of n-C29-32 and n-C34 alcohols are new compounds.
Asunto(s)
Cumarinas/aislamiento & purificación , Medicamentos Herbarios Chinos/análisis , Glucósidos/aislamiento & purificación , Glicósidos/aislamiento & purificación , Fenómenos Químicos , Química , IsocumarinasRESUMEN
Two minor compounds isolated from the leaves of Panax ginseng C. A. Meyer were characterized as 20(R)-protopanaxadiol (I) and 3 beta, 6 alpha, 12 beta-trihydroxydammar-20 (22), 24-diene-6-O-alpha-L-rhamnosyl-(1----2)-beta-D-glucopyranoside (II) on the basis of spectral analysis and chemical evidences. I was isolated for the first time from the leaves; II was shown to be a new saponin and was named as ginsenoside-Rg4.
Asunto(s)
Ginsenósidos , Panax/análisis , Plantas Medicinales , Sapogeninas , Saponinas/aislamiento & purificación , Triterpenos/aislamiento & purificación , Fenómenos Químicos , Química , Saponinas/análisisRESUMEN
Five compounds were isolated from the petroleum ether extract of the root-sprouts of Agrimonia pilosa Ledob. A new compound, (R)-(-)-agrimol B (III), was elucidated by means of physical and chemical properties, spectroscopy (MS, IR, PMR, UV) and total synthesis. Four known compounds were identified as agrimophol (I), n-nonacosane (II), beta-sitosterol (IV) and pseudo-aspidin (V), the last one being previously known only as a synthetic entity. (S)-(+)-Agrimol B also was synthesized.