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1.
Arch Dermatol Res ; 299(10): 499-505, 2007 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-17960402

RESUMEN

The appearance of hair plays an important role in people's overall physical appearance and self-perception. Silicon (Si) has been suggested to have a role in the formation of connective tissue and is present at 1-10 ppm in hair. Choline-stabilized orthosilicic acid ("ch-OSA") is a bioavailable form of silicon which was found to improve skin microrelief and skin mechanical properties in women with photoaged skin. The effect of ch-OSA on hair was investigated in a randomized, double blind, placebo-controlled study. Forty-eight women with fine hair were given 10 mg Si/day in the form of ch-OSA beadlets (n = 24) or a placebo (n = 24), orally for 9 months. Hair morphology and tensile properties were evaluated before and after treatment. Urinary silicon concentration increased significantly in the ch-OSA supplemented group but not in the placebo group. The elastic gradient decreased in both groups but the change was significantly smaller in the ch-OSA group (-4.52%) compared to placebo group (-11.9%). Break load changed significantly in the placebo group (-10.8%) but not in the ch-OSA supplemented group (-2.20%). Break stress and elastic modulus decreased in both groups but the change was smaller in the ch-OSA group. The cross sectional area increased significantly after 9 months compared to baseline in ch-OSA supplemented subjects but not in the placebo group. The change in urinary silicon excretion was significantly correlated with the change in cross sectional area. Oral intake of ch-OSA had a positive effect on tensile strength including elasticity and break load and resulted in thicker hair.


Asunto(s)
Suplementos Dietéticos , Cabello/efectos de los fármacos , Ácido Silícico/farmacología , Adolescente , Adulto , Colina , Método Doble Ciego , Femenino , Cabello/anatomía & histología , Cabello/fisiología , Humanos , Persona de Mediana Edad , Ácido Silícico/química , Ácido Silícico/farmacocinética , Resistencia a la Tracción/efectos de los fármacos
2.
Calcif Tissue Int ; 78(4): 227-32, 2006 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-16604283

RESUMEN

Silicon (Si) deficiency in animals results in bone defects. Choline-stabilized orthosilicic acid (ch-OSA) was found to have a high bioavailability compared to other Si supplements. The effect of ch-OSA supplementation was investigated on bone loss in aged ovariectomized (OVX) rats. Female Wistar rats (n = 58, age 9 months) were randomized in three groups. One group was sham-operated (sham, n = 21), and bilateral OVX was performed in the other two groups. OVX rats were supplemented orally with ch-OSA over 30 weeks (OVX1, n = 20; 1 mg Si/kg body weight daily) or used as controls (OVX0, n = 17). The serum Si concentration and the 24-hour urinary Si excretion of supplemented OVX rats was significantly higher compared to sham and OVX controls. Supplementation with ch-OSA significantly but partially reversed the decrease in Ca excretion, which was observed after OVX. The increase in bone turnover in OVX rats tended to be reduced by ch-OSA supplementation. ch-OSA supplementation increased significantly the femoral bone mineral content (BMC) in the distal region and total femoral BMC in OVX rats, whereas lumbar BMC was marginally increased. Femoral BMD was significantly increased at two sites in the distal region in OVX rats supplemented with ch-OSA compared to OVX controls. Total lumbar bone mineral density was marginally increased by ch-OSA supplementation. In conclusion, ch-OSA supplementation partially prevents femoral bone loss in the aged OVX rat model.


Asunto(s)
Envejecimiento , Suplementos Dietéticos , Fémur/efectos de los fármacos , Osteoporosis/dietoterapia , Osteoporosis/prevención & control , Ácido Silícico/uso terapéutico , Absorciometría de Fotón , Animales , Densidad Ósea/efectos de los fármacos , Calcio/orina , Colina , Femenino , Fémur/fisiología , Vértebras Lumbares/efectos de los fármacos , Vértebras Lumbares/fisiología , Ovariectomía , Ratas , Ratas Wistar , Ácido Silícico/análisis , Ácido Silícico/química
3.
Arch Dermatol Res ; 297(4): 147-53, 2005 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-16205932

RESUMEN

Chronic exposure of the skin to sunlight causes damage to the underlying connective tissue with a loss of elasticity and firmness. Silicon (Si) was suggested to have an important function in the formation and maintenance of connective tissue. Choline-stabilized orthosilicic acid ("ch-OSA") is a bioavailable form of silicon which was found to increase the hydroxyproline concentration in the dermis of animals. The effect of ch-OSA on skin, nails and hair was investigated in a randomized, double blind, placebo-controlled study. Fifty women with photodamaged facial skin were administered orally during 20 weeks, 10 mg Si/day in the form of ch-OSA pellets (n=25) or a placebo (n=25). Noninvasive methods were used to evaluate skin microrelief (forearm), hydration (forearm) and mechanical anisotropy (forehead). Volunteers evaluated on a virtual analog scale (VAS, "none=0, severe=3") brittleness of hair and nails. The serum Si concentration was significantly higher after a 20-week supplementation in subjects with ch-OSA compared to the placebo group. Skin roughness parameters increased in the placebo group (Rt:+8%; Rm: +11%; Rz: +6%) but decreased in the ch-OSA group (Rt: -16%; Rm: -19%; Rz: -8%). The change in roughness from baseline was significantly different between ch-OSA and placebo groups for Rt and Rm. The difference in longitudinal and lateral shear propagation time increased after 20 weeks in the placebo group but decreased in the ch-OSA group suggesting improvement in isotropy of the skin. VAS scores for nail and hair brittleness were significantly lower after 20 weeks in the ch-OSA group compared to baseline scores. Oral intake of ch-OSA during the 20 weeks results in a significant positive effect on skin surface and skin mechanical properties, and on brittleness of hair and nails.


Asunto(s)
Colina , Cabello/efectos de los fármacos , Uñas/efectos de los fármacos , Ácido Silícico/administración & dosificación , Piel/efectos de los fármacos , Piel/efectos de la radiación , Rayos Ultravioleta/efectos adversos , Administración Oral , Adulto , Anciano , Fenómenos Biomecánicos , Método Doble Ciego , Cara , Femenino , Cabello/patología , Cabello/fisiopatología , Humanos , Hidroxiprolina/metabolismo , Persona de Mediana Edad , Uñas/patología , Uñas/fisiopatología , Ácido Silícico/farmacología , Ácido Silícico/uso terapéutico , Silicio/sangre , Piel/metabolismo , Piel/patología , Factores de Tiempo
4.
Planta Med ; 67(6): 515-9, 2001 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-11509970

RESUMEN

Thirty-five flavonoids of seven different types, namely isoflavonoids, chalcones, dihydroflavonols, flavanols, flavanones, flavones, and flavonols were investigated for their ability to inhibit ascorbate-induced microsomal lipid peroxidation and their cytotoxicity. For each activity a structure-activity relationship was established. Subsequently, an antioxidant selectivity index, i. e., the maximal non-toxic dose divided by the IC(50) value for lipid peroxidation, was introduced. Kaempferol showed the highest antioxidant selectivity index of all flavonoids tested.


Asunto(s)
Antioxidantes/farmacología , Flavonoides/toxicidad , Peroxidación de Lípido/efectos de los fármacos , Microsomas Hepáticos/efectos de los fármacos , Animales , Células Cultivadas , Fibroblastos/efectos de los fármacos , Flavonoides/antagonistas & inhibidores , Flavonoides/química , Flavonoides/farmacología , Humanos , Concentración 50 Inhibidora , Masculino , Ratas , Ratas Wistar , Piel/efectos de los fármacos , Relación Estructura-Actividad
5.
J Ethnopharmacol ; 65(1): 71-7, 1999 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-10350370

RESUMEN

Aqueous EtOH (80%) extracts of seven plants used by Rwandan traditional healers to treat infections, were screened for antibacterial, antifungal, and antiviral activities. Only two of the selected plants showed a true antiviral activity against herpes simplex virus type 1, while all of them exhibited virucidal properties against several enveloped viruses including herpes simplex, measles, Semliki forest, and vesicular stomatitis viruses. Four plants were diversely active against gram-positive bacteria, two of these showing bactericidal effect against the acid-fast Mycobacterium fortuitum. None of the selected plants was active against gram-negative bacteria or the yeast Candida albicans. From a bioassay-guided fractionation procedure using herpes simplex virus type I as the target model, a virucidal mixture, the maesasaponin mixture A, was isolated from the MeOH extract of Maesa lanceolata. The maesasaponin mixture A exhibited a virucidal activity against herpes simplex types 1 and 2, and vesicular stomatitis viruses.


Asunto(s)
Antiinfecciosos/uso terapéutico , Antivirales/uso terapéutico , Extractos Vegetales/uso terapéutico , Plantas Medicinales/química , Antibacterianos , Antifúngicos/uso terapéutico , Bacterias/efectos de los fármacos , Evaluación Preclínica de Medicamentos/métodos , Rwanda
6.
J Nat Prod ; 61(5): 585-90, 1998 May.
Artículo en Inglés | MEDLINE | ID: mdl-9599254

RESUMEN

From a bioassay-guided fractionation procedure using Herpes simplex virus type 1 as the target model, a virucidal saponin mixture (maesasaponin mixture B) was isolated from the MeOH extract of leaves of Maesa lanceolata. The maesasaponin mixture B consisted of six homologous oleanane-type triterpenoid saponins 1-6, identified by 1H, 13C, and 2D NMR spectroscopy and mass spectrometry. The maesasaponin mixture B (1-6) showed several biological activities expected for saponins. It exhibited a moderate virucidal activity against enveloped viruses. The maesasaponin mixture B (1-6) was tested for further properties. The saponin mixture was found to be highly hemolytic and molluscicidal: it hemolyzed 50% of human erythrocytes (1% suspension) at a concentration estimated at 1.6 microg/mL and exerted against Biomphalaria glabrata snails a severe toxic effect with LD95 and LD50 values of 4.1 and 2.3 ppm, respectively. In addition, the maesasaponin mixture B (1-6) showed moderate fungistatic and antimutagenic properties. The evaluation of these diverse activities is described.


Asunto(s)
Moluscos/efectos de los fármacos , Plantas Medicinales/química , Saponinas/farmacología , Árboles/química , Triterpenos/farmacología , Animales , Antifúngicos/química , Antifúngicos/aislamiento & purificación , Antifúngicos/farmacología , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/aislamiento & purificación , Antineoplásicos Fitogénicos/farmacología , Antivirales/química , Antivirales/aislamiento & purificación , Antivirales/farmacología , Conformación de Carbohidratos , Secuencia de Carbohidratos , Hemólisis/efectos de los fármacos , Humanos , Datos de Secuencia Molecular , Hojas de la Planta/química , Saponinas/química , Saponinas/aislamiento & purificación , Triterpenos/química , Triterpenos/aislamiento & purificación
7.
Biol Trace Elem Res ; 56(2): 153-65, 1997 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-9164661

RESUMEN

The bioavailability of silicon in stabilized orthosilicic acid was investigated in a double blind, placebo controlled supplementation study of calves maintained on a normal diet. The total dietary Si intake was increased by 4.9% in the form of stabilized orthosilicic acid. After 23 wk of Si supplementation, the serum Si concentration increased (p = 0.0001, n = 29) by 70% compared to control animals in spite of the low Si dose administered and the Si adequate diet. The individually administered Si dose was significantly associated with the serum Si concentration (r = 0.44, p = 0.016, n = 29). The collagen concentration in dermis was significantly higher (p = 0.019, n = 4) in the Si group and a positive correlation (r = 0.72, p = 0.018, n = 9) was found between the Si concentration in serum and the collagen concentration in cartilage. The calcium (Ca) and phosphorus (P) concentrations in serum were marginally higher for animals supplemented with Si compared to control animals. In serum, a significant linear relationship was found between the Si and the Ca concentration (r = 0.31, p = 0.019, n = 59), whereas the magnesium concentration correlated marginally with the Si concentration (r = 0.25, p = 0.068, n = 59). In summary, increasing the total dietary Si intake by 4.9% in the form of stabilized orthosilicic acid resulted in a 70% higher Si concentration in serum indicating a high bioavailability of Si in this supplement. The positive correlation between the serum Si concentration and the collagen concentration in cartilage and the serum Ca concentration, respectively, suggest the involvement of Si both in the formation of extracellular matrix components and in Ca metabolism.


Asunto(s)
Calcio/sangre , Cartílago/metabolismo , Colágeno/metabolismo , Alimentos Fortificados , Magnesio/sangre , Fósforo/sangre , Ácido Silícico/farmacología , Silicio/sangre , Piel/metabolismo , Animales , Estatura , Peso Corporal , Bovinos , Colágeno/efectos de los fármacos , Método Doble Ciego , Estabilidad de Medicamentos , Crecimiento/efectos de los fármacos , Hidroxiprolina/química , Leche , Ácido Silícico/administración & dosificación , Ácido Silícico/metabolismo , Silicio/deficiencia
8.
Planta Med ; 62(3): 222-6, 1996 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-8693033

RESUMEN

The antimutagenicity of the Citrus flavonoids naringin, hesperidin, nobiletin, and tangeretin against the mutagens benzo[a]pyrene, 2-aminofluorene, quercetin, and nitroquinoline N-oxide was investigated in the Salmonella/microsome assay. Naringin and hesperidin showed a weak antimutagenic activity against benzo[a]pyrene. Tangeretin was antimutagenic against all indirectly-acting mutagens tested, but in general a large molar excess was necessary. Liquid preincubation increased the antimutagenicity of tangeretin against 2-aminofluorene. Nobiletin acted as an antimutagen against benzo[a]pyrene, but it enhanced the mutagenicity of 2-aminofluorene. However, in a liquid preincubation assay nobiletin also exhibited antimutagenicity against 2-aminofluorene. Both tangeretin and nobiletin inhibited the mutagenicity of quercetin. Quercetin itself acted as an antimutagen against 2-aminofluorene in a Salmonella strain (TA1538) where its mutagenicity was not expressed. Quercetin should not merely be regarded as a genotoxic risk factor in the human diet, since its mutagenicity may be inhibited by accompanying compounds including other flavonoids, and since quercetin itself also exhibits an antimutagenic action. Because of the antimutagenic properties the Citrus flavonoids tested, especially tangeretin and nobiletin, might play a role in the chemoprevention of cancer.


Asunto(s)
Antimutagênicos/farmacología , Antioxidantes/farmacología , Citrus , Flavanonas , Flavonas , Flavonoides/farmacología , Mutágenos/farmacología , Salmonella typhimurium/efectos de los fármacos , Anticarcinógenos , Antimutagênicos/aislamiento & purificación , Antioxidantes/aislamiento & purificación , Benzo(a)pireno/farmacología , Dieta , Flavonoides/aislamiento & purificación , Hesperidina/farmacología , Humanos , Pruebas de Mutagenicidad
9.
Experientia ; 51(12): 1208-15, 1995 Dec 18.
Artículo en Inglés | MEDLINE | ID: mdl-8536808

RESUMEN

Phenylketonuric (PKU) subjects have a limited supply of selenium (Se) in their phenylalanine-restricted diet. A Se repletion (1 microgram Se/kg/day)/depletion study was conducted in PKU children to determine the effect of Se on thyroid function parameters. The initial plasma Se concentration (mean +/- SD: 0.26 +/- 0.12 mumol/L, p < 0.00003, n = 10) and glutathione peroxidase (GSH-Px) activity (140 +/- 58 U/L, p < 0.00003, n = 10) were significantly lower compared to age-matched controls. After 14 weeks of supplementation, the plasma Se concentration (mean +/- SD: 0.74 +/- 0.20 mumol/L) normalized (normal range: 0.57-1.15 mumol/L, mean +/- SD: 0.76 +/- 0.13 mumol/L, n = 32) and remained stable thereafter during repletion. Plasma GSH-Px activity reached normal values after 18 weeks of supplementation (312 +/- 57 U/L; normal range: 238-492 U/L, mean +/- SD: 345 +/- 54 U/L, n = 32) and increased significantly for up to eight weeks thereafter (332 +/- 52 U/L). Individual and mean thyroid parameters were initially normal in all cases. The mean concentrations of plasma thyroxine (T4: p < 0.025), free T4 (FT4: p < 0.01) and reverse triiodothyronine (rT3: p < 0.005) decreased to 75% of their initial value within three weeks of Se supplementation and remained stable thereafter, within a normal physiological range during selenium supplementation. They increased back to their initial values three weeks (T4: p < 0.05, FT4: p < 0.05) and six weeks (rT3: p < 0.025) respectively, after the end of the supplementation. In conclusion, Se supplementation modifies thyroid function parameters in Se-deficient PKU subjects most likely by an increase in activity of type I 5'-deiodinase (5'-DIase I).


Asunto(s)
Fenilcetonurias/fisiopatología , Selenio/administración & dosificación , Glándula Tiroides/fisiopatología , Adolescente , Niño , Femenino , Glutatión Peroxidasa/sangre , Humanos , Yoduro Peroxidasa/sangre , Masculino , Selenio/sangre , Hormonas Tiroideas/sangre
10.
Biol Trace Elem Res ; 47(1-3): 349-53, 1995.
Artículo en Inglés | MEDLINE | ID: mdl-7779569

RESUMEN

Type I 5'-deiodinase was recently characterized as a selenocysteine-containing enzyme in humans and other mammals. Up to now, the effect of selenium (Se) supplementation on thyroid hormone metabolism in humans has only been reported in the very peculiar nutritional environment of Central Africa, where combined severe iodine and Se deficiency occurs. In this study, a group of phenylketonuria subjects with a low selenium status, but a normal iodine intake were supplemented with selenium to investigate changes in their thyroid hormone metabolism. After 3 wk of selenium supplementation (1 microgram/kg/d), both the concentrations of the prohormone thyroxine (T4) and the metabolic inactive reverse triiodothyronine (rT3) decreased significantly. Clinically, the phenylketonuria subjects remained euthyroid before and after selenium supplementation. The individual changes of plasma Se and glutathione peroxidase activity were closely associated with individual changes of plasma T4 and rT3.


Asunto(s)
Glutatión Peroxidasa/sangre , Fenilcetonurias/sangre , Selenio/farmacología , Tiroxina/sangre , Triyodotironina Inversa/sangre , Triyodotironina/sangre , Adolescente , Animales , Niño , Humanos , Mamíferos , Fenilalanina , Fenilcetonurias/dietoterapia , Fenilcetonurias/fisiopatología , Selenio/administración & dosificación , Tirotropina/sangre , Proteínas de Unión a Tiroxina/análisis , Factores de Tiempo
11.
Biol Trace Elem Res ; 47(1-3): 379-83, 1995.
Artículo en Inglés | MEDLINE | ID: mdl-7779573

RESUMEN

Lactic acid bacteria are nonpathogenic bacteria commonly used in food processing. An evaluation was made of the capacity to concentrate selenium in species of Lactobacillus. A selenium concentration of 1 microgram/mL in the culture medium yielded in a bacterial content of 400 micrograms/g dry biomass. Dialysis and TCA precipitation experiments of a native intracellular extract proved that at least 80% of the total selenium is associated with organic molecules. Seleno-cysteine was identified as the only seleno-amino acid present in the intracellular selenoproteins. This study shows that species of the lactic acid bacteria are able to concentrate selenium intracellular as seleno-cysteine, which could be applied in supplementation studies.


Asunto(s)
Lactobacillus/metabolismo , Selenio/metabolismo , Autorradiografía , Proteínas Bacterianas/aislamiento & purificación , Proteínas Bacterianas/metabolismo , Técnicas Bacteriológicas , Biomasa , Medios de Cultivo , Electroforesis en Gel de Poliacrilamida , Liofilización , Lactobacillus/química , Lactobacillus/crecimiento & desarrollo , Lacticaseibacillus casei/química , Lacticaseibacillus casei/crecimiento & desarrollo , Lacticaseibacillus casei/metabolismo , Selenio/análisis , Radioisótopos de Selenio , Especificidad de la Especie
12.
Neuropediatrics ; 25(4): 217-23, 1994 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-7824095

RESUMEN

Two children with severe neurodevelopmental retardation and elevated liver function tests developed intractable seizures during the first year of life. Detectable neurometabolic conditions have been ruled out. At the time of seizures evidence for systemic selenium deficiency could be documented. The youngest patient, who manifested intractable fits from the fourth day of life, died at the age of ten months. Neuropathologic examination was consistent with Progressive Neuronal Degeneration of Childhood (PNDC) with liver disease or formerly known as Alpers disease. In the oldest child, whose diet was normally balanced, fits started from the age of 11 months and features of long-standing selenium deficiency became apparent from the age of 1 1/2 years and consisted of liver function disturbances, depigmented hair and osteoarthropathy. Oral substitution with selenium supplements in both children (3-5 micrograms/kg body weight) resulted in reduction of seizures and improvement of the EEG recordings after two weeks while liver function became normal. Two of the seleno-dependent enzymes Glutathione Peroxidase (GPX) and Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX) are speculated to play a key-role in the defence of neuronal cells against oxygen radical formation and peroxidative processes. Our findings support the hypothesis that the presence of selenium depletion in the brain amongst patients with epilepsy constitutes an important triggering factor for the origin of intractable seizures and subsequent neuronal damage.


Asunto(s)
Peroxidación de Lípido/fisiología , Selenio/deficiencia , Espasmos Infantiles/fisiopatología , Atrofia , Encéfalo/patología , Esclerosis Cerebral Difusa de Schilder/patología , Esclerosis Cerebral Difusa de Schilder/fisiopatología , Electroencefalografía/efectos de los fármacos , Femenino , Radicales Libres , Glutatión Peroxidasa/fisiología , Humanos , Lactante , Recién Nacido , Masculino , Degeneración Nerviosa/fisiología , Examen Neurológico , Fosfolípido Hidroperóxido Glutatión Peroxidasa , Especies Reactivas de Oxígeno/metabolismo , Selenio/administración & dosificación , Selenio/líquido cefalorraquídeo , Espasmos Infantiles/patología
13.
J Nat Prod ; 56(6): 899-906, 1993 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-8350090

RESUMEN

Dragon's blood is a red viscous latex extracted from the cortex of various Croton spp. (Euphorbiaceae), most commonly Croton lechleri, Croton draconoides (or Croton palanostigma), and Croton erythrochilus. It is used in South American popular medicine for several purposes, including wound healing. Bioassay-guided fractionation of dragon's blood, using an in vitro test system for the stimulation of human umbilical vein endothelial cells, has resulted in the isolation of a dihydrobenzofuran lignan, 3',4-O-dimethylcedrusin or 4-O-methyldihydrodehydrodiconiferyl alcohol [2-(3',4'-dimethoxyphenyl)-3-hydroxymethyl-2,3-dihydro-7-methoxybenzo furan-5- propan-1-ol] [1] as the biologically active principle. A related compound, 4-O-methylcedrusin [2-(3',4'-dimethoxyphenyl)-3-hydroxymethyl-2,3-dihydro-7-hydroxybenzo furan-5- propan-1-ol] [2], and the alkaloid taspine [3], also isolated from dragon's blood, were not active in the same assay. A cell proliferation assay, measuring the incorporation of tritiated thymidine in endothelial cells, showed that compound 1 did not stimulate cell proliferation, but rather inhibited thymidine incorporation, while protecting cells against degradation in a starvation medium.


Asunto(s)
Antineoplásicos Fitogénicos/química , Plantas Medicinales/química , Alcaloides/química , Alcaloides/farmacología , Anisoles/química , Anisoles/farmacología , Antineoplásicos Fitogénicos/farmacología , Benzofuranos/química , Benzofuranos/farmacología , División Celular/efectos de los fármacos , Supervivencia Celular/efectos de los fármacos , Endotelio Vascular/efectos de los fármacos , Femenino , Humanos , Espectroscopía de Resonancia Magnética , Espectrometría de Masas , Conformación Molecular , Embarazo , América del Sur , Timidina/metabolismo , Venas Umbilicales/citología , Venas Umbilicales/efectos de los fármacos
14.
Mutat Res ; 281(2): 143-7, 1992 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-1370983

RESUMEN

The mutagenicity of a series of pyrrolizidine alkaloids, and of extracts from several Italian Senecio species containing pyrrolizidine alkaloids, including S. inaequidens, S. fuchsii and S. cacaliaster, were tested using the Salmonella typhimurium/mammalian microsome system. Retrorsine, senecivernine, seneciphylline and the Senecio extracts showed a weakly mutagenic activity.


Asunto(s)
Mutágenos/toxicidad , Extractos Vegetales/toxicidad , Plantas Tóxicas , Alcaloides de Pirrolicidina/toxicidad , Senecio/química , Animales , Relación Dosis-Respuesta a Droga , Técnicas In Vitro , Microsomas Hepáticos/metabolismo , Pruebas de Mutagenicidad , Ratas , Ratas Endogámicas , Salmonella typhimurium/efectos de los fármacos
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