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1.
Nutrition ; 34: 47-54, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-28063511

RESUMEN

Diabetic cardiomyopathy (DCM) is described as impaired cardiac diastolic and systolic functions. Diabetes mellitus (DM), a related cardiovascular disease, has become one of the major causes of death in DM patients. Mortality in these diseases is 2 to 3 times higher than in non-DM patients with cardiovascular disease. The progression of DCM and the cellular and molecular perturbations associated with the pathogenesis are complex and multifactorial. Although considerable progress has been achieved, the molecular etiologies of DCM remain poorly understood. There is an expanding need for natural antidiabetic medicines that do not cause the side effects of modern drugs. Curcumin, a pleiotropic molecule, from Curcuma longa, is known to possess numerous impacts such as scavenging free radical, antioxidant, antitumor, and antiinflammatory activities. The reports from preclinical and clinical findings revealed that curcumin can reverse insulin resistance, hyperglycemia, obesity, and obesity-related metabolic diseases. The current review provides an updated overview of the possible molecular mechanism of DCM and multitarget approach of curcumin in alleviating DCM and diabetic complication. Additionally, we mentioned the approaches that are currently being implemented to improve the bioavailability of this promising natural product in diabetes therapeutics.


Asunto(s)
Curcumina/farmacocinética , Cardiomiopatías Diabéticas/tratamiento farmacológico , Hipoglucemiantes/farmacocinética , Animales , Antiinflamatorios/administración & dosificación , Antiinflamatorios/farmacocinética , Antioxidantes/administración & dosificación , Antioxidantes/farmacocinética , Curcuma/química , Curcumina/administración & dosificación , Curcumina/química , Modelos Animales de Enfermedad , Corazón/efectos de los fármacos , Corazón/fisiología , Humanos , Hipoglucemiantes/administración & dosificación , Estrés Oxidativo/efectos de los fármacos , Extractos Vegetales/administración & dosificación , Extractos Vegetales/farmacocinética
3.
Int Immunopharmacol ; 29(2): 957-963, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26548346

RESUMEN

Jumihaidokuto, a Japanese kampo medicine, is prescribed in Japan for its anti-inflammatory activity. Here we have examined its beneficial effects against acute colitis induced by dextran sulfate sodium (DSS) in mice. We have used C57BL/6 female mice, divided into two groups and received 3% DSS in drinking water during the experimental period (8days). Treatment group mice received 1g/kg/day dose of Jumihaidokuto orally whereas DSS control group received equal volume of distilled water. Normal control group mice received plain drinking water. Jumihaidokuto treatment attenuated the colitis symptoms along with suppression of various inflammatory marker proteins such as IL-1ß, IL-2Rα, IL-4, CTGF and RAGE. It has also down-regulated the oxidative stress and apoptotic signaling in the colons of mice with colitis. The present study has confirmed the beneficial effects of Jumihaidokuto on DSS induced acute colitis in mice and suggests that it can be a potential agent for the treatment of colitis.


Asunto(s)
Apoptosis/efectos de los fármacos , Colitis/inducido químicamente , Colitis/tratamiento farmacológico , Extractos Vegetales/uso terapéutico , Enfermedad Aguda , Animales , Biomarcadores/análisis , Biomarcadores/metabolismo , Peso Corporal/efectos de los fármacos , Degranulación de la Célula/efectos de los fármacos , Citocinas/biosíntesis , Sulfato de Dextran , Femenino , Inflamación/metabolismo , Mastocitos/efectos de los fármacos , Mastocitos/inmunología , Ratones , Ratones Endogámicos C57BL , Estrés Oxidativo/efectos de los fármacos
4.
Int Immunopharmacol ; 29(2): 869-875, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26344429

RESUMEN

Toki-shakuyaku-san (TOKI) is a Japanese kampo medicine, which consists of a mixture of herbal medicines and considered to be a promising remedial agent due to its immunomodulatory and anti-inflammatory effects. We examined the beneficial effects of TOKI in inflammatory bowel disease associated with the inflammation of the intestinal barrier. A study was designed, using C57BL/6 female mice and were administered with 3% DSS in drinking water for 8days with or without 1g/kg/day TOKI orally for the last 3days and a normal group supplied with plain drinking water for 8days. TOKI treatment attenuated the clinical symptoms of acute murine colitis and also alleviated the inflammatory mechanism by reducing the inflammatory mediators, such as IL-1ß, IL-2, TGF-ß, RAGE and TLR2. It has also decreased the levels of CHOP, caspase12, cleaved caspase3 and cleaved caspase7 and thereby down-regulated the endoplasmic reticulum stress and apoptotic signaling induced by DSS. Moreover, the expression levels of cyclin D1 and c-kit have also confirmed the beneficial role of TOKI in colitis. All these data suggested that TOKI can be a promising agent for the treatment of colitis since it alleviates the disease progression and severity.


Asunto(s)
Antiinflamatorios no Esteroideos/uso terapéutico , Colitis/prevención & control , Medicamentos Herbarios Chinos/uso terapéutico , Medicina Kampo , Animales , Apoptosis/efectos de los fármacos , Colitis/inducido químicamente , Colon/patología , Citocinas/biosíntesis , Sulfato de Dextran , Estrés del Retículo Endoplásmico/efectos de los fármacos , Femenino , Mediadores de Inflamación , Ratones , Ratones Endogámicos C57BL , Pérdida de Peso/efectos de los fármacos
5.
Cytokine ; 74(2): 305-12, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25873126

RESUMEN

The renin angiotensin system (RAS) is essential for the regulation of cardiovascular and renal functions to maintain the fluid and electrolyte homeostasis. Recent studies have demonstrated a locally expressed RAS in various tissues of mammals, which is having pathophysiological roles in those organ system. Interestingly, local RAS has important role during the inflammatory bowel disease pathogenesis. Further to delineate its role and also to identify the potential effects of telmisartan, an angiotensin receptor blocker, we have used a mouse model of acute colitis induced by dextran sulphate sodium. We have used 0.01 and 5mg/kg body weight doses of telmisartan and administered as enema to facilitate the on-site action and to reduce the systemic adverse effects. Telmisartan high dose treatment significantly reduced the disease activity index score when compared with the colitis control mice. In addition, oxidative stress and endoplasmic reticulum stress markers expression were also significantly reduced when compared with the colitis control mice. Subsequent experiments were carried out to investigate some of the mechanisms underlying its anti-inflammatory effects and identified that the mRNA levels of pro-inflammatory cytokines such as tumour necrosis factor α, interleukin 1ß, interleukin 6 and monocyte chemoattractant protein 1 as well as cellular DNA damage were significantly suppressed when compared with the colitis control mice. Similarly the apoptosis marker proteins such as cleaved caspase 3 and 7 levels were down-regulated and anti-apoptotic protein Bcl2 level was significantly upregulated by telmisartan treatment. These results indicate that blockade of RAS by telmisartan can be an effective therapeutic option against acute colitis.


Asunto(s)
Bencimidazoles/farmacología , Benzoatos/farmacología , Colitis , Citocinas/inmunología , Sulfato de Dextran/toxicidad , Enfermedad Aguda , Animales , Caspasa 3/inmunología , Caspasa 7/inmunología , Colitis/inducido químicamente , Colitis/tratamiento farmacológico , Colitis/inmunología , Modelos Animales de Enfermedad , Femenino , Ratones , Proteínas Proto-Oncogénicas c-bcl-2/inmunología , Telmisartán
6.
Free Radic Res ; 46(1): 50-60, 2012 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-22059853

RESUMEN

This study aimed to investigate the potential beneficial effect of an antioxidant lignan, Schisandrin B (Sch B), against cisplatin (cDDP) induced oxidative stress mediated geno- and neuro-toxicities. A dose of 10 mg/kg cDDP induced considerable genotoxicity in mice, and Sch B treatment attenuated the cDDP-induced DNA damage as assessed by the comet assay in the brain. The frequency of micro-nucleated erythrocyte production in bone marrow was also significantly reduced by Sch B treatment in cDDP-treated mice. In neurobehavioral studies, Sch B significantly prevented the memory deficits induced by cDDP, and had an anxiolytic effect in the elevated plus maze task. Sch B treatment significantly attenuated lipid peroxidation, acetylcholinesterase activity and nitrite levels induced by cDDP. Furthermore, Sch B effectively inhibited NF-κB and p53 activation, and cleaved caspase-3 expression in cDDP-treated mice. Hence, Sch B with potent antioxidant and neuro-protective property with no mutagenic activity would be beneficial complementary food factor against cDDP induced oxidative stress.


Asunto(s)
Antineoplásicos/toxicidad , Cisplatino/toxicidad , Lignanos/farmacología , FN-kappa B/metabolismo , Estrés Oxidativo/efectos de los fármacos , Compuestos Policíclicos/farmacología , Acetilcolinesterasa/metabolismo , Animales , Antioxidantes/farmacología , Conducta Animal/efectos de los fármacos , Encéfalo/efectos de los fármacos , Encéfalo/enzimología , Caspasa 3/metabolismo , Ciclooctanos/farmacología , Daño del ADN , Interacciones Farmacológicas , Masculino , Ratones , Ratones Endogámicos BALB C , Destreza Motora/efectos de los fármacos , Pruebas de Mutagenicidad , FN-kappa B/biosíntesis , Proteína p53 Supresora de Tumor/biosíntesis
7.
Cardiovasc Hematol Agents Med Chem ; 9(4): 225-30, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21902660

RESUMEN

Diabetes has emerged as a major threat to worldwide health. The increasing incidence of diabetes in young individuals is particularly worrisome given that the disease is likely to evolve over a period of years. In 1972, the existence of a diabetic cardiomyopathy was proposed based on the experience with four adult diabetic patients who suffered from congestive heart failure in the absence of discernible coronary artery disease, valvular or congenital heart disease, hypertension, or alcoholism. The exact mechanisms underlying the disease are unknown; however, there is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Hyperglycemiainduced oxidative stress is a major risk factor for the development of micro-vascular pathogenesis in the diabetic myocardium, which results in myocardial cell death, hypertrophy, fibrosis, abnormalities of calcium homeostasis and endothelial dysfunction. In this review, we provide the emergence of experimental evidence supporting antioxidant supplementation as a cardioprotective intervention in the setting of diabetic cardiomyopathy.


Asunto(s)
Antioxidantes/uso terapéutico , Cardiotónicos/uso terapéutico , Cardiomiopatías Diabéticas/tratamiento farmacológico , Estrés Oxidativo/efectos de los fármacos , Animales , Antioxidantes/farmacología , Cardiotónicos/farmacología , Cardiomiopatías Diabéticas/metabolismo , Cardiomiopatías Diabéticas/patología , Corazón/efectos de los fármacos , Humanos , Miocardio/metabolismo , Miocardio/patología
8.
J Med Food ; 14(6): 601-9, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21554136

RESUMEN

The aim of this study was to examine the effect of Shengmai-san (SMS) on learning and memory impairment induced by scopolamine (1 mg/kg, i.p.) in mice. The passive avoidance task (PAT) and Morris water maze (MWM) test served as the behavioral models for testing memory. To elucidate the mechanism of its cognitive-enhancing activity, the effects of SMS (2, 4, or 8 g/kg) on activities of acetylcholinesterase (AChE) and antioxidant enzymes and levels of acetylcholine (ACh) and nitrite were evaluated in brain homogenate. Tacrine (THA) (10 mg/kg, p.o.) was used as a reference drug. SMS (4 or 8 g/kg) significantly prevented scopolamine-induced impairments as measured by the PAT and MWM (probe trial session). SMS (4 or 8 g/kg) also significantly reduced the oxidative-nitrative stress, as evidenced by decreased malondialdehyde and nitrite levels and by its prevention of decreases in glutathione and superoxide dismutase levels. The activity of AChE was decreased in scopolamine-treated mice but was inhibited significantly by SMS treatment (4 or 8 g/kg) in both salt- and detergent-soluble fractions of brain homogenates. Further SMS treatment (4 or 8 g/kg) significantly increased the ACh levels in the brain homogenate to a level similar to that observed in THA treatment. Thus, the significant cognitive enhancement observed after 7 days of administration of SMS is closely related to the strong antioxidant properties of SMS in addition to its inhibition of brain AChE activity. These findings stress the critical impact of SMS on higher brain functions such as learning and memory.


Asunto(s)
Enfermedad de Alzheimer/psicología , Encéfalo/metabolismo , Cognición/efectos de los fármacos , Medicamentos Herbarios Chinos/administración & dosificación , Nootrópicos/administración & dosificación , Estrés Oxidativo/efectos de los fármacos , Acetilcolinesterasa/metabolismo , Enfermedad de Alzheimer/tratamiento farmacológico , Enfermedad de Alzheimer/metabolismo , Animales , Encéfalo/efectos de los fármacos , Encéfalo/enzimología , Modelos Animales de Enfermedad , Humanos , Masculino , Malondialdehído/metabolismo , Aprendizaje por Laberinto/efectos de los fármacos , Ratones
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